Abstract: An apparatus and method for adjusting the axial position of a valve pin in an injection molding system, the apparatus comprising: an actuator comprising a housing having a chamber enclosing a drive member for driving a valve pin along an axial path of travel, the actuator housing slidably mounted and adapted for controlled upstream and downstream movement of the drive member along a path complementary to the axial path of travel of the valve pin, a mounting plate and an axial position adjustment screw screwably mounted within the mounting plate upstream of the housing of the actuator for controllably moving the valve pin to selectable starting or ending injection cycle axial positions.

Abstract: An injection molding apparatus including: a valve pin driven by an actuator, the valve pin extending axially through at least a portion of the channel length of the fluid flow channel, the fluid flow channel including a throat, downstream flow of the injection fluid being restricted by a bulb portion of the pin, the valve pin having an intermediate position where downstream flow of injection fluid is unrestricted and a fully downstream position where downstream flow of injection fluid is stopped at both the gate and at the throat, wherein the actuator is driven by a valve assembly comprised of a spool mechanically driven by first and second actuators or solenoids that each separately engage the spool at opposing axial ends to effect movement of the spool back and forth between the drive fluid flow positions.

Abstract: Provided are certain PI3K inhibitors, pharmaceutical compositions thereof, and methods of use therefor.

Abstract: An ultraviolet fluorescent barcode reading method and device, the reading method comprising the following steps: S1, irradiating an invisible ultraviolet fluorescent barcode via an ultraviolet light source and activating the invisible ultraviolet fluorescent barcode to be visible; S2, acquiring the image of the barcode activated to be visible; S3, filtering and decoding the barcode image to obtain corresponding barcode information; S4, outputting the barcode information. The reading method reads the invisible ultraviolet fluorescent barcode via a color filter, thus improving the convenience for reading.

Abstract: Apparatus and method for detecting a position of an actuator piston driving a valve pin in an injection molding system. The apparatus includes an actuator housing having a body portion, surrounding an axial bore, of a substantially non-magnetic and/or magnetically permeable material, a piston, movable within the axial bore for driving a valve pin, the piston including a magnetic member generating a magnetic field such that axial movement of the piston in the bore modifies the magnetic field according to the position of the piston relative to a detection position, and a magnetic field detector attached to an exterior surface of the body portion at the detection position for detecting the magnetic field associated with the position of the piston and generating an output signal determined by the piston position.

Abstract: An injection molding apparatus including: a valve pin driven by an actuator, the valve pin extending axially through at least a portion of the channel length of the fluid flow channel, the fluid flow channel including a throat, downstream flow of the injection fluid being restricted by a bulb portion of the pin, the valve pin having an intermediate position where downstream flow of injection fluid is unrestricted and a fully downstream position where downstream flow of injection fluid is stopped at both the gate and at the throat, wherein the actuator is driven by a valve assembly comprised of a spool mechanically driven by first and second actuators or solenoids that each separately engage the spool at opposing axial ends to effect movement of the spool back and forth between the drive fluid flow positions.

Abstract: An injection molding apparatus and method for adjusting the axial position of a valve pin in an injection molding system, the apparatus comprising: a top clamp plate, a heated manifold receiving and distributing an injection fluid to an exit of a fluid delivery channel to a cavity of the mold, an actuator comprising a housing having a chamber enclosing a drive member for driving a valve pin along an axial path of travel, the actuator housing slidably mounted and adapted for controlled upstream and downstream movement of the drive member along a path complementary to the axial path of travel of the valve pin, a mounting plate and an axial position adjustment screw screwably mounted within the mounting plate upstream of the housing of the actuator for controllably moving the valve pin to selectable starting or ending injection cycle axial positions.

Abstract: Apparatus and method for performing an injection molding cycle using the apparatus where the apparatus comprises: a manifold, a pneumatic actuator driven by a pneumatic valve assembly, the actuator driving a valve pin between a gate closed position and a maximum injection fluid flow position, the pneumatic valve assembly having a spool supported within a cylinder driven by a drive device that is supported solely by and translates together with the spool, a controller that instructs the pneumatic valve assembly to cause the actuator to drive the valve pin either upstream or downstream to selected positions or at selected velocities during the course of a single injection cycle based on a feedback signal indicative of position of the pin or actuator or pressure of an injection fluid material.

Abstract: An injection molding apparatus comprising a heated manifold, an actuator comprised of an actuator housing containing a drive member interconnected to a valve pin having a drive axis, one or more heat convectors each heat convector comprised of a heat conductive leg disposed within a gap disposed between the manifold and a downstream end of the actuator housing and a heat conductive arm extending distally upstream and away from the gap such that heat is conducted from the leg to the arm upstream and away from the downstream end of the actuator housing.

Abstract: An injection molding apparatus comprising: a pneumatically driven actuator having a piston mounted within a fluid sealed chamber for slidable axial movement along or against an interior surface of the fluid sealed chamber via a non-elastomeric engagement or with a non-elastomeric material disposed between the piston and the interior surface of the fluid sealed chamber, the piston forming first and second drive chambers within the fluid sealed chamber, each drive chamber having respective fluid flow ports, a source of pressurized gas that generates gas flow at a selected maximum pressure or flow rate, a gas metering mechanism, a controller interconnected to the gas metering mechanism, the controller controllably moving the gas metering mechanism to selectable positions that correspond to reduced pressures or reduced flow rates during the course of pin travel from the fully downstream gate closed position to the fully upstream gate open position.

Abstract: Apparatus and method for performing an injection molding cycle using the apparatus where the apparatus comprises: a manifold, a pneumatic actuator driven by a pneumatic valve assembly, the actuator driving a valve pin between a gate closed position and a maximum injection fluid flow position, the pneumatic valve assembly having a spool supported within a cylinder driven by a drive device that is supported solely by and translates together with the spool, a controller that instructs the pneumatic valve assembly to cause the actuator to drive the valve pin either upstream or downstream to selected positions or at selected velocities during the course of a single injection cycle based on a feedback signal indicative of position of the pin or actuator or pressure of an injection fluid material.

Abstract: An injection molding apparatus (10) comprising: a heated manifold (16), one or more fluid driven actuators (210a, 210b) each interconnected to a corresponding valve pin (211a, 211b), a housing comprised of one or more metal plates (202a, 202b, 204a, 204b, 206) arranged to form a manifold chamber (208), each of the fluid driven actuators (210a, 210b) being mounted within or at least about one foot from within the manifold chamber (208), each fluid driven actuator being fluid drive interconnected to a proportional control valve (213a, 213b, 213c) that is mounted either within the manifold chamber (208) or having fluid flow ports (213p1, 213p2) that are interconnected within about one foot of corresponding fluid flow ports (210p1, 210p2) of a corresponding fluid driven actuator (210a, 210b).

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.

Abstract: An injection molding apparatus comprising a heated manifold, an actuator comprised of an actuator housing containing a drive member interconnected to a valve pin having a drive axis, one or more heat convectors each heat convector comprised of a heat conductive leg disposed within a gap disposed between the manifold and a downstream end of the actuator housing and a heat conductive arm extending distally upstream and away from the gap such that heat is conducted from the leg to the arm upstream and away from the downstream end of the actuator housing.

Abstract: An injection molding apparatus comprising: a pneumatically driven actuator having a piston mounted within a fluid sealed chamber for slidable axial movement along or against an interior surface of the fluid sealed chamber via a non-elastomeric engagement or with a non-elastomeric material disposed between the piston and the interior surface of the fluid sealed chamber, the piston forming first and second drive chambers within the fluid sealed chamber, each drive chamber having respective fluid flow ports, a source of pressurized gas that generates gas flow at a selected maximum pressure or flow rate, a gas metering mechanism, a controller interconnected to the gas metering mechanism, the controller controllably moving the gas metering mechanism to selectable positions that correspond to reduced pressures or reduced flow rates during the course of pin travel from the fully downstream gate closed position to the fully upstream gate open position.

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.

Abstract: An ultraviolet fluorescent barcode reading method and device, the reading method comprising the following steps: S1, irradiating an invisible ultraviolet fluorescent barcode via an ultraviolet light source and activating the invisible ultraviolet fluorescent barcode to be visible; S2, acquiring the image of the barcode activated to be visible; S3, filtering and decoding the barcode image to obtain corresponding barcode information; S4, outputting the barcode information. The reading method reads the invisible ultraviolet fluorescent barcode via a color filter, thus improving the convenience for reading.

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.

Abstract: An injection molding apparatus including an actuator interconnected to a rod or valve pin having a smooth continuous cylindrical outer surface and one or more discontinuous or relieved or relieved portions formed as discontinuities in the cylindrical outer surface and adapted to be disposed within a fluid flow channel, the one or more discontinuous or relieved portions being configured and arranged along the axial length of the pin or rod such that the flow of injection fluid over or past the one or more discontinuous or relieved portions is modified to flow at substantially different rates or velocities or in substantially different flow patterns relative to rate or velocity or pattern of flow of injection fluid over or past the smooth continuous cylindrical outer surface.

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.