Abstract: Provided are catechol nanoparticles, catechol protein nanoparticles, and a preparation method and use thereof. The method includes: adding a tannin compound-containing natural herb medicine into water to obtain a mixture, and subjecting the mixture to heating reflux extraction to obtain a herb medicine extract and subjecting the herb medicine extract to fractionation to obtain the catechol nanoparticles.

Abstract: Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

Abstract: Embodiments of the invention provide multilayer analyte sensors having elements and/or architectures that function to improve oxygen delivery to sensor enzymes in manner that enhances sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract: A system and method for using super geo-fences to improve efficiency of geo-fences is disclosed. A system determines a geo-fence density based on a number of geo-fences in an area around a client system. In response to determining the geo-fence density is greater than a predetermined density value, the system selects a number of geo-fences that is greater than a fixed number of geo-fences that the client system is capable of handling. The system groups the selected geo-fences into a first and second group of geo-fences and generates a super geo-fence that encompasses the first group. The system transmits the first and second group of geo-fences and the super geo-fence to an application stored at the client device. The application adds geo-fence data corresponding to the second group to the client system in response to detecting the client system crossing a boundary of the super geo-fence.

Abstract: In various example embodiments, a system and method for enhancing a user's on-line experience by utilizing a computer-implemented on-line session trace system is provided. The on-line session trace system is provided in connection with an on-line trading platform. The on-line session trace system records and stores a state of an on-line session associated with a user identification and permits a user associated with the user identification to commence a further on-line session from a state corresponding to the saved state of a previous on-line session.

Abstract: Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

Abstract: In various example embodiments, a system and method for enhancing a user's on-line experience by utilizing a computer-implemented on-line session trace system is provided. The on-line session trace system is provided in connection with an on-line trading platform. The on-line session trace system records and stores a state of an on-line session associated with a user identification and permits a user associated with the user identification to commence a further on-line session from a state corresponding to the saved state of a previous on-line session.

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

Abstract: The present invention provides a class of novel compounds having Btk selective inhibitory activity, better metabolic stability and the like.

Abstract: A system and method for using time to reach determinations to improve the usability of geo-fences is disclosed. A computer system accesses a current location of a client system and identifies one or more nearby geo-fences. The computer system then calculates the time to reach each of these geo-fences. If the calculated time to reach value for a particular geo-fence is within the notification range associated with that geo-fence, then the computer system generates a notification to display to a user.

Abstract: The invention disclosed herein includes electrode compositions formed from processes that sputter metal in a manner that produces pillar architectures. Embodiments of the invention can be used in analyte sensors having such electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals. However, the metal pillar structures have wide ranging applicability and should increase surface area and decrease charge density for catalyst layers or electrodes used with sensing, power generation, recording, and stimulation, in vitro and/or in the body, or outside the body.

Abstract: In various example embodiments, a system and method for enhancing a user's on-line experience by utilizing a computer-implemented on-line session trace system is provided. The on-line session trace system is provided in connection with an on-line trading platform. The on-line session trace system records and stores a state of an on-line session associated with a user identification and permits a user associated with the user identification to commence a further on-line session from a state corresponding to the saved state of a previous on-line session.

Abstract: A system and method for using super geo-fences to improve efficiency of geo-fences is disclosed. A server system determines a geo-fence density based on a number of geo-fences in an area around a client system. In response to determining the geo-fence density is greater than a predetermined density value, the server system selects a number of geo-fences that is greater than a fixed number of geo-fences that the client system is capable of handling. The server system groups the selected geo-fences into a first and second group of geo-fences and generates a super geo-fence that encompasses the first group. The server system transmits the first and second group of geo-fences and the super geo-fence to an application stored at the client device. the application adds geo-fence data corresponding to the second group to the client system in response to detecting the client system crossing a boundary of the super geo-fence.

Abstract: The invention disclosed herein includes electrode compositions formed from processes that sputter metal in a manner that produces pillar architectures. Embodiments of the invention can be used in analyte sensors having such electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals. However, the metal pillar structures have wide ranging applicability and should increase surface area and decrease charge density for catalyst layers or electrodes used with sensing, power generation, recording, and stimulation, in vitro and/or in the body, or outside the body.

Abstract: A system and method for using super geo-fences to improve efficiency of geo-fences is disclosed. A server system determines a geo-fence density based on a number of geo-fences in an area around a client system. In response to determining the geo-fence density is greater than a predetermined density value, the server system selects a number of geo-fences that is greater than a fixed number of geo-fences that the client system is capable of handling. The server system groups the selected geo-fences into a first and second group of geo-fences and generates a super geo-fence that encompasses the first group. The server system transmits the first and second group of geo-fences and the super geo-fence to an application stored at the client device. The application adds geo-fence data corresponding to the second group to the client system in response to detecting the client system crossing a boundary of the super geo-fence.

Abstract: In various example embodiments, a system and method for enhancing a user's on-line experience by utilizing a computer-implemented on-line session trace system is provided. The on-line session trace system is provided in connection with an on-line trading platform. The on-line session trace system records and stores a state of an on-line session associated with a user identification and permits a user associated with the user identification to commence a further on-line session from a state corresponding to the saved state of a previous on-line session.

Abstract: A system and method for using time to reach determinations to improve the usability of geo-fences is disclosed. A computer system accesses a current location of a client system and identifies one or more nearby geo-fences. The computer system then calculates the time to reach each of these geo-fences. If the calculated time to reach value for a particular geo-fence is within the notification range associated with that geo-fence, then the computer system generates a notification to display to a user.

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

Abstract: Embodiments of the invention provide multilayer analyte sensors having elements and/or architectures that function to improve oxygen delivery to sensor enzymes in manner that enhances sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.