Abstract: An injection molding apparatus (5) comprising a clamp plate (80), a heated manifold (20), an actuator (10) interconnected to a valve pin (17) drivable along an axis (A), a mold (300) and a cooling device (500) that cools the actuator, the actuator (10) comprising a thermally conductive housing body (12) that is mounted in direct heat or thermally conductive contact with one or more insulators (60, 50) that are in turn mounted in direct heat conductive contact or communication with the manifold (20), the cooling device (500) comprising a heat transmitter comprised of an arm (502) comprised of a thermally conductive material having a distal end surface (502s) for making thermally conductive contact with the clamp plate (80), the proximal surface (502b) of the arm (502) being slidably engageable against a complementary surface (12ls) of the actuator that is spaced laterally (12ld) from the valve pin axis (A) for transmitting heat from the housing body (12) to the proximal surface (502b) and in turn to the dis

Abstract: An injection molding apparatus (5) comprising a clamp plate (80), a heated manifold (20), an actuator (10) interconnected to a valve pin (17) drivable along an axis (A), a mold (300) and a cooling device (500) that cools the actuator, the actuator (10) comprising a thermally conductive housing body (12) that is mounted in direct heat or thermally conductive contact with one or more mounts (60, 50, 803) that are in turn mounted in direct heat conductive contact or communication with the manifold (20), the cooling device (500) comprising a heat transmitter comprised of an arm (502) comprised of a thermally conductive material having a distal end surface (502s) for making thermally conductive contact with the clamp plate (80), the proximal surface (502b) of the arm (502) being slidably engageable against a complementary surface (12ls) of the actuator that is spaced laterally (12ld) from the valve pin axis (A) for transmitting heat from the housing body (12) to the proximal surface (502b) and in turn to the di

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.

Abstract: An injection molding apparatus (5) comprising a clamp plate (80), a heated manifold (20), an actuator (10) interconnected to a valve pin (17) drivable along an axis (A), a mold (300) and a cooling device (500) that cools the actuator, the actuator (10) comprising a thermally conductive housing body (12) that is mounted in direct heat or thermally conductive contact with one or more mounts (60, 50, 803) that are in turn mounted in direct heat conductive contact or communication with the manifold (20), the cooling device (500) comprising a heat transmitter comprised of an arm (502) comprised of a thermally conductive material having a distal end surface (502s) for making thermally conductive contact with the clamp plate (80), the proximal surface (502b) of the arm (502) being slidably engageable against a complementary surface (12ls) of the actuator that is spaced laterally (12ld) from the valve pin axis (A) for transmitting heat from the housing body (12) to the proximal surface (502b) and in turn to the dista

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.

Abstract: Provided are certain Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Provided are certain URAT1 inhibitors, pharmaceutical compositions thereof, and methods of use therefor.

Abstract: An evaporation source includes a crucible and a heater for generating heat radiation. The crucible includes a crucible body and a nozzle disposed on a top surface of the crucible body. Except for the top surface of the crucible body, at least one side of the remaining sides of the crucible body is provided with a heat adjusting assembly. The heat adjusting assembly is configured for convecting heat radiation between the heat adjusting assembly and the crucible body. A gap exists between the heat adjusting assembly and the crucible body.

Abstract: A method includes: sending a Real-time Transport Protocol data packet to a client; receiving a bandwidth value and a frame rate value fed back by the client, the bandwidth value and the frame rate value being calculated by parsing the data packet; obtaining a corresponding bandwidth weight according to the bandwidth value, and obtaining a corresponding frame rate weight according to the frame rate value; obtaining a quantization table weight according to the bandwidth weight and the frame rate weight; and matching image transmission data according to the quantization table weight; ands ending matched image data to the client.

Abstract: Apparatus and method for detecting a position of an actuator piston driving a valve pin in an injection molding system. The apparatus includes an actuator housing having a body portion, surrounding an axial bore, of a substantially non-magnetic and/or magnetically permeable material, a piston, movable within the axial bore for driving a valve pin, the piston including a magnetic member generating a magnetic field such that axial movement of the piston in the bore modifies the magnetic field according to the position of the piston relative to a detection position, and a magnetic field detector attached to an exterior surface of the body portion at the detection position for detecting the magnetic field associated with the position of the piston and generating an output signal determined by the piston position.

Abstract: An injection molding apparatus including an actuator interconnected to a rod or valve pin having a smooth continuous cylindrical outer surface and one or more discontinuous or relieved or relieved portions formed as discontinuities in the cylindrical outer surface and adapted to be disposed within a fluid flow channel, the one or more discontinuous or relieved portions being configured and arranged along the axial length of the pin or rod such that the flow of injection fluid over or past the one or more discontinuous or relieved portions is modified to flow at substantially different rates or velocities or in substantially different flow patterns relative to rate or velocity or pattern of flow of injection fluid over or past the smooth continuous cylindrical outer surface.

Abstract: Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof are provided. In particular, Bcl-2 inhibitors of formula (I) are provided, wherein the variable groups are as defined in the specification. The Bc1-2 inhibitors can be used to treat cell proliferative disorders.

Abstract: Embodiments of the present invention provide a method and system for timing related tasks in IoT systems, for example, in relation to synchronisation of clocks and timestamping. It is desirable that the method and system is able to withstand external tampering in a manner which does not jeopardise the accuracy and integrity of time related tasks in the IoT systems.

Abstract: Provided are certain CDK4/6 inhibitors with the structure of formula (I), pharmaceutical compositions thereof, and methods of use therefor. The compounds are of the class of pyrimidin-2 amine derivatives, useful for the treatment of hyper-proliferative diseases.

Abstract: An injection molding apparatus including: a valve pin driven by an actuator, the valve pin extending axially through at least a portion of the channel length of the fluid flow channel, the fluid flow channel and the valve pin being configured or adapted such that the valve pin is movable axially upstream and downstream between an upstream position where the downstream flow of the injection fluid is restricted by a bulbous protrusion (B) of the pin being axially aligned (AL) with the throat (T) of the channel, an intermediate position where downstream flow of injection fluid is unrestricted (WG) and a fully downstream position where downstream flow of injection fluid is stopped at both the gate and at the throat.

Abstract: An injection molding apparatus including: a valve pin driven by an actuator, the valve pin extending axially through at least a portion of the channel length of the fluid flow channel, the fluid flow channel including a throat, downstream flow of the injection fluid being restricted by a bulb portion of the pin, the valve pin having an intermediate position where downstream flow of injection fluid is unrestricted and a fully downstream position where downstream flow of injection fluid is stopped at both the gate and at the throat, wherein the actuator is driven by a valve assembly comprised of a spool mechanically driven by first and second actuators or solenoids that each separately engage the spool at opposing axial ends to effect movement of the spool back and forth between the drive fluid flow positions.

Abstract: Certain CDK4/6 inhibitors and pharmaceutically acceptable salts thereof are described. In particular, these compounds can inhibit kinase activity of CDK4/6 and may be useful for the treatment of hyper-proliferative diseases like cancer and inflammation. In addition, the pharmaceutical compositions thereof and methods of use thereof are also described.

Abstract: A packet data processing method, apparatus, and system. The method is executed by a first processing apparatus, and includes: acquiring packet data that needs to be processed, where the packet data that needs to be processed includes first packet data information and second packet data, and the first packet data information includes a header of the packet data that needs to be processed and a storage address of the packet data that needs to be processed in the first processing apparatus; sending the first packet data information to a second processing apparatus; and receiving first packet data information (includes an updated header after being processed and the storage address) processed by the second processing apparatus, and generating finished packet data using the first packet data information processed by the second processing apparatus and the second packet data.

Abstract: An injection molding apparatus comprising a heated manifold, an actuator comprised of an actuator housing containing a drive member interconnected to a valve pin having a drive axis, one or more heat convectors each heat convector comprised of a heat conductive leg disposed within a gap disposed between the manifold and a downstream end of the actuator housing and a heat conductive arm extending distally upstream and away from the gap such that heat is conducted from the leg to the arm upstream and away from the downstream end of the actuator housing.