Patents by Inventor Ruying Lu

Ruying Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COCHLEATE COMPOSITIONS AND METHODS OF MAKING AND USING SAME
    Publication number: 20140220108
    Abstract: The present invention provides, in part, cochleate compositions and methods for making and using same.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 7, 2014
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, COORDINATED PROGRAM DEVELOPMENT, LLC
    Inventors: Ruying Lu, Raphael Mannino
  • Encochleation methods, cochleates and methods of use
    Patent number: 8642073
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: February 4, 2014
    Assignees: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Amphiphilic nucleotide cochleate compositions and methods of using the same
    Patent number: 8598138
    Abstract: The present invention is directed to siRNA-cochleate compositions that include a siRNA that is associated with a cochleate and a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: December 3, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Ruying Lu, Raphael J. Mannino
  • GEODATE DELIVERY VEHICLES
    Publication number: 20130224284
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
    Type: Application
    Filed: April 1, 2013
    Publication date: August 29, 2013
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
  • AMPHIPHILIC NUCLEOTIDE COCHLEATE COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20120232260
    Abstract: The present invention is directed to cochleate compositions that include a nucleotide that is associated with a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein.
    Type: Application
    Filed: February 9, 2012
    Publication date: September 13, 2012
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Ruying Lu, Raphael J. Mannino
  • Geodate delivery vehicles
    Publication number: 20120195932
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for to later addition of cargo moieties are also contemplated.
    Type: Application
    Filed: January 25, 2010
    Publication date: August 2, 2012
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
  • AMPHIPHILIC NUCLEOTIDE COCHLEATE COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20100178325
    Abstract: The present invention is directed to cochleate compositions that include a nucleotide that is associated with a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein.
    Type: Application
    Filed: August 22, 2007
    Publication date: July 15, 2010
    Applicant: BioDelivery Sciences International, Inc.
    Inventor: Ruying LU
  • Novel encochleation methods, cochleates and methods of use
    Publication number: 20070237814
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Application
    Filed: January 11, 2007
    Publication date: October 11, 2007
    Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
  • Novel encochleation methods, cochleates and methods of use
    Publication number: 20050013854
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: January 20, 2005
    Inventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
  • Geodate delivery vehicles
    Publication number: 20040146551
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
    Type: Application
    Filed: November 3, 2003
    Publication date: July 29, 2004
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu