Abstract: A vascular closure system includes a swellable/bioabsorbable tubular sealing element and a tubular advancement/deployment tool. The sealing element and advancement tool is configured to be attached to the outside of a tubular medical device (such as a vascular introducer, catheter, cannula, trocar, electrode wire, etc.) with the sealing element being advanced distally to a desired area within the body (near or at least partially within an arteriotomy, for example) by the advancement/deployment tool. Once in contact with blood (or other fluid) the sealing element swells, sealing the passageway. The system may include one of several different means to prevent insertion (or over insertion) into the vessel. Additional versions of the system described herein can be used for cardiovascular applications where hemostasis (temporary or permanent) is desired.

Abstract: A catheter is insertable into a vessel within a mammalian body. The catheter includes a tubular body, at least one channel extending along the tubular body; and a central lumen. The tubular body includes an exterior surface, a first end and a second end, and defines a length between the first end and the second end. The channel passes between a first opening and a second opening and includes a slot in the tubular body between the channel and the exterior surface of the tubular body such that a tubular member can be passed between the channel and the exterior surface. The slot extends from the first opening to the second opening and includes a pair of edges. The central lumen extends along the tubular body at least for a portion of the length of the tubular body.

Abstract: A surgical instrument is used for temporary use in a medical procedure in a mammalian body. The surgical instrument is configured to be changed between two shapes upon application of one or both of heating and cooling. The instrument includes a first member, a second member having a surface configured to contact tissue, and a means to apply heating or cooling to one or both of the first member and the second member to change the shape between a first shape and a second shape. A surgical instrument also may be configured to be changed between two shapes upon removal of a constraining force. The surgical instrument includes a first member, a second member having a surface configured to contact tissue, and a constraining means to apply a constraining force to one or both of the first member and the second member to cause one or both of the first member and the second member to be in a first constrained shape. The surgical instruments may be used in minimally invasive valve surgery.

Abstract: A coupler is configured to connect a first tubular vessel to an aperture in a second tubular vessel. The coupler includes one or more radially extending members and a substantially nonmetallic tubular member. The substantially nonmetallic tubular member include an outer wall, an inner wall defining a lumen having an open distal end and an open proximal end, and a circumferential ridge encircling the outer wall, the radially extending members extending from the distal end of the tubular member. A method of fabricating a coupler the method including fabricating radially extending members; placing the radially extending members within a mold; injecting a material into the mold; allowing the material to cure to form the c coupler; and removing the coupler from the mold. The coupler includes a tubular member having an outer wall, an inner wall defining a lumen having an open distal end and an open proximal end, and a circumferential ridge encircling the outer wall.

Abstract: Apparatus and methods are provided for thermally and/or mechanically treating tissue, such as valvular structures, to reconfigure or shrink the tissue in a controlled manner. The apparatus comprises a catheter in communication with an end effector which induces a temperature rise in an annulus of tissue surrounding the leaflets of a valve or in the chordae tendineae sufficient to cause shrinkage, thereby causing the valves to close more tightly. Mechanical clips can also be implanted over the valve either alone or after the thermal treatment. The clips are delivered by a catheter and may be configured to traverse directly over the valve itself or to lie partially over the periphery of the valve to prevent obstruction of the valve channel. The clips can be coated with drugs or a radiopaque coating. The catheter can also incorporate sensors or energy delivery devices, e.g., transducers, on its distal end.

Abstract: A catheter is insertable into a vessel within a mammalian body. The catheter includes a tubular body, at least one channel extending along the tubular body, and a central lumen. The tubular body includes an exterior surface, a first end and a second end, and defines a length between the first end and the second end. The channel passes between a first opening and a second opening and includes a slot in the tubular body between the channel and the exterior surface of the tubular body such that a tubular member can be passed between the channel and the exterior surface. The slot extends from the first opening to the second opening and includes a pair of edges. The central lumen extends along the tubular body at least for a portion of the length of the tubular body.

Abstract: A tissue heating instrument includes a device with a window at its distal end for admitting tissue against or into a compartment within the device. A cylindrical cartridge in the compartment includes a heating surface that supports an electrically conductive heating element, e.g. a band or wire. The tissue adjacent to the heating element can be heated to a selected temperature by generating an electrical current through the heating element. The device is maneuverable to position its distal end near the tissue to be treated. The device also incorporates a vacuum feature that urges tissue into the compartment prior to heating and assists in holding the tissue during the heating process. The device incorporates a dilatation balloon or other feature to urge the device against the tissue, so that at least part of the tissue may come in contact with, or enter the compartment through the window.

Abstract: Apparatus and methods are provided for thermally and/or mechanically treating tissue, such as valvular structures, to reconfigure or shrink the tissue in a controlled manner. The apparatus comprises a catheter in communication with an end effector which induces a temperature rise in an annulus of tissue surrounding the leaflets of a valve or in the chordae tendineae sufficient to cause shrinkage, thereby causing the valves to close more tightly. Mechanical clips can also be implanted over the valve either alone or after the thermal treatment. The clips are delivered by a catheter and may be configured to traverse directly over the valve itself or to lie partially over the periphery of the valve to prevent obstruction of the valve channel. The clips can be coated with drugs or a radiopaque coating. The catheter can also incorporate sensors or energy delivery devices, e.g., transducers, on its distal end.

Abstract: A coupler is configured to connect a first tubular vessel to an aperture in a second tubular vessel. The coupler includes one or more radially extending members and a substantially nonmetallic tubular member. The substantially nonmetallic tubular member include an outer wall, an inner wall defining a lumen having an open distal end and an open proximal end, and a circumferential ridge encircling the outer wall, the radially extending members extending from the distal end of the tubular member. A method of fabricating a coupler the method including fabricating radially extending members; placing the radially extending members within a mold; injecting a material into the mold; allowing the material to cure to form the coupler; and removing the coupler from the mold. The coupler includes a tubular member having an outer wall, an inner wall defining a lumen having an open distal end and an open proximal end, and a circumferential ridge encircling the outer wall.

Abstract: The invention is directed to a method of fabricating an artificial limb. The method includes the steps of: cutting one or more superelastic materials to a desired length, forming the superelastic material into a desired resting configuration of an artificial limb using a fixture that includes the desired resting configuration, heating the superelastic material to between 300 degrees Celsius and 750 degrees Celsius, cooling the superelastic material, and removing the superelastic material from the fixture.

Abstract: A tissue cutting device includes a catheter with a window at its distal tip for admitting tissue into a catheter compartment. A cylindrical cartridge in the compartment has a cutting edge that supports an electrically conductive cutting element, e.g. a band or wire. The cutting element and adjacent tissue can be heated to a selected temperature by generating an electrical current through the cutting element. The catheter is maneuverable to position its distal end near the tissue to be cut. The catheter incorporates a dilatation balloon or other feature to urge the catheter against the tissue, so that at least part of the tissue may enter the compartment through the window. Then, the cartridge is manipulated from the catheter's proximal end to move the cutting edge across the window, cutting the tissue. According to alternative embodiments, the cartridge is either rotated or moved axially relative to the catheter and, in either event may be capable of closing the catheter window when the cut is complete.

Abstract: A bypass graft incorporates fixation mechanisms at its opposite ends, for securing these ends to different locations along a blood vessel, or alternatively to different locations wherein one of the locations is a different vessel or an organ defining a cavity. Mechanical fixation features such as collets or grommets can be employed, enhanced by delivery of an electrical current sufficient to heat surrounding tissue to form a thermal bond. A graft deployment system includes a tissue dilator and a needle for perforating tissue, mounted coaxially within the dilator. Intralumenal systems further include a catheter for containing the dilator.

Abstract: An arterial closure system includes an arterial closure device (“ACD”) and a deployment tool. The arterial closure device includes a first member forming an enlargement around the circumference of the arterial closure device and being configured to be received against an outer surface of a vessel, a connecting member having a smaller outer diameter than the first member, extending from the first member, and being configured to be positioned within an arteriotomy of a vessel, and a longitudinal channel configured to receive a tube and passing between the first member and the connecting member. The deployment tool includes a handle, a contacting section, and an extension that extends between the handle and the contacting section. The contacting section is designed to mate with the arterial closure device to advance the arterial closure device over the tube and deploy the arterial closure device within the vessel.

Abstract: A stent apparatus and its use is provided comprising a substantially tubular member with an inside surface and an outside surface; and a securing element for securing the tubular member to the exterior of a body lumen. The method for implanting the stent to the exterior of a body lumen comprises providing for an exterior stent, inserting the stent around a desired location on the exterior of the lumen, and providing for controlled expansion of the lumen such that it contacts the stent sufficiently to secure it to the lumen.

Abstract: Percutaneous transmyocardial revascularizaton systems are disclosed for creating thin, linear incisions through the endocardium and partially into the myocardium. The systems mitigate the deficiencies of current approaches that position a distal tip channeling mechanism against the endocardial surface. The systems position a catheter body lengthwise along the endocardial surface and incorporate a cutting mechanism movable radially relative to the catheter body to create one or more elongate thin, linear incisions along one or more windows through the catheter body. Flexible support strands are used to urge each window into intimate contact with the endocardial surface. Each cutting element is adapted to protrude radially outward from the catheter body to contact tissue adjacent each window. The cutting mechanism incorporates a mechanical cutting element or an electrode designed to transmit direct current or radiofrequency energy into tissue to simultaneously cut and coagulate tissue.

Abstract: A racket includes a handle section, a head section, and a connecting section positioned between the handle section and the head section. One or more of the handle section, the head section, and the connecting section include a superelastic metal. The racket, other athletic devices and other devices containing superelastic components are capable of producing a spring force in response to a deflection. The superelastic components may improve the performance of rackets, athletic devices and other devices by increasing the contact duration between the active element of the device and objects against which the devices are configured to exert a force. The superelastic components also provide increased resistance to breakage or plastic deformation of the racket, athletic device or other devices, especially when exposed to frequent deflections. Superelastic components are able to decrease the weight of rackets, athletic devices, or other devices without sacrificing strength.

Abstract: A kit and method are described for treating congestive heart failure. The kit may comprise multiple components including a shaping device, deployment tool, patch, and suture. The method may utilize one or more of these components.

Abstract: A kit and method are described for treating congestive heart failure. The kit may comprise multiple components including a shaping device, deployment tool, patch, and suture. The method may utilize one or more of these components.

Abstract: This is a support device that prevents, reduces, and delays remodeling of diseased cardiac tissue, and also decreases the impact of such remodeling on collateral tissue is disclosed. The invention further reinforces abnormal tissue regions to prevent over-expansion of the tissue due to increased afterload and excessive wall tension. As a result, the support device prevents phenomenon such as systolic stretch from occurring and propagating. The support structure maintains and restores diastolic compliance, wall motion, and ejection fraction to preserve heart functionality. As such, the support device prevents and treats cardiomyopathy and congestive heart failure.

Abstract: A kit and method are described for treating congestive heart failure. The kit may comprise multiple components including a shaping device, deployment tool, patch, and suture. The method may utilize one or more of these components.