Patents by Inventor Rudolf Seidel
Rudolf Seidel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6174897Abstract: The present invention relates to bis-(quinolyl)-diamines of the general formula (I): in which the indicated substituents are as defined in the description. The invention also provides a process for the preparation of the compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.Type: GrantFiled: October 25, 1996Date of Patent: January 16, 2001Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Achim Feurer, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
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Patent number: 5942529Abstract: The benzisothiazolyl-substituted aminomethylchromans are prepared either by substituting the corresponding unsubstituted aminomethylchromans on the amine nitrogen or reacting the corresponding benzisothiazolylalkylamines with appropriate activated methylchromans or reacting the amine nitrogen of aminomethylchroman first with an appropriately substituted alkine and then hydrogenating. The benzisothiazolyl-substituted aminomethylchromans can be used as active compounds in medicaments, in particular in medicaments for the treatment of disorders of the central nervous system.Type: GrantFiled: June 13, 1996Date of Patent: August 24, 1999Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe-Loop, Hans-Georg Heine, Peter-Rudolf Seidel, Wolfgang Kanhai, Joachim Schuhmacher, Arno Friedl, Ervin Horvath, Thomas Glaser, Reinhard Jork
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Patent number: 5874438Abstract: The present invention relates to 2,2'-bridged bis-2,4-diaminoquinazolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides processes for the preparation of the compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.Type: GrantFiled: October 11, 1996Date of Patent: February 23, 1999Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Walter Hubsch, Achim Feurer, Hans-Georg Lerchen, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
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Patent number: 5866562Abstract: The present invention relates to ring-bridged bis-quinolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides a process for the preparation of compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.Type: GrantFiled: October 25, 1996Date of Patent: February 2, 1999Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Achim Feurer, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
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Patent number: 5760230Abstract: 4,4'-Bridged bis-2,4-diaminoquinazolines of the general formula (I) ##STR1## processes for their preparation and use as agents acting on the potassium channels of the brain.Type: GrantFiled: October 11, 1996Date of Patent: June 2, 1998Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Achim Feurer, Hans-Georg Lerchen, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
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Patent number: 5756517Abstract: The present invention relates to the use of bisquinolines of the general formula ##STR1## in which the substituents mentioned have the meanings given in the description.The invention furthermore relates to new bisquinolines of the general formula (I), to a process for the preparation of the known and the new bisquinolines, to the use of the new bisquinolines as medicaments, to their use for the preparation of medicaments, and to medicaments comprising them.Type: GrantFiled: October 25, 1996Date of Patent: May 26, 1998Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Achim Feurer, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
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Patent number: 5739127Abstract: The present invention provides 2,4'-bridged bis-2,4-diaminoquinazolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides a process for the preparation of the compounds of the formula (I), drugs containing said compounds and processes for the preparation of drugs containing said compounds.Type: GrantFiled: November 8, 1996Date of Patent: April 14, 1998Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe-Loop, Peter-Rudolf Seidel, William Bullock, Gabriele Handke, Achim Feurer, Wolfgang Roben, Georg Terstappen, Joachim Schuhmacher, Franz-Josef van der Staay, Bernard Schmidt, Richard J. Fanelli, Jane C. Chisholm, Richard T. McCarthy
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Patent number: 5585392Abstract: The method of treating stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.Type: GrantFiled: June 7, 1995Date of Patent: December 17, 1996Assignee: Bayer AktiengesellschaftInventors: Bodo Junge, Rudolf Schohe, Peter-Rudolf Seidel, Thomas Glaser, J org Traber, Ulrich Benz, Teunis Schuurman, Jean-Marie Viktor De Vry
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Patent number: 5506246Abstract: A method of treating depression or stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## and R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.Type: GrantFiled: December 21, 1993Date of Patent: April 9, 1996Assignee: Bayer AktiengesellschaftInventors: Bodo Junge, Rudolf Schohe, Peter-Rudolf Seidel, Thomas Glaser, Jorg Traber, Ulrich Benz, Teunis Schuurman, Jean-Marie V. De Vry
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Patent number: 5453437Abstract: Novel 1,3-disubstituted pyrrolidines active on the central nervous system of the formula ##STR1## wherein A--denotes phenyl or hetaryl, which is optionally fused with aromatic, saturated or unsaturated cyclic or heterocyclic hydrocarbons, where this radical can optionally be substituted,X--denotes --O--CH.sub.2 --, --CH.sub.2 --O-- or --0--,n--denotes a number from 1 to 19, andB--denotes cyano or a group of the formula --COOR.sup.1, --CONR.sup.2 R.sup.3, --SO.sub.2 NR.sup.2 R.sup.3, --SO.sub.m R.sup.4, --NR.sup.5 R.sup.6, or --C.tbd.C--CH.sub.2 --NR.sup.5 R.sup.6,and salts thereof.Type: GrantFiled: September 8, 1993Date of Patent: September 26, 1995Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe, Peter-Rudolf Seidel, Jorg Traber, Thomas Glaser
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Patent number: 5326771Abstract: Piperidylmethyl-substituted chroman derivatives can be prepared by first reducing corresponding chromancarboxylic acid derivatives, if appropriate with prior activation, with the cyclic amines and then reducing the carbonyl group, or by reacting chromanmethyl compounds directly with the cyclic amines. The substituted piperidylmethyl-substituted chroman derivatives can be employed as active compounds in medicaments, in particular for the treatment of diseases of the central-nervous system.Type: GrantFiled: November 30, 1992Date of Patent: July 5, 1994Assignee: Bayer AktiengesellschaftInventors: Hans-Georg Heine, Bodo Junge, Peter-Rudolf Seidel, Rudolf Schohe-Loop, Thomas Glaser, Jean M. V. De Vry, Wolfgang Dompert, Henning Sommermeyer
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Patent number: 5314884Abstract: The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.Type: GrantFiled: August 31, 1992Date of Patent: May 24, 1994Assignee: Troponwerke GmbH & Co.Inventors: Peter-Rudolf Seidel, Harald Horstmann, Jorg Traber, Wolfgang Dompert, Thomas Glaser, Teunis Schuurman
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Patent number: 5300523Abstract: For binding 5-HT.sub.Type: GrantFiled: April 7, 1992Date of Patent: April 5, 1994Assignee: Bayer AktiengesellschaftInventors: Bodo Junge, Rudolf Schohe, Peter-Rudolf Seidel, Thomas Glaser, Jorg Traber, Ulrich Benz, Teunis Schuurman, Jean-Marie Viktor De Vry
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Patent number: 5274097Abstract: Novel 1,3-disubstituted pyrrolidines active on the central nervous system of the formula ##STR1## wherein A--denotes phenyl or hetaryl, which is optionally fused with aromatic, saturated or unsaturated cyclic or heterocyclic hydrocarbons, where this radical can optionally be substituted,X--denotes --O--CH.sub.2 --, --CH.sub.2 --O-- or --O--,n--denotes a number from 1 to 19, andB--denotes cyano or a group of the formula --COOR.sup.1, --CONR.sup.2 R.sup.3, --SO.sub.2 NR.sup.2 R.sup.3, --SO.sub.m R.sup.4, --NR.sup.5 R.sup.6, or --C.tbd.C--CH.sub.2 --NR.sup.5 R.sup.6,and salts thereof.Type: GrantFiled: April 9, 1991Date of Patent: December 28, 1993Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe, Peter-Rudolf Seidel, Jorg Traber, Thomas Glaser
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Patent number: 5187276Abstract: The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.Type: GrantFiled: November 28, 1990Date of Patent: February 16, 1993Assignee: Troponwerke GmbH & Co. KG.Inventors: Peter-Rudolf Seidel, Harald Horstmann, Jorg Traber, Wolfgang Dompert, Thomas Glaser, Teunis Thurman
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Patent number: 5137901Abstract: For binding 5-HT.sub.1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.Type: GrantFiled: September 26, 1989Date of Patent: August 11, 1992Assignee: Bayer AktiengesellschaftInventors: Bodo Junge, Rudolf Schohe, Peter-Rudolf Seidel, Thomas Glaser, Jorg Traber, Ulrich Benz, Teunis Schuurman, Jean-Marie V. De Vry
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Patent number: 5037841Abstract: Novel 1,3-disubstituted pyrrolidines active on the central nervous system of the formula ##STR1## wherein A denotes phenyl or hetaryl, which is optionally fused with aromatic, saturated or unsaturated cyclic or heterocyclic hydrocarbons, where this radical can optionally be substituted,X denotes --O--CH.sub.2 --, --CH.sub.2 --O-- or --O--,n denotes a number from 1 to 19, andB denotes cyano or a group of the formula --COOR.sup.1, --CONR.sup.2 R.sup.3, --SO.sub.2 NR.sup.2 R.sup.3, --SO.sub.m R.sup.4, --NR.sup.5 R.sup.6, or --C.tbd.C--CH.sub.2 --NR.sup.5 R.sup.6,and salts thereof.Type: GrantFiled: April 12, 1989Date of Patent: August 6, 1991Assignee: Bayer AktiengesellschaftInventors: Rudolf Schohe, Peter-Rudolf Seidel, Jorg Traber, Thomas Glaser
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Patent number: 4988809Abstract: The invention relates to substituted 2-pyrimidinyl-1- piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.Type: GrantFiled: February 21, 1990Date of Patent: January 29, 1991Assignee: Troponwerke GmbH & Co., KGInventors: Peter-Rudolf Seidel, Harald Horstmann, Jorg Traber, Wolfgang Dompert, THomas Glaser, Teunis Schuurmann
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Patent number: 4937343Abstract: The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.Type: GrantFiled: September 22, 1988Date of Patent: June 26, 1990Assignee: Troponwerke GmbH & Co. KGInventors: Peter-Rudolf Seidel, Harald Horstmann, Jorg Traber, Wolfgang Dompert, Thomas Glaser, Teunis Schuurman
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Patent number: 4818756Abstract: The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.Type: GrantFiled: March 10, 1986Date of Patent: April 4, 1989Assignee: Troponwerke GmbH & Co., KGInventors: Peter-Rudolf Seidel, Harald Horstmann, Jorg Traber, Wolfgang Dompert, Thomas Glaser, Teunis Schuurman