Abstract: Detectors and detection systems are disclosed. According to certain embodiments, a substrate comprises a plurality of sensing elements including a first plurality of the sensing elements and a second plurality of the sensing elements, and a plurality of sections configured to connect the first plurality to an output, and connect the second plurality to an output. Switching regions may be provided between the sensing elements that are configured to connect two or more sensing elements. The switching region may be controlled based on signals generated in response to the sensing elements receiving electrons with a predetermined amount of energy and/or beam intensity.

Abstract: The present invention provides use of Tadalafil as a protein arginine methyltransferase 5 (PRMT5) inhibitor. The present invention finds out that Tadalafil is a PRMT5 inhibitor by virtually screening active compounds targeting PRMT5 based on crystal structure and information about active sites of PRMT5. The present invention not only confirms that Tadalafil can inhibit an enzymatic activity of PRMT5, but also confirms that Tadalafil alone can inhibit tumor growth in breast cancer and improve sensitivity to chemotherapy for breast cancer.

Abstract: The present disclosure describes an image forming element having a semiconductor chip with micro-electro-mechanical-system (MEMS) devices and voltage generators, each voltage generator being configured to generate a voltage used by one or more of the MEMS devices. A floating ground may be used to add a voltage to the voltage generated by the voltage generators. The semiconductor chip may include electrical connections, where each voltage generator is configured to provide the voltage to the one or more MEMS devices through the electrical connections. The MEMS devices may define a boundary in the semiconductor chip within which the MEMS devices, the voltage generators, and the electrical connections are located. Each MEMS device may generate an electrostatic field to manipulate an electron beamlet of a multi-beam charged particle microscope. The MEMS devices may be organized into groups based on a distance to a reference location (e.g., optical axis) in the semiconductor chip.

Abstract: A detector may be provided with a sensing element or an array of sensing elements, each of the sensing elements may have a corresponding gain element. A substrate may be provided having a sensing element and a gain element integrated together. The gain element may include a section in which, along a direction perpendicular to an incidence direction of an electron beam, a region of first conductivity is provided adjacent to a region of second conductivity, and a region of third conductivity may be provided adjacent to the region of second conductivity. The sensing element may include a section in which, along the incidence direction, a region of fourth conductivity is provided adjacent to an intrinsic region of the substrate, and the region of second conductivity may be provided adjacent to the intrinsic region.

Abstract: Systems and methods for implementing a detector array are disclosed. According to certain embodiments, a substrate comprises a plurality of sensing elements including a first element and a second element. The detector comprises a switching element configured to connect the first element and the second element. The switching region may be controlled based on signals generated in response to the sensing elements receiving electrons with a predetermined amount of energy.

Abstract: Systems and methods for implementing a detector array are disclosed. According to certain embodiments, a substrate comprises a plurality of sensing elements including a first element and a second element. The detector comprises a switching element configured to connect the first element and the second element. The switching region may be controlled based on signals generated in response to the sensing elements receiving electrons with a predetermined amount of energy.

Abstract: A pasta roller with a built-in motor for manual and electric pasta roller machine includes a first shaft and a direct current motor received in a main roller. The first shaft is fixed to the main roller. The direct current motor drives the first shaft in one direction via a planetary reduction gear unit. A second shaft is co-axially located in the main roller and has a first end gear mounted thereto. A secondary roller is located beside the main roller and has a second end gear connected to one end thereof. The first and second end gears are engaged with each other. A crank is removably inserted into a hole in the first shaft. When in manual operation, the crank is rotated to rotate the main roller and the second shaft, and the secondary roller is rotated by the engagement between the first and second end gears.

Abstract: A detector may be provided with an array of sensing elements. The detector may include a semiconductor substrate including the array, and a circuit configured to count a number of charged particles incident on the detector. The circuit of the detector may be configured to process outputs from the plurality of sensing elements and increment a counter in response to a charged particle arrival event on a sensing element of the array. Various counting modes may be used. Counting may be based on energy ranges. Numbers of charged particles may be counted at a certain energy range and an overflow flag may be set when overflow is encountered in a sensing element. The circuit may be configured to determine a time stamp of respective charged particle arrival events occurring at each sensing element. Size of the sensing element may be determined based on criteria for enabling charged particle counting.

Abstract: A power source supply system for a magnetic resonance imaging (MRI) apparatus that has multiple loads operating in a magnetic field environment, has an AC/DC conversion circuit that converts a supplied AC current to a first DC current having a predetermined first voltage, a branching element that supplies the first DC current in separate paths respectively to the multiple loads, a switching power source, disposed in each of the loads that converts the first DC current to a second DC current having a second voltage capable of being supplied to the load, with a switching frequency of the switching power source being set such that a positive integer frequency multiple thereof is offset from the Larmor frequency of the MRI apparatus.

Abstract: A pasta roller with a built-in motor for manual and electric pasta roller machine includes a first shaft and a Direction Current motor received in a main roller. The first shaft is fixed to the main roller. The Direction Current motor drives the first shaft in one direction via a planet reduction gear unit. A second shaft is co-axially located in the main roller and has a first end gear mounted thereto. A secondary roller is located beside the main roller and has a second end gear connected to one end thereof. The first and second end gears are engaged with each other. A crank is removably inserted into a hole in the first shaft. When in manual operation, the crank is rotated to rotate the main roller and the second shaft, and the secondary roller is rotated by the engagement between the first and second end gears.

Abstract: By making use of two common-source amplifying units having a shared DC bias in conjunction with two current units or an extra amplifying unit, a power amplifier is capable of providing a high output power in a high power-gain operation and achieving a low power biasing consumption in a low power-gain operation. The two current units are utilized to provide auxiliary bias currents for diverting part of two bias currents corresponding to the shared DC bias for the two amplifying units so that the output power can be boosted in the high power-gain operation. Also, the extra amplifying unit can be coupled in series with the two amplifying units for improving the output power of the power amplifier in the high power-gain operation. The shared DC bias provides same bias current to the two amplifying units for achieving the low power biasing consumption in the low power-gain operation.