Abstract: A method of operating a drive system for a load is disclosed. The drive system may have an electric motor/generator and a gas turbine engine. The engine may have a combustor, and main and pilot flow paths via which fuel is supplied to the combustor. The engine may be operable in low and standard emissions modes. A proportion of the fuel that is supplied to the combustor via the pilot flow path may be greater in the standard emissions mode than in the low emissions mode. The method may include determining an engine power requirement of the load, and whether the engine power requirement of the load is sufficiently large to operate the engine in the low emissions mode. Additionally, the method may include operating the electric motor/generator if the engine power requirement of the load is not sufficiently large to operate the engine in the low emissions mode.

Abstract: A method of operating a drive system for a load is disclosed. The drive system may have an electric motor/generator and a gas turbine engine. The engine may have a combustor, and main and pilot flow paths via which fuel is supplied to the combustor. The engine may be operable in low and standard emissions modes. A proportion of the fuel that is supplied to the combustor via the pilot flow path may be greater in the standard emissions mode than in the low emissions mode. The method may include determining an engine power requirement of the load, and whether the engine power requirement of the load is sufficiently large to operate the engine in the low emissions mode. Additionally, the method may include operating the electric motor/generator if the engine power requirement of the load is not sufficiently large to operate the engine in the low emissions mode.

Abstract: This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N(C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

Abstract: A locking apparatus having a body, at least one arm and a tapered member; wherein relative movement between the arm and the tapered member extends the arm from the body. In use, the arm is arranged to press against a wall of a channel to hold the locking apparatus in place and prevent the opening of a roller shutter.

Abstract: The present invention is directed to solid, sustained-release, oral dosage form pharmaceutical compositions which contain therapeutic amounts of a pharmaceutically active agent, hydroxypropyl methyl cellulose and a non-ionic, hydrophilic polymer selected froth the group consisting of hydroxyethyl cellulose having a number average molecular weight ranging from 90,000 to 1,300,000, hydroxypropyl cellulose having a number average molecular weight of 370,000 to 1,500,000, and poly(ethylene oxide) having a number average molecular weight ranging from 100,000 to 500,000.

Abstract: The present disclosure generally relates to a fixation device for positioning and immobilizing at least two adjacent vertebrae. In particular, in one or more embodiments, the present disclosure relates to an anterior clivus plate that immobilizes at least two adjacent vertebrae.

Abstract: The present invention is directed to solid, sustained-release, oral dosage form pharmaceutical compositions which contain therapeutic amounts of a pharmaceutically active agent, hydroxypropyl methyl cellulose and a non-ionic, hydrophilic polymer selected from the group consisting of hydroxyethyl cellulose having a number average molecular weight ranging from 90,000 to 1,300,000, hydroxypropyl cellulose having a number average molecular weight of 370,000 to 1,500,000, and poly(ethylene oxide) having a number average molecular weight ranging from 100,000 to 500,000.

Abstract: A method of operating a drive system for a load is disclosed. The drive system may have an electric motor/generator and a gas turbine engine. The engine may have a combustor, and main and pilot flow paths via which fuel is supplied to the combustor. The engine may be operable in low and standard emissions modes. A proportion of the fuel that is supplied to the combustor via the pilot flow path may be greater in the standard emissions mode than in the low emissions mode. The method may include determining an engine power requirement of the load, and whether the engine power requirement of the load is sufficiently large to operate the engine in the low emissions mode. Additionally, the method may include operating the electric motor/generator if the engine power requirement of the load is not sufficiently large to operate the engine in the low emissions mode.

Abstract: This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n—-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N (C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

Abstract: This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N(C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

Abstract: A locking apparatus having a body, at least one arm and a tapered member; wherein relative movement between the arm and the tapered member extends the arm from the body. In use, the arm is arranged to press against a wall of a channel to hold the locking apparatus in place and prevent the opening of a roller shutter.

Abstract: The present invention relates to the field of improving nutritional content and more particularly the isoflavone content in plants. The invention provides a process for increasing the content of the isoflavone daidzein in selected plants, novel plants produced by this process and products derivable therefrom.

Abstract: A method of sterilising a protein in an aqueous environment, comprises exposing to ionising radiation an aqueous composition comprising the protein with a protective compound or combination of protective compounds having the following characteristics: (i) a rate of reaction with hydroxyl radicals greater than 5×108 L mol?1 s?1; and (ii) a non-polar region.

Abstract: A method is described for transmitting data from a mobile station to a wireless network, as is a wireless communications system that operates in accordance with the method. The method includes (a) requesting permission to transmit data using an access channel; (b) in response to receiving a permission message from the wireless network, transmitting the data from the mobile station to the wireless network over a control channel using a modulation and channel coding scheme determined in the wireless network, and communicated to mobile station in the permission message; and (c) in response to receiving the transmitted data at the wireless network, soft combining the received data with previously received data, if any, until a desired decoding result is achieved, and transmitting an acknowledgment of data reception to the mobile station. The steps of transmitting and receiving preferably use a code division, multiple access technique.

Abstract: This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discovered a group of 2-arylamino-7-(alkyl)oxy-8-alkylquinazolines and 8-alkyl-2-arylamino-quinazoline 2,7-diamines that are potent inhibitors of cyclin-dependent kinases (cdks). The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention also provides pharmaceutical formulations comprising at least one of the quinazoline compounds together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. The invention further provide useful intermediates generated during the production of the quinazoline compounds.

Abstract: A portable Dutch Oven stand comprising a low aspect ratio and few parts which are integrally pieced together into one transportable unit. In a preferred form the Dutch Oven Stand includes a tray for holding cooking fuel (typically charcoal briquettes) at a safe distance from the ground while also maintaining such fuel from falling onto the ground, and while also supporting at least one Dutch Oven during cooking. The Dutch Oven stand also comprises folding legs permanently attached to the tray, a leveling means forming a part of the tray to level the stand prior to cooking, and a rotatable platform assembly for rotating a Dutch Oven while on the stand without lifting the Dutch Oven from the stand.

Abstract: A process for preparing a 2-(pyridin-4-ylamino)-pyrido[2,3-d]pyrimidine of Formula II comprising reacting a 4-aminopyridine of the formula with an alkali metal amide or hydride and a 2-alkylsulfanyl-pyrido[2,3-d]pyrimidine of Formula I wherein R1, R2, R? and R?, and aryl are as defined in the specification.