Abstract: A bypass graft incorporates fixation mechanisms at its opposite ends, for securing these ends to different locations along a blood vessel, or alternatively to different locations wherein one of the locations is a different vessel or an organ defining a cavity. Mechanical fixation features such as collets or grommets can be employed, enhanced by delivery of an electrical current sufficient to heat surrounding tissue to form a thermal bond. A graft deployment system includes a tissue dilator and a needle for perforating tissue, mounted coaxially within the dilator. Intralumenal systems further include a catheter for containing the dilator.

Abstract: A multiple electrode array for ablating tissue carries at least two electrode segments that are circumferentially spaced from each other. Insulation electrically isolates the separated electrode segments from each other. Signal wires attached to the separated electrode segments convey ablating energy independently to the separated electrode segments. Because of its segmented structure, the array can place only one of the electrode segments in contact with tissue at one time. Because each segment is electrically isolated, and because each segment is independently served by its own signal wire, a physician can operate an ablation energy generator to selectively channel the ablation energy only to the segment actually contacting the tissue.

Abstract: A deployment device for stents and grafts includes a catheter, an expansion framework or cage near the catheter distal end, and a means for controlling expansion from a proximal end of the catheter. The cage is formed of a plurality of elongate strands coupled at opposite ends to the catheter and to the control device. Axial movement of the control device relative to the catheter either elongates the strands to radially collapse the cage, or axially reduces the distance between the strand ends for radial enlargement. In one embodiment the control device is a stylet contained in a lumen of the catheter and extending beyond the catheter distal end. The strands are fixed at their opposite ends to the catheter distal end and the stylet distal end. In another embodiment, the strands are coupled to proximal and distal rings along the catheter, with one of the rings being axially movable by a wire to radially expand and reduce the cage.

Abstract: A resilient graft construction incorporates a structural layer formed of a resilient body compatible metal or polymer, and a fluid impervious layer of graft material secured to the structural layer. The structural layer includes an elongate longitudinal primary section, and secondary sections extended transversely from opposite sides of the primary section. The secondary sections can be arranged in opposed pairs, or staggered. The secondary sections further can be tapered in width, thickness or both. The grafts can be constructed by stamping or otherwise severing structural layer patterns from a flat sheet of structural material, then thermally setting the structural layers when they are wrapped about a mandril to determine a relaxed-state curvature. Opposed longitudinal edges either can overlap one another or be spaced apart from one another in the relaxed state. According to one alternative, the structural layer alone functions as a stent.

Abstract: An electrode tip assembly attachable to the end of a catheter for supporting a tip electrode for percutaneous insertion into a living body having a steering mechanism includes an elongated body bendable in response to external forces to steer the tip electrode. The body is connected at its distal end to the tip electrode. At least one steering wire is attached to the elongated body for transmitting bending force to the body from a remote control mechanism. An movable stiffening member, preferably in the form of a sleeve or rod provides a variable fulcrum for bending of the body in response to an applied bending force. A control stylet or sleeve extends through the catheter and is attached to the stiffening member for moving the stiffening member in a distal/proximal direction or for rotating it relative to the body.

Abstract: A method of bonding sections of a catheter body together in abutting relationship including the steps of providing a temperature resistance polymeric sleeve, which sleeve preferably has a spirally wound metallic wire imbedded between its inner and outer diameters. The sleeve is inserted into ends of tubing segments to be joined together to form a catheter body. Then heat is applied over the area including the sleeve to melt the tubing over the sleeve.

Abstract: A bypass graft incorporates fixation mechanisms at its opposite ends, for securing these ends to different locations along a blood vessel, or alternatively to different locations wherein one of the locations is a different vessel or an organ defining a cavity. Mechanical fixation features such as collets or grommets can be employed, enhanced by delivery of an electrical current sufficient to heat surrounding tissue to form a thermal bond. A graft deployment system includes a tissue dilator and a needle for perforating tissue, mounted coaxially within the dilator. Intralumenal systems further include a catheter for containing the dilator.

Abstract: An electrode tip assembly attachable to the end of a catheter for supporting a tip electrode for percutaneous insertion into a living body having a steering mechanism includes an elongated body bendable in response to external forces to steer the tip electrode. The body is connected at its distal end to the tip electrode. At least one steering wire is attached to the elongated body for transmitting bending force to the body from a remote control mechanism. An movable stiffening member, preferably in the form of a sleeve or rod provides a variable fulcrum for bending of the body in response to an applied bending force. A control stylet or sleeve extends through the catheter and is attached to the stiffening member for moving the stiffening member in a distal/proximal direction or for rotating it relative to the body.

Abstract: An electrode tip assembly attachable to the end of a catheter for supporting a tip electrode for percutaneous insertion into a living body having a steering mechanism includes an elongated body bendable in response to external forces to steer the tip electrode. The body is connected at its distal end to the tip electrode. At least one steering wire is attached to the elongated body for transmitting bending force to the body from a remote control mechanism. An movable stiffening member, preferably in the form of a sleeve or rod provides a variable fulcrum for bending of the body in response to an applied bending force. A control stylet or sleeve extends through the catheter and is attached to the stiffening member for moving the stiffening member in a distal/proximal direction or for rotating it relative to the body.

Abstract: A catheter having a proximal portion and a distal portion terminating in a distal tip, is provided with a spring assembly contained within its distal tip portion for providing a bias against side to side deflection of the distal tip. The assembly preferably includes a central wire having a first diameter, which central wire extends from the proximal portion of the catheter to the distal portion, and a plurality of wires secured to the central wire adjacent the distal end thereof. Each of the wires is stranded together, preferably twisted helically, around the central wire and preferably has a second diameter substantially smaller than the first diameter. Alternatively, the stranded wires can be attached along and parallel to the larger diameter wire, and the latter wire is of a substantially greater length than the stranded wires.

Abstract: A device for ablating tissue within the body has an element with an energy emitting region helically wound about and along the axis of the element. The element emits energy to create a lesion in body tissue. A sheath of a non-energy emitting material is movable over the region to adjust the impedance of the region.

Abstract: A balloon catheter includes an elongate pliable catheter tubing with a dilatation balloon fixed to the catheter tubing near its distal end. The dilatation balloon includes a first wall for dividing the balloon into a plurality of dilatation compartments adjacent one another and arranged angularly about the catheter tubing. Each dilatation compartment is fluid tight and in fluid isolation from other compartments. The compartments are individually controlled so the pressure within each balloon compartment may be adjusted as determined by the operator. The dilatation balloon includes a second wall composed of the respective outer wall portions of the dilatation compartments which defines an outer transverse profile of the dilatation balloon and adapted to form surface engagement with the tissue segments surrounding the balloon when the compartments are dilatated.

Abstract: Systems and methods sense electrical events about a selected annulus region of the heart to identify the location of an accessory pathway. The systems and methods establish a contact site between heart tissue along the selected annulus and a multi-electrode array having a generally circular shape that conforms to the circumferential geometry of the selected annulus region. The systems and methods maintain the site of contact between the electrode array and heart tissue, while conveying signals representing electrical events sensed by bipolar pairs of the electrodes in the selected annulus region, The systems and methods display the signals as graphic information that represents the time differences between the atrial and ventricular electrogram complexes sensed by bipolar pairs of the electrodes on the selected annulus region. The bipolar pair of electrodes displaying the least time separation between the atrial and ventricular complexes identifies the region of the accessory pathway.

Abstract: A catheter having an elongated polymeric body with hollow encircling ring electrodes thereon and a method of forming the same are provided by the invention. Ring electrodes are each connected to an external electrical circuit by wires extending through the lumen, the wires each passing through an aperture through a wall of the body and being connected to an interior surface of the ring electrode. The tubular body of the catheter is expanded into a tight interference fit with the interior surfaces of the ring electrodes by heating the body to a temperature approaching its glass transition temperature to permit relief of internal stresses.

Abstract: A catheter supporting a tip electrode for percutaneous insertion into a living body having a steering mechanism that includes an elongated body bendable in response to external forces to steer the tip electrode. An axially movable stiffening member, preferably in the form of a sleeve or rod provides a variable resistance to bending of the body in response to an applied bending force. A control stylet or sleeve extends through the catheter and is attached to the stiffening member for moving the stiffening member in a distal/proximal direction relative to the body.

Abstract: Systems and methods sense electrical events about a selected annulus region of the heart to identify the location of an accessory pathway. The systems and methods establish a contact site between heart tissue along the selected annulus and a multi-electrode array having a generally circular shape that conforms to the circumferential geometry of the selected annulus region. The systems and methods maintain the site of contact between the electrode array and heart tissue, while conveying signals representing electrical events sensed by bipolar pairs of the electrodes in the selected annulus region. The systems and methods display the signals as graphic information that represents the time differences between the atrial and ventricular electrogram complexes sensed by bipolar pairs of the electrodes on the selected annulus region. The bipolar pair of electrodes displaying the least time separation between the atrial and ventricular complexes identifies the region of the accessory pathway.

Abstract: An atherectomy device includes a catheter with a window at its distal tip for admitting tissue into a catheter compartment. A cylindrical cartridge in the compartment has a cutting edge that supports an electrically conductive cutting element, e.g. a band or wire. The cutting element and adjacent tissue can be heated to a selected temperature by generating an electrical current through the cutting element. The catheter is maneuverable to position its distal end near a lesion in an artery. The catheter incorporates a dilatation balloon or other feature to urge the catheter against the lesion, so that at least part of the lesion enters the compartment through the window. Then, the cartridge is manipulated from the catheter's proximal end to move the cutting edge across the window, severing the acquired tissue. According to alternative embodiments, the cartridge is either rotated or moved axially relative to the catheter, in either event closing the catheter window when the cut is complete.

Abstract: Systems and methods sense electrical events in heart tissue to identify the location of an arrhythmogenic focus for ablation. The systems and methods establish a contact site between heart tissue and a curvilinear electrode array. The systems and methods monitor signals representing electrical events sensed by the electrodes in the contact site. The signals are displayed as graphic information that represents the time sequence in which the electrodes sense a given electrical event. By moving the electrode array to one or additional contact sites in the general direction of the electrode that first sensed the electrical event, the physician homes in on a contact site in which all electrodes on the array sense the given electrical event at generally the same time. This contact site contains the arrhythmogenic focus. The systems and methods convey ablating energy to bipolar pairs of the electrodes to form large bipolar lesions in heart tissue.

Abstract: A catheter having a proximal portion and a distal portion terminating in a distal tip, is provided with a spring assembly contained within its distal tip portion for providing a bias against side to side deflection of said distal tip. The assembly preferably includes a central wire having a first diameter, which central wire extends from the proximal portion of the catheter to the distal portion, and a plurality of wires secured to the central wire adjacent the distal end thereof. Each of the wires is stranded together, preferably twisted helically, around the central wire and preferably has a second diameter substantially smaller than the first diameter. Alternatively, the stranded wires can be attached along and parallel to the larger diameter wire, and the latter wire is of a substantially greater length than the stranded wires.

Abstract: A method of bonding sections of a catheter body together in abutting relationship including the steps of providing a temperature resistant polymeric sleeve, which sleeve preferably has a spirally wound metallic wire imbedded between its inner and outer diameters. The sleeve is inserted into ends of tubing segments to be joined together to form a catheter body. Then heat is applied over the area including the sleeve to melt the tubing over the sleeve.