Patents by Inventor Rudolf Schohe-Loop

Rudolf Schohe-Loop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6605255
    Abstract: The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: August 12, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Werner Kroll, Ferdinand Rombout, Horst Weber, Maria-Luisa Rodriguez, Bernd Sennhenn, Rudolf Schohe-Loop
  • Publication number: 20030060493
    Abstract: The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.
    Type: Application
    Filed: November 16, 2001
    Publication date: March 27, 2003
    Inventors: Werner Kroll, Ferdinand Rombout, Horst Weber, Maria-Luisa Rodriguez, Bernd Sennhenn, Rudolf Schohe-Loop
  • Publication number: 20010034451
    Abstract: Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with &bgr;-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.
    Type: Application
    Filed: February 12, 2001
    Publication date: October 25, 2001
    Inventors: Heinrich Meier, Wolfgang Hartwig, Bodo Junge, Rudolf Schohe-Loop, Zhan Gao, Bernard Schmidt, Maarten de Jonge, Teunis Schuurman
  • Patent number: 6239155
    Abstract: Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with &bgr;-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: May 29, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinrich Meier, Wolfgang Hartwig, Bodo Junge, Rudolf Schohe-Loop, Zhan Gao, Bernard Schmidt, Maarten de Jonge, Teunis Schuurman
  • Patent number: 6194428
    Abstract: The invention relates to the use of 5-substituted pyridine- and hexahydroquinoline-3-carboxylic acid derivatives, some of which are known, for the production of medicaments, in particular for the treatment of cerebral disorders.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: February 27, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
  • Patent number: 6174897
    Abstract: The present invention relates to bis-(quinolyl)-diamines of the general formula (I): in which the indicated substituents are as defined in the description. The invention also provides a process for the preparation of the compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: January 16, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Achim Feurer, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
  • Patent number: 6121284
    Abstract: The present invention relates to new 2,3-bridged 1,4-dihydropyridines of the general formula (I), ##STR1## in which R, R.sup.1, R.sup.2, D and E have the meaning given in the description, processes for their preparation and their use as medicaments, preferably for treatment of the central nervous system.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: September 19, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Siegfried Goldmann, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
  • Patent number: 6066655
    Abstract: 4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols.The new 4-phenyl-3-substituted 1,4-dihydropyridine esters can be employed as active compounds in medicaments for the treatment of the central nervous system, in particular as cerebral therapeutics.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: May 23, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinrich Meier, Wolfgang Hartwig, Bodo Junge, Rudolf Schohe-Loop, Zhan Gao, Bernard Schmidt, Maarten de Jonge, Teunis Schuurman
  • Patent number: 6060482
    Abstract: Triazaspirodecanone-methylchromans are prepared by reacting methylchromans, which are substituted on the methyl group by appropriate leaving groups, with triazaspirodecanones. The substances can be employed for the production of medicaments, in particular for medicaments for the control of disorders of the central nervous system.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: May 9, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Georg Heine, Rudolf Schohe-Loop, Thomas Glaser, Jean Marie Viktor de Vry, Wolfgang Dompert, Henning Sommermeyer
  • Patent number: 6001857
    Abstract: 4-Heterocyclyl-substituted dihydropyridines are prepared by reacting appropriate aldehydes with .beta.-keto esters and aminocrotonic acid esters, or by esterifying 4-heterocyclyl-substituted dihydropyridinecarboxylic acids. The 4-heterocyclyl-substituted dihydropyridines can be employed in medicaments, in particular for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: December 14, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Wolfgang Hartwig, Heinrich Meier, Rudolf Schohe-Loop, Zhan Gao, Bernard Schmidt, Maarten de Jonge, Teunis Schuurman
  • Patent number: 5962513
    Abstract: Diseases characterized by disturbances of the serotoninergic system, psychoses and depression are treated by administration of an aminomethyl-chroman of the formula ##STR1##
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: October 5, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Schohe-Loop, Hans-Georg Heine, Bodo Junge, Thomas Glaser, Jean Marie Viktor De Vry, Wolfgang Dompert, Henning Sommermeyer
  • Patent number: 5955482
    Abstract: The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: September 21, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Otto Behner, Siegfried Goldmann, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Egbert Wehinger, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
  • Patent number: 5942529
    Abstract: The benzisothiazolyl-substituted aminomethylchromans are prepared either by substituting the corresponding unsubstituted aminomethylchromans on the amine nitrogen or reacting the corresponding benzisothiazolylalkylamines with appropriate activated methylchromans or reacting the amine nitrogen of aminomethylchroman first with an appropriately substituted alkine and then hydrogenating. The benzisothiazolyl-substituted aminomethylchromans can be used as active compounds in medicaments, in particular in medicaments for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: August 24, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Schohe-Loop, Hans-Georg Heine, Peter-Rudolf Seidel, Wolfgang Kanhai, Joachim Schuhmacher, Arno Friedl, Ervin Horvath, Thomas Glaser, Reinhard Jork
  • Patent number: 5910593
    Abstract: The present invention relates to a new highly selective process for the preparation of enantiomerically pure halogeno-phenyl-substituted 1,4-dihydropyridine-3,5-dicarboxylic esters of the general formula (I) ##STR1## in which R.sup.1 to R.sup.3 have the meanings given in the description.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: June 8, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Mittendorf, Peter Fey, Bodo Junge, Johannes Kaulen, Kai van Laak, Heinrich Meier, Rudolf Schohe-Loop
  • Patent number: 5874438
    Abstract: The present invention relates to 2,2'-bridged bis-2,4-diaminoquinazolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides processes for the preparation of the compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.
    Type: Grant
    Filed: October 11, 1996
    Date of Patent: February 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Walter Hubsch, Achim Feurer, Hans-Georg Lerchen, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
  • Patent number: 5874462
    Abstract: The invention relates to the use of substituted 6-amino-4H-pyrans for the production of medicaments for the treatment of cerebral disorders, in particular of degenerative disorders such as dementia, and also for treatment of depressions and psychoses. New active compounds are prepared by reaction of the corresponding ylidene compounds with malononitrile.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: February 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
  • Patent number: 5866562
    Abstract: The present invention relates to ring-bridged bis-quinolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides a process for the preparation of compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: February 2, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Achim Feurer, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
  • Patent number: 5861394
    Abstract: The invention relates to the use of N-substituted phenothiazines for the production of medicaments for the treatment of cerebral disorders. The invention likewise relates to novel active compounds which are prepared by reaction of phenothiazine with the appropriate acids, esters or amides or by reaction of the phenothiazinecarbonyl halides with amines. The active compounds are particularly suitable for the treatment of dementias and age-related leaning and memory disorders and depressions.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: January 19, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de vry
  • Patent number: 5849924
    Abstract: The present invention relates to a new highly selective process for the preparation of enantiomerically pure halogeno-phenyl-substituted 1,4-dihydropyridine-3,5-dicarboxylic esters of the general formula (I) ##STR1## in which R.sup.1 to R.sup.3 have the meanings given in the description.
    Type: Grant
    Filed: July 16, 1997
    Date of Patent: December 15, 1998
    Assignee: Bayer Aktiengesellscahft
    Inventors: Joachim Mittendorf, Peter Fey, Bodo Junge, Johannes Kaulen, Kai van Laak, Heinrich Meier, Rudolf Schohe-Loop
  • Patent number: RE36607
    Abstract: This invention relates to benzolididene compounds of the formula ##STR1## in which R.sup.2 represents the radical ##STR2## in which R.sup.4 and R.sup.5 are identical or different and denote halogen, cyano, ethinyl, trifluoromethoxy, methylthio, nitro, trifluoromethyl or straight-chain or branched alkyl, alkenyl, alkinyl or alkoxy having up to 4 carbon atoms, and one of the substituents optionally represents hydrogen,or a salt thereof.[...]..Iadd., andA represents hydrogen or straight-chain or branched alkyl having up to 8 carbon atoms, or represents phenyl or benzyl which are optionally substituted one to three times by identical or different substituents from the series consisting of hydroxyl, nitro, halogen, cyano, carboxyl, trifluoromethyl, trifluoromethoxy, straight-chain or branched alkoxy having up to 6 carbon atoms or by a group of the formula --NR.sup.6 R.sup.7 or --SO.sub.2 R.sup.8, in whichR.sup.6 and R.sup.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: March 7, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Mittendorf, Peter Fey, Bodo Junge, Johannes Kaulen, Kai van Laak, Heinrich Meier, Rudolf Schohe-Loop