Patents by Inventor Ru-Rong Ji

Ru-Rong Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210283163
    Abstract: Disclosed herein are miR-711 inhibitors. The miR-711 inhibitors may disrupt the binding of miR-711 to TRPA1. Further provided are methods of treating a disease or condition in a subject, methods of inhibiting miR-711, and methods of inhibiting TRPA1 in a subject. The methods may include administering to the subject a miR-711 inhibitor.
    Type: Application
    Filed: July 18, 2019
    Publication date: September 16, 2021
    Inventor: Ru-Rong Ji
  • Publication number: 20210268066
    Abstract: The present disclosure provides methods and kits for treating pain. More particularly, the present disclosure relates to methods of using PD-L1/PD-1-associated compounds to treat pain and/or bone destruction from bone cancer, and associated kits. The present disclosure also provides methods to assess the efficacy of compounds to suppress PD-1-associated nociceptive neuron activity.
    Type: Application
    Filed: May 11, 2021
    Publication date: September 2, 2021
    Applicant: Duke University
    Inventors: Ru-Rong Ji, Gang Chen, Zilong Wang, Changyu Jiang, Kaiyuan Wang
  • Publication number: 20210228499
    Abstract: Disclosed herein are methods and compositions for treating a disease or disorder in a subject in need thereof. The methods may include administering to the subject a therapeutically effective amount of a GPR37 agonist. The disease or disorder may be selected from inflammation, inflammatory pain, chronic pain, viral infection, bacterial infection, malaria, sepsis, or a combination thereof.
    Type: Application
    Filed: June 4, 2019
    Publication date: July 29, 2021
    Inventors: Ru-Rong Ji, Sangsu Bang, Zhen-Zhong Xu
  • Patent number: 11065259
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 20, 2021
    Assignees: Duke University, BioMimetix JV, LLC
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Patent number: 11007250
    Abstract: The present disclosure provides methods and kits for treating pain. More particularly, the present disclosure relates to methods of using PD-L1/PD-1-associated compounds to treat pain and/or bone destruction from bone cancer, and associated kits. The present disclosure also provides methods to assess the efficacy of compounds to suppress PD-1-associated nociceptive neuron activity.
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: May 18, 2021
    Assignee: Duke University
    Inventors: Ru-Rong Ji, Gang Chen, Zilong Wang, Changyu Jiang, Kaiyuan Wang
  • Publication number: 20200238019
    Abstract: Medicinal fluid delivery devices and methods for advancing and retracting needles are disclosed. According to an aspect, a medicinal fluid delivery device includes a tube that defines an interior space that extends between a first and second openings. The device includes a needle including a proximal end and a distal end that substantially align in a first direction. A portion of the distal end is biased to extend in a second direction different than the first direction. A mechanism is attached to the proximal end and configured to position the distal end between a first position and a second position. In the first position, the portion of the distal end is constrained by the interior wall such that is does not extend in the second direction. In the second position, the distal end is not constrained by the interior wall such that it extends in the second direction.
    Type: Application
    Filed: January 29, 2020
    Publication date: July 30, 2020
    Inventors: Kathleen Caroll, Ru-Rong Ji, Linda Gray-Leithe, Timothy Amrhein, Shivanand Lad
  • Publication number: 20200078443
    Abstract: The present disclosure provides methods and kits for treating pain. More particularly, the present disclosure relates to methods of using PD-L1/PD-1-associated compounds to treat pain and/or bone destruction from bone cancer, and associated kits. The present disclosure also provides methods to assess the efficacy of compounds to suppress PD-1-associated nociceptive neuron activity.
    Type: Application
    Filed: May 12, 2018
    Publication date: March 12, 2020
    Inventors: Ru-Rong Ji, Gang Chen, Zilong Wang, Changyu Jiang, Kaiyuan Wang
  • Publication number: 20190117697
    Abstract: Disclosed herein are bone marrow stromal cells. The bone marrow stromal cells may express and/or secrete TGF-?I. The bone marrow stromal cells may express CXCR4. Also disclosed herein is a method of treating pain in a subject in need thereof. The method of treating may include administration of the bone marrow stromal cells to the subject. The pain may be neuropathic pain.
    Type: Application
    Filed: July 8, 2016
    Publication date: April 25, 2019
    Inventors: Ru-Rong Ji, Gang Chen
  • Patent number: 10202450
    Abstract: Disclosed herein is an antibody that binds to a voltage sensor paddle (VSP) of Nav1.7. Also disclosed herein are methods of treating pain, itch, neurogenic inflammation, or cough in a subject in need thereof. The methods include administrating the antibody to the subject.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 12, 2019
    Assignee: Duke University
    Inventors: Seok-Yong Lee, Ru-Rong Ji
  • Publication number: 20180353516
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 13, 2018
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Patent number: 10080759
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: September 25, 2018
    Assignees: Duke University, BioMimetix J.V., LLC
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Publication number: 20160324868
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Application
    Filed: January 21, 2015
    Publication date: November 10, 2016
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Publication number: 20160237153
    Abstract: Disclosed herein is an antibody that binds to a voltage sensor paddle (VSP) of Nav1.7. Also disclosed herein are methods of treating pain, itch, neurogenic inflammation, or cough in a subject in need thereof. The methods include administrating the antibody to the subject.
    Type: Application
    Filed: September 5, 2014
    Publication date: August 18, 2016
    Inventors: Seok-Yong Lee, Ru-Rong Ji
  • Patent number: 9241991
    Abstract: This invention relates generally to a therapeutic use of TLR3 and TLR7 inhibitors to treat or reduce pruritus in a subject.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: January 26, 2016
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Ru-Rong Ji, Temugin Berta, Zhen-Zhong Xu, Tong Liu, Chul-Kyu Park
  • Publication number: 20130266588
    Abstract: This invention relates generally to a therapeutic use of TLR3 and TLR7 inhibitors to treat or reduce pruritus in a subject.
    Type: Application
    Filed: October 21, 2011
    Publication date: October 10, 2013
    Applicant: BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Ru-Rong Ji, Temugin Berta, Zhen-Zhong Xu, Tong Liu, Chul-Kyu Park
  • Publication number: 20120245229
    Abstract: The invention describes a method to treat neuropathic pain and/or inflammatory pain, comprising the step of administering to a subject in need thereof an effective amount of a resolvin, such that neuropathic pain and or inflammatory pain is treated.
    Type: Application
    Filed: September 15, 2010
    Publication date: September 27, 2012
    Inventors: Ru-Rong Ji, Charles N. Serhan
  • Publication number: 20080026003
    Abstract: The invention provides methods for the treatment or prevention of pain. The invention also provides screening methods for determining whether a compound inhibits IL-1? activity in the central nervous system of a mammal.
    Type: Application
    Filed: January 4, 2007
    Publication date: January 31, 2008
    Applicant: The General Hospital Corporation
    Inventors: Clifford Woolf, Tarek Samad, Ru-Rong Ji
  • Publication number: 20040105859
    Abstract: The invention provides methods for the treatment or prevention of pain. The invention also provides screening methods for determining whether a compound inhibits IL-1&bgr; activity in the central nervous system of a mammal.
    Type: Application
    Filed: December 15, 2003
    Publication date: June 3, 2004
    Inventors: Clifford J Woolf, Tarek A Samad, Ru-Rong Ji