Abstract: The subject invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject in need of such treatment comprising administering to the subject R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof alone or in combination with 2-amino-6-trifluoromethoxy benzothiazole in amounts effective to treat ALS in the subject.

Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an effective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.

Abstract: The combination of a package and plural absorbent pads, e.g., pantiliners. Each of the pads is an elongated generally planar member having a body engaging surface and an opposed liquid barrier surface. Each of the pads is folded along a line extending transversely to the long dimension of the pad so that its body engaging surface forms the inner surface of the folded pad and its liquid barrier surface forms the outer surface of the folded pad. The folded pads are stacked on top of one another. The package can be of various shapes, e.g., a pouch, a parallelepiped gusseted member, etc., and is formed of a flexible sheet material, e.g., a plastic film. It has a hollow interior into which the stack of pads is located. The package includes an openable mouth, e.g., a weakened or breakable line in a portion of the material making up the package, two overlapping edges of the material making up the package, etc.

Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan, or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject.

Abstract: A disposable absorbent article, e.g., a diaper, and a method of making it. The article is arranged to be worn by a wearer to trap and collect fluid waste products, e.g., urine, of the wearer. The article has a flexible chassis and plural tabs for holding the diaper in place on the wearer. The chassis is made up of a top-sheet, a fluid acquisition system, and a fluid absorbent core. The top sheet is formed of a fluid pervious material, e.g., a fibrous material. The core includes fast acting fluid absorbing material, e.g., fluff, and a slow acting fluid absorbing and retaining material, e.g., SAP. The fluid acquisition system comprises a first fluid acquisition layer formed of apertured polymeric, e.g., three dimensional, film and a second fluid acquisition layer, e.g., a fibrous material, secured together and located between the top-sheet and the core, with the first fluid acquisition layer facing the top-sheet and the second fluid acquisition layer facing the core.

Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargy-1-aminoindan, or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject.

Abstract: A disposable absorbent article to trap and collect fluid waste products of a wearer. The pad includes a non-woven top sheet, a fluid acquisitions system, a core, and a polymer cover sheet. The top sheet includes a pair of elasticized flaps extending along its marginal sides, and which are secured in place at the respective ends of the pad, but which stand up on either side of the central portion of the pad so that the pad assumes a cup-like shape. The flaps prevent the egress of fluid laterally from the pad.

Abstract: Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid.

Abstract: A disposable absorbent article, e.g., a diaper, arranged to be worn by a wearer to trap and collect fluid waste products. The article has a flexible chassis made up of a top-sheet, a two layer fluid acquisition system, and a fluid absorbent core.

Abstract: A disposable absorbent article, e.g., a pantiliner, or other absorbent pad. The pad is an elongated generally planar member having a general hour-glass shape periphery including a pair of concave, side sections interconnecting respective ones of a pair of convex end sections. The pad basically comprises a top-sheet, a fluid absorbent core, and a cover sheet. The top sheet is formed of a fluid pervious material, e.g., a non-woven material, and is disposed over the absorbent core. The absorbent core comprises a fluid absorbing material, e.g., cellulosic fluff and super-absorbent particles, and is disposed over the cover sheet. The cover sheet is formed of a fluid impervious material, e.g., a plastic film. The top-sheet, the fluid absorbent core and the cover sheet are bonded, e.g., thermally bonded, together along plural concentric lines located adjacent the periphery of the pad. The plural concentric lines form a barrier resistant to the egress of fluid out of the periphery of the pad.

Abstract: The subject invention provides a method of treating mania in bipolar disorder in a subject comprising administering to the subject a therapeutically effective amount of derivatives of 1-aminoindan or their racemic mixtures, enantiomers, or salts, of the general formula: wherein n is 0 or 1; each of R1 and R2 are hydrogen, C1-C4 alkyl, halogen; R3 is hydrogen, C1-C4 alkyl, hydroxy, C1-C4 alkoxy; R4 is hydrogen, C1-C4 alkyl; R6 is hydrogen, substituted or unsubstituted C1-C12 alkyl, C6-C12 aryl, C7-C12 aralkyl or A—N—R9R10, provided that R6 is not methyl when R1, R2, R3 and R4 are hydrogen atoms, wherein A is substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, and each of R9 and R10 are independently hydrogen, C1-C12 alkyl, C6-C12 aryl, C7-C12 aralkyl, COOtBu, or indanyl; and racemic mixtures, enantiomers, and salts thereof.

Abstract: A disposable absorbent article, e.g., a diaper, arranged to be worn by a wearer to trap and collect fluid waste products, e.g., urine, of the wearer. The article has a flexible chassis and plural tabs for holding the diaper in place on the wearer. The chassis is made up of a top-sheet, a fluid acquisition system, and a fluid absorbent core. The top sheet is formed of a fluid pervious material, e.g., a fibrous material. The core includes fast acting fluid absorbing material, e.g., fluff, and a slow acting fluid absorbing and retaining material, e.g., SAP. The fluid acquisition system comprises a first fluid acquisition layer formed of apertured polymeric, e.g., three dimensional, film and a second fluid acquisition layer, e.g., a fibrous material, secured together and located between the top-sheet and the core, with the first fluid acquisition layer facing the top-sheet and the second fluid acquisition layer facing the core.

Abstract: A disposable absorbent article, e.g., a diaper, feminine hygiene product, adult incontinent product, etc., arranged to be worn by a wearer to trap and collect fluid waste products, e.g., menses, feces and/or urine, of the wearer. The article has a flexible chassis and plural tabs for holding the diaper in place on the wearer. The chassis is made up of a top-sheet, a fluid absorbent core and a skin-treatment agent, e.g., zinc oxide, vitamins A, D and E, allentoin, aluminum hydroxide, Calamine, dimethicone, glycerin, kaolin, shark liver oil, cod liver oil, zinc acetate, lanolin, mineral oil, zinc carbonate, talc, titanium oxides, silver oxides, and combinations thereof. The top sheet is formed of a fluid pervious material, e.g., a fibrous material or a polymeric apertured three dimensional film.

Abstract: Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid.

Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing the same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject.

Abstract: A disposable absorbent article, e.g., a diaper, arranged to be worn by a wearer to trap and collect fluid waste products. The article has a flexible chassis made up of a top-sheet, a two layer fluid acquisition system, and a fluid absorbent core.

Abstract: Pharmaceutical compositions for the treatment of a neurological disorder of neurotrauma or for improving memory in a patient comprising a therapeutically effective amount of S-(−)-N-proparygl-1-aminoindan or a pharmaceutically acceptable salt thereof as active ingredient, and a pharmaceutically active carrier. The pharmaceutical compositions are adapted, in particular for treating a neurological hypoxia or anoxia, neurodegenerative diseases. Parkinson's Disease, Alzheimer's Disease, neurotoxic injury, head trauma injury, spinal trauma injury or any other form of nerve damage.