Patents by Inventor Ruoxi Lan

Ruoxi Lan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160184308
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: March 3, 2016
    Publication date: June 30, 2016
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Lizbeth C. DESELM, Hui QIU, Yufang XIAO, Constantin NEAGU, Igor MOCHALKIN, Theresa L. JOHNSON
  • Aminopyrimidine derivatives for use as modulators of kinase activity
    Patent number: 9321760
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: April 26, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Lizbeth Celeste Deselm, Hui Qiu, Yufang Xiao, Constantin Neagu, Igor Mochalkin, Theresa L. Johnson
  • Imidazol-piperidinyl derivatives as modulators of kinase activity
    Patent number: 9315517
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of formula (I) in which R1, R2, X1, X2, X3, X4 and n have the meanings indicated in above, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: April 19, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao
  • NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160058763
    Abstract: The invention provides novel heterocyclic carboxamide compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 8, 2015
    Publication date: March 3, 2016
    Inventors: Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO, Ruoxi LAN, Lizbeth Celeste DE SELM, Constantin NEAGU, Justin POTNICK, Srinivasa R. KARRA, Theresa L. JOHNSON
  • NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160016936
    Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: March 10, 2014
    Publication date: January 21, 2016
    Applicant: Merck Patent GmbH
    Inventors: Ruoxi LAN, Xiaoling CHEN, Yufang XIAO, Bayard R. HUCK, Andreas GOUTOPOULOS
  • Novel Imidazole Amines as Modulators of Kinase Activity
    Publication number: 20160000785
    Abstract: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO, Lizbeth Celeste DESELM, Hui QIU, Constantin NEAGU, Donald BANKSTON, Christopher Charles Victor JONES
  • Combinatorial Synthesis of Libraries of Macrocyclic Compounds Useful in Drug Discovery
    Publication number: 20150315235
    Abstract: A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; and where part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.
    Type: Application
    Filed: April 27, 2015
    Publication date: November 5, 2015
    Inventors: Pierre Deslongchamps, Yves Dory, Gilles Berthiaume, Luc Ouellet, Ruoxi Lan
  • Novel Heterocyclic Derivatives as Modulators of Kinase Activity
    Publication number: 20150274750
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: November 15, 2013
    Publication date: October 1, 2015
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao
  • Imidazole amines as modulators of kinase activity
    Patent number: 9145392
    Abstract: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: September 29, 2015
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Yufang Xiao, Xiaoling Chen, Lizbeth Celeste Deselm, Hui Qiu, Constantin Neagu, Donald Bankston, Christopher Charles Victor Jones
  • Heterocyclic carboxamides as modulators of kinase activity
    Patent number: 9139568
    Abstract: The invention provides novel heterocyclic carboxamide compounds according to Formula (I), their manufacture, and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: September 22, 2015
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Xiaoling Chen, Yufang Xiao, Ruoxi Lan, Lizbeth Celeste De Selm, Constantin Neagu, Justin Potnick, Srinivasa R. Karra, Theresa L. Johnson
  • AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES
    Publication number: 20150259339
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Application
    Filed: November 27, 2013
    Publication date: September 17, 2015
    Inventors: Bayard R. Huck, Ruoxi Lan, Justin Potnick, Lizbeth Celeste Deselm, Mark W. Cronin, JR., Constantin Neagu, Xiaoling Chen, Roch Boivin, Theresa L. Johnson, Andreas Goutopoulos
  • Novel Imidazol-piperidinyl Derivatives as Modulators of Kinase Activity
    Publication number: 20150239902
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of formula (I) in which R1, R2, X1, X2, X3, X4 and n have the meanings indicated in above, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: November 15, 2013
    Publication date: August 27, 2015
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao
  • Novel Pyrimidine Imidazole Amines as Modulators of Kinase Activity
    Publication number: 20150225371
    Abstract: The invention provides novel imidazole amine compounds according to formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: February 10, 2015
    Publication date: August 13, 2015
    Inventors: Ruoxi LAN, Xiaoling CHEN, Yufang XIAO, Bayard R. HUCK, Andreas GOUTOPOULOS
  • Amino azaheterocyclic carboxamides
    Patent number: 9040560
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: May 26, 2015
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Thomas E. Richardson, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Yufang Xiao, Andreas Goutopoulos, Ruoxi Lan, David Perrey, Harold George Vandeveer, Lesley Liu-Bujalski, Frank Stieber, Brian L. Hodous, Hui Qiu, Reinaldo C. Jones, Brian H. Heasley
  • AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20150126484
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 12, 2012
    Publication date: May 7, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Lizbeth Celeste Deselm, Yufang Xiao, Hui Qiu, Constantin Neagu, Igor Mochalkin, Theresa L. Johnson
  • Azaheterocyclic compounds
    Patent number: 9023847
    Abstract: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Nadia Brugger, Thomas E. Richardson, Harold George Vandeveer, Bayard R. Huck, Ruoxi Lan, Justin Potnick
  • Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
    Patent number: 9018419
    Abstract: A library of macrocyclic compounds of the formula (I) where part (A) is a ?bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a ?bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a ?bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; and where part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 28, 2015
    Assignee: Ocera Therapeutics, Inc.
    Inventors: Pierre Deslongchamps, Yves Dory, Gilles Berthiaume, Luc Ouellet, Ruoxi Lan
  • Novel Imidazole Amines as Modulators of Kinase Activity
    Publication number: 20140343029
    Abstract: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 12, 2012
    Publication date: November 20, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao, Lizbeth Celeste Deselm, Hui Qiu, Constantin Neagu, Donald Bankston, Christopher Charles Victor Jones
  • Novel Heterocyclic Carboxamides as Modulators of Kinase Activity
    Publication number: 20140309245
    Abstract: The invention provides novel heterocyclic carboxamide compounds compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: December 17, 2012
    Publication date: October 16, 2014
    Inventors: Bayard R. Huck, Xiaoling Chen, Yufang Xiao, Ruoxi Lan, Lizbeth Celeste De Selm, Constantin Neagu, Justin Potnick, Srinivasa R. Karra, Theresa L. Johnson
  • Bicyclic azaheterocyclic carboxamides
    Patent number: 8710044
    Abstract: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 29, 2014
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Constantin Neagu, Reinaldo Jones, Lizbeth Celeste DeSelm, Yufang Xiao, Srinivasa R. Karra, Ruoxi Lan, Igor Mochalkin, Amanda E. Sutton, Thomas E. Richardson