Abstract: In various example embodiments, a system and method for enhancing a user's on-line experience by utilizing a computer-implemented on-line session trace system is provided. The on-line session trace system is provided in connection with an on-line trading platform. The on-line session trace system records and stores a state of an on-line session associated with a user identification and permits a user associated with the user identification to commence a further on-line session from a state corresponding to the saved state of a previous on-line session.

Abstract: A system and method for using time to reach determinations to improve the usability of geo-fences is disclosed. A computer system accesses a current location of a client system and identifies one or more nearby geo-fences. The computer system then calculates the time to reach each of these geo-fences. If the calculated time to reach value for a particular geo-fence is within the notification range associated with that geo-fence, then the computer system generates a notification to display to a user.

Abstract: Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

Abstract: In various example embodiments, a system and method for enhancing a user's on-line experience by utilizing a computer-implemented on-line session trace system is provided. The on-line session trace system is provided in connection with an on-line trading platform. The on-line session trace system records and stores a state of an on-line session associated with a user identification and permits a user associated with the user identification to commence a further on-line session from a state corresponding to the saved state of a previous on-line session.

Abstract: A system and method for using super geo-fences to improve efficiency of geo-fences is disclosed. A server system determines a geo-fence density based on a number of geo-fences in an area around a client system. In response to determining the geo-fence density is greater than a predetermined density value, the server system selects a number of geo-fences that is greater than a fixed number of geo-fences that the client system is capable of handling. The server system groups the selected geo-fences into a first and second group of geo-fences and generates a super geo-fence that encompasses the first group. The server system transmits the first and second group of geo-fences and the super geo-fence to an application stored at the client device. The application adds geo-fence data corresponding to the second group to the client system in response to detecting the client system crossing a boundary of the super geo-fence.

Abstract: The present invention provides a class of novel compounds having Btk selective inhibitory activity, better metabolic stability and the like.

Abstract: A system and method for using super geo-fences to improve efficiency of geo-fences is disclosed. A server system determines a geo-fence density based on a number of geo-fences in an area around a client system. In response to determining the geo-fence density is greater than a predetermined density value, the server system selects a number of geo-fences that is greater than a fixed number of geo-fences that the client system is capable of handling. The server system groups the selected geo-fences into a first and second group of geo-fences and generates a super geo-fence that encompasses the first group. The server system transmits the first and second group of geo-fences and the super geo-fence to an application stored at the client device. The application adds geo-fence data corresponding to the second group to the client system in response to detecting the client system crossing a boundary of the super geo-fence.

Abstract: Various examples are provided for electrokinetic dewatering of e.g., phosphatic clay suspensions. In one example, among others, a system includes a separation chamber including an anode and a cathode extending ends of the separation chamber and a power supply configured to energize the anode and the cathode to establish an electric field. An inlet at one end of the separation chamber can supply a dilute feed suspension and an outlet at another end of the separation chamber can remove supernatant water. The electric field can consolidate solids in the dilute feed suspension. Consolidated solids may be removed by a removal mechanism. In another example, a method includes supplying a dilute feed suspension including suspended solids, establishing an electric field to consolidate solids, and removing supernatant water.

Abstract: A system may identify attributes of a geofence surrounding a location. The attributes of the geofence may represent merchant characteristics of a brick-and-mortar store and may further represent item characteristics of merchandise items available for sale from the brick-and-mortar store. A subset of users from a plurality of users eligible to receive the geofence may be selected based at least in part on matching the attributes of the geofence to preferences associated with each user among the subset of users. Geofence data representing the geofence may be sent to each of the client devices operated by the subset of the plurality of users. An indication may be received from a client device operated by a user of the user crossing into the geofence based on the geofence data. Lastly, a notification may be presented to the client device operated by the user.

Abstract: An apparatus and method for determining time-dependence failure under constant temperature through high pressure true triaxial loading for hard rock, includes a pressure chamber and four actuators, wherein a sample bearing platform is arranged in a center of the pressure chamber, a sample bearing and containing chamber is arranged in a center of the sample bearing platform, and a confining pressure loading oil supply hole is formed in the sample bearing platform, and communicates with a confining pressure loading injection pump; each actuator includes a sealing cover, an annular end cover, a counter-force cylinder barrel, a piston, a piston rod, a sealing flange and a stress loading injection pump; a heating coil is arranged in the pressure chamber; a force sensor is fixedly mounted at the end part of the piston rod; and a pressure sensor is mounted in the sample bearing platform.

Abstract: A high-pressure true triaxial test apparatus with capacity of low-frequency disturbance and high-speed impact includes static and dynamic loading frames, four static loading actuators, two dynamic loading actuators and an SHPB mechanism, wherein all actuators are connected with a hydraulic station system; a hollow way is formed in the axial center of each piston shaft of the dynamic loading actuators, a dynamic pressure sensor adopting a hollow ring structure is mounted at the end part of each piston shaft, and the SHPB mechanism applies a high-speed impact load on a rock sample through the dynamic pressure sensors respectively; and the dynamic loading actuators adopt a static pressure oilway balance support sealing manner and are connected with the hydraulic station system, each oilway is provided with an energy accumulator, and flow is increased by the servo valves to drive pistons to perform dynamic response.

Abstract: A system may identify attributes of a geofence surrounding a location. The attributes of the geofence may represent merchant characteristics of a brick-and-mortar store and may further represent item characteristics of merchandise items available for sale from the brick-and-mortar store. A subset of users from a plurality of users eligible to receive the geofence may be selected based at least in part on matching the attributes of the geofence to preferences associated with each user among the subset of users. Geofence data representing the geofence may be sent to each of the client devices operated by the subset of the plurality of users. An indication may be received from a client device operated by a user of the user crossing into the geofence based on the geofence data. Lastly, a notification may be presented to the client device operated by the user.

Abstract: Various methods and systems are provided for electrokinetic dewatering of suspensions such as, e.g., phosphatic clay. In one example, among others, a system for continuous dewatering includes a cake formation zone including a first anode and a first cathode each extending across a first portion of a separation chamber; a cake dewatering zone including a second anode and a second cathode; an inlet configured to supply a dilute feed suspension comprising solids suspended in water to the cake formation zone; and a conveying belt extending between the first anode and the first cathode and between the second anode and the second cathode. A first electric field between the first anode and the first cathode forms a cake on the conveying belt by consolidating the solids, and a second electric field between the second anode and the second cathode dewaters the cake on the conveying belt.

Abstract: A plurality of location data points is collected by a system, each location data point of the plurality of location data points corresponding to a request received at a central server from a user device of a user among a group of users. A geographic heatmap is created based on the collected plurality of location data points, the geographic heatmap identifying density distributions of the plurality of location data points, the density distributions being concentrations of the location data points included in each of a plurality of identified locations. The density distributions are analyzed within the geographic heatmap to identify a target location from one of the plurality of identified locations with a density profile including parameters exceeding one or more pre-defined thresholds. A geofence is generated around the target location, the geofence enabling detection of target users for distributions of promotional publications associated with the target location.

Abstract: A system and method for using super geo-fences to improve efficiency of geo-fences is disclosed. A server system determines a geo-fence density based on a number of geo-fences in an area around a client system. In response to determining the geo-fence density is greater than a predetermined density value, the server system selects a number of geo-fences that is greater than a fixed number of geo-fences that the client system is capable of handling. The server system groups the selected geo-fences into a first and second group of geo-fences and generates a super geo-fence that encompasses the first group. The server system transmits the first and second group of geo-fences and the super geo-fence to an application stored at the client device. the application adds geo-fence data corresponding to the second group to the client system in response to detecting the client system crossing a boundary of the super geo-fence.

Abstract: A system and method for using time to reach determinations to improve the usability of geo-fences is disclosed. A computer system accesses a current location of a client system and identifies one or more nearby geo-fences. The computer system then calculates the time to reach each of these geo-fences. If the calculated time to reach value for a particular geo-fence is within the notification range associated with that geo-fence, then the computer system generates a notification to display to a user.

Abstract: The present application relates to a method for preparing Ibutinib as shown by the following synthetic route and the intermediate compounds involved therein.

Abstract: The invention disclosed herein includes electrode compositions formed from processes that sputter metal in a manner that produces pillar architectures. Embodiments of the invention can be used in analyte sensors having such electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals. However, the metal pillar structures have wide ranging applicability and should increase surface area and decrease charge density for catalyst layers or electrodes used with sensing, power generation, recording, and stimulation, in vitro and/or in the body, or outside the body.

Abstract: A system and method for using super geo-fences and virtual fences to improve efficiency of geo-fences is disclosed. A server system stores geo-fence data for a plurality of geo-fences and receives a request for updated geo-fence data from a client system. The server system selects one or more geo-fences and generates a super geo-fence that encompasses all the selected geo-fences. The server system determines a super geo-fence reduction factor. The server system reduces the size of the super geo-fence based on the determined reduction factor. The server system then transmits the generated super geo-fence and the selected one or more geo-fences to the client system.

Abstract: A system and method for using time to reach determinations to improve the usability of geo-fences is disclosed. A computer system accesses a current location of a client system and identifies one or more nearby geo-fences. The computer system then calculates the time to reach each of these geo-fences. If the calculated time to reach value for a particular geo-fence is within the notification range associated with that geo-fence, then the computer system generates a notification to display to a user.