Patents by Inventor Ruoxi Lan

Ruoxi Lan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
    Patent number: 9815836
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: November 14, 2017
    Assignee: Merck Patent GmbH
    Inventors: Xiaoling Chen, Henry Yu, Ruoxi Lan, Catherine Jorand-Lebrun, Theresa L. Johnson, Andreas Goutopoulos
  • Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
    Publication number: 20170275284
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: June 12, 2017
    Publication date: September 28, 2017
    Inventors: Xiaoling CHEN, Henry YU, Ruoxi LAN, Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20170217905
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: April 18, 2017
    Publication date: August 3, 2017
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Lizbeth C. DESELM, Hui QIU, Yufang XIAO, Constantin NEAGU, Igor MOCHALKIN, Theresa L. JOHNSON
  • Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
    Patent number: 9708324
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 18, 2017
    Assignee: Merck Patent GmbH
    Inventors: Xiaoling Chen, Henry Yu, Ruoxi Lan, Catherine Jorand-Lebrun, Theresa L. Johnson, Andreas Goutopoulos
  • PYRIDAZINONE MACROCYCLES AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20170173019
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: March 6, 2017
    Publication date: June 22, 2017
    Inventors: Xiaoling CHEN, Ruoxi LAN, Catherine JORAND-LEBRUN, Henry YU, Andreas GOUTOPOULOS
  • Aminopyrimidine derivatives for use as modulators of kinase activity
    Patent number: 9662330
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: May 30, 2017
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Lizbeth C. Deselm, Hui Qiu, Yufang Xiao, Constantin Neagu, Igor Mochalkin, Theresa L. Johnson
  • Pyridazinone macrocycles as IRAK inhibitors and uses thereof
    Patent number: 9624246
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: April 18, 2017
    Assignee: Merck Patent GmbH
    Inventors: Xiaoling Chen, Ruoxi Lan, Catherine Jorand-Lebrun, Henry Yu, Andreas Goutopoulos
  • HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20170081317
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 23, 2017
    Inventors: Catherine JORAND-LEBRUN, Ruoxi LAN, Austin CHEN, Ryan C. Clark
  • HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20170081307
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 23, 2017
    Inventors: Catherine JORAND-LEBRUN, Ruoxi LAN, Austin CHEN, Ryan C. CLARK
  • Heterocyclic derivatives as modulators of kinase activity
    Patent number: 9580443
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: February 28, 2017
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao
  • Novel Heterocyclic Derivatives as Modulators of Kinase Activity
    Publication number: 20170015679
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 27, 2016
    Publication date: January 19, 2017
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO
  • NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160361316
    Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 15, 2016
    Inventors: Ruoxi LAN, Xiaoling CHEN, Yufang XIAO, Bayard R. HUCK, Andreas GOUTOPOULOS
  • NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160339028
    Abstract: The invention provides novel heterocyclic carboxamide compounds compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO, Ruoxi LAN, Lizbeth Celeste DE SELM, Constantin NEAGU, Justin POTNICK, Srinivasa R. KARRA, Theresa L. JOHNSON
  • AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES
    Publication number: 20160340323
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Bayard R. HUCK, Ruoxi LAN, Justin POTNICK, Lizbeth Celeste DESELM, Mark W. CRONIN, JR., Constantin NEAGU, Xiaoling CHEN, Roch BOIVIN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • Heterocycles as modulators of kinase activity
    Patent number: 9458134
    Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 4, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R. Huck, Andreas Goutopoulos
  • Substituted pyrido[3,2-d]pyrimidines for treating cancer
    Patent number: 9440968
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 13, 2016
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Ruoxi Lan, Justin Potnick, Lizbeth Celeste Deselm, Mark W. Cronin, Jr., Constantin Neagu, Xiaoling Chen, Roch Boivin, Theresa L. Johnson, Andreas Goutopoulos
  • Pyrimidine imidazole amines as modulators of kinase activity
    Patent number: 9434714
    Abstract: The invention provides novel imidazole amine compounds according to formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: September 6, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R. Huck, Andreas Goutopoulos
  • PYRIDAZINONE MACROCYCLES AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160229871
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 11, 2016
    Inventors: Xiaoling CHEN, Ruoxi LAN, Catherine JORAND-LEBRUN, Henry YU, Andreas GOUTOPOULOS
  • Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
    Publication number: 20160229856
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 11, 2016
    Inventors: Xiaoling CHEN, Henry YU, Ruoxi LAN, Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
    Patent number: 9409945
    Abstract: A library of macrocyclic compounds of the formula (I) where part (A) is a ?bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a ?bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a ?bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; and where part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: August 9, 2016
    Assignee: Ocera Therapeutics, Inc.
    Inventors: Pierre Deslongchamps, Yves Dory, Gilles Berthiaume, Luc Ouellet, Ruoxi Lan