Patents by Inventor Ruying Lu

Ruying Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10716860
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: July 21, 2020
    Assignees: Matinas BioPharma Nanotechnologies, Inc., Rutgers, The State University of New Jersey
    Inventors: Raphael Mannino, Ruying Lu
  • Publication number: 20200121601
    Abstract: The present application is directed to a cochleate composition including one or more cochleates and at least two antifungal compounds selected from amphotericin B, 5-flucytosine, fluconazole, ketoconazole, ravuconazole, albaconazole, itraconazole, posaconazole, isavuconazole and/or voriconazole. Methods of using the antifungal cochleate formulations are also disclosed.
    Type: Application
    Filed: July 12, 2017
    Publication date: April 23, 2020
    Applicant: Matinas BioPharma Nanotechnologies, Inc.
    Inventors: Raphael J. MANNINO, Ruying LU, Doug F. KLING
  • Publication number: 20180185491
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: November 13, 2017
    Publication date: July 5, 2018
    Inventors: Raphael Mannino, Ruying Lu
  • Publication number: 20180185308
    Abstract: Disclosed are methods of treating anti-inflammatory disease or conditions, typically by orally administering encochleated anti-inflammatory agents, including NSAIDS. Orally administered cochleates have significantly reduced toxicity as compared to non-encochleated anti-inflammatory agents.
    Type: Application
    Filed: June 17, 2016
    Publication date: July 5, 2018
    Inventors: Raphael J. MANNINO, Ruying Lu
  • Publication number: 20180153807
    Abstract: Disclosed are methods of treating mycobacteria infections, such as nontuberculosis mycobacterial (NTM) lung disease and pulmonary tuberculosis, including refractory lung disease, by orally administering encochleated antibiotics, including aminoglycosides, such as amikacin. Orally administered antibiotic cochleates have significantly reduced toxicity as compared to intravenously administered antibiotics.
    Type: Application
    Filed: April 22, 2016
    Publication date: June 7, 2018
    Inventor: Ruying Lu
  • Patent number: 9974745
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: May 22, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Publication number: 20180042849
    Abstract: A cochleate composition is disclosed. Following oral administration of the cochleate composition, the pharmacologically active agent is found at higher concentrations in the tissue relative to plasma. Oral administration of these cochleate compositions also preferentially targets infected or inflamed tissue as compared to tissue in a healthy subject. The cochleate composition contains a size-regulating agent that reduces cochleate particle size, such as a lipid-anchored polynucleotide, a lipid-anchored sugar, a lipid-anchored polypeptide, or a bile salt (such as oxycholate or deoxycholate). Also disclosed are methods of treatment using the cochleate composition and methods of increasing the concentration of a pharmacologically active agent in an infected tissue relative to the concentration of the pharmacologically active agent in the plasma or the tissue of a healthy subject.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Inventors: Raphael J. Mannino, Ruying Lu
  • Patent number: 9775907
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: October 3, 2017
    Assignee: MATINAS BIOPHARMA NANOTECHNOLOGIES, INC.
    Inventors: Raphael Mannino, Ruying Lu
  • Patent number: 9566237
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: February 14, 2017
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
  • Patent number: 9370572
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: June 21, 2016
    Assignee: AQUARIUS BIOTECHNOLOGIES, INC
    Inventors: Raphael Mannino, Ruying Lu
  • Publication number: 20150297725
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: July 30, 2013
    Publication date: October 22, 2015
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, AQUARIUS BIOTECHNOLOGIES, INC.
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20150147380
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20150140074
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 21, 2015
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20140242153
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 28, 2014
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Publication number: 20140220108
    Abstract: The present invention provides, in part, cochleate compositions and methods for making and using same.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 7, 2014
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, COORDINATED PROGRAM DEVELOPMENT, LLC
    Inventors: Ruying Lu, Raphael Mannino
  • Patent number: 8642073
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: February 4, 2014
    Assignees: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Patent number: 8598138
    Abstract: The present invention is directed to siRNA-cochleate compositions that include a siRNA that is associated with a cochleate and a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: December 3, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Ruying Lu, Raphael J. Mannino
  • Publication number: 20130224284
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
    Type: Application
    Filed: April 1, 2013
    Publication date: August 29, 2013
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
  • Publication number: 20120232260
    Abstract: The present invention is directed to cochleate compositions that include a nucleotide that is associated with a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein.
    Type: Application
    Filed: February 9, 2012
    Publication date: September 13, 2012
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Ruying Lu, Raphael J. Mannino
  • Publication number: 20120195932
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for to later addition of cargo moieties are also contemplated.
    Type: Application
    Filed: January 25, 2010
    Publication date: August 2, 2012
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu