Abstract: Provided herein are systems of modulating gene expression, methods of use thereof, and cells engineered thereof for the purpose of differentiating cells, for example hematopoietic cells.

Abstract: Provided herein are systems of modulating gene expression, methods of use thereof, and cells engineered thereof for the purpose of differentiating cells, for example chondroprogenitor cells.

Abstract: Provided herein are systems of modulating gene expression, methods of use thereof, and cells engineered thereof for the purpose of differentiating cells, for example beta cells.

Abstract: Provided herein are systems of modulating gene expression, methods of use thereof, and cells engineered thereof for the purpose of differentiating cells, for example immune cells.

Abstract: Provided herein are systems of modulating gene expression and methods of use thereof for converting cells of one type to another type (e.g. reprogramming of stem cells into tissue-specific progenitor cells).

Abstract: Provided herein are systems of modulating gene expression and methods of use thereof for converting cells of one type to another type (e.g., reprogramming of differentiated cells into stem cells).

Abstract: Provided herein are systems of regulating expression of a cargo (e.g., a guide nucleic acid) from a polynucleotide sequence (e.g., a vector).

Abstract: Described herein are compositions of matter for novel universal dynamic crosslinkers (UDCs) and the shortest closed-loop process for upcycling of any plastics, including post-consumer plastic waste and immiscible plastic mixtures enabled by UDCs. We discovered that the specifically designed UDCs can dynamically crosslink any plastics, and more importantly mixed immiscible plastics into compatibilized living grafted multiblock copolymers. Our studies show that such UDCs can reactivate mixed plastic dead chains and dynamically crosslink them into compatibilized multiblock copolymers. The in situ generated dynamic thermosets exhibit intrinsic reprocessability as well as enhanced tensile strength and creep resistance, relative to virgin plastics. This approach avoids the need for de/reconstruction and thus provides the maximum recovery of the endowed energy and materials value of the individual plastics.

Abstract: A system receives a first indication associated with a first device picking up a package and transmits a first instruction to the first device to travel to a location associated with transferring the package to a second device. The system may transmit a second instruction to the second device to travel to the location to receive the package from the first device. The system receives a second indication associated with the package being transferred from the first device to the second device at the location. One or more third devices may meet at the location to transfer packages to the second device. In some instances, the location may be determined based at least in part on a current location of the first device and/or a current location of the second device.

Abstract: A method for developing or improving a process for producing a product from a material comprising steps of acquiring the composition for at least two slurries as raw material data (17) for the CMP based manufacturing process and its relevant parameters (2) by using a Data Collecting computer (9); physically performing specific method steps of a CMP process; measuring relevant parameters of the used slurries and the physically performed CMP process to determine the CMP process performance by using the Data Collecting computer (9); analyzing the measured data about the relevant parameters with a specific software performed on an Analyzing computer (11) by creating for the software and applying with it a predictive model using Machine Learning to understand the intercorrelation of the different parameters and using the results to improve the CMP process performance and the resulting product quality of the CMP based manufacturing process.

Abstract: A method for developing or improving a process for producing a product from a material comprising steps of acquiring the composition for at least two slurries as raw material data (17) for the CMP based manufacturing process and its relevant parameters (2) by using a Data Collecting computer (9); physically performing specific method steps of a CMP process; measuring relevant parameters of the used slurries and the physically performed CMP process to determine the CMP process performance by using the Data Collecting computer (9); analyzing the measured data about the relevant parameters with a specific software performed on an Analyzing computer (11) by creating for the software and applying with it a predictive model using Machine Learning to understand the intercorrelation of the different parameters and using the results to improve the CMP process performance and the resulting product quality of the CMP based manufacturing process.

Abstract: Disclosed herein are cells including pluripotent stem cells that conditionally express an immunosuppressive factor and related methods of their use and generation. In some embodiments, the cells disclosed do not express MHC I and MHC II human leukocyte antigens, and in some cases, also do not express one or more TCR complexes. In some embodiments, hypoimmunogenicity of the cells is controlled by activation of a controllable expression system upon contacting the cells with a specific factor or agent.

Abstract: A system receives a first indication associated with a first device picking up a package and transmits a first instruction to the first device to travel to a location associated with transferring the package to a second device. The system may transmit a second instruction to the second device to travel to the location to receive the package from the first device. The system receives a second indication associated with the package being transferred from the first device to the second device at the location. One or more third devices may meet at the location to transfer packages to the second device. In some instances, the location may be determined based at least in part on a current location of the first device and/or a current location of the second device.

Abstract: With respect to a transfer facility configured to optimize package transfers therethrough, a container housing packages may be delivered to a first floor of the transfer facility. The packages may be transported to consolidation stations based on destinations associated therewith. In some examples, the packages may be bound for a single destination and thus transported to a single consolidation station. In some examples, the packages may be bound for multiple destinations and thus transported to a second floor of the transfer facility for sortation. A destination and mode of transportation associated with the package may be determined at an induction station on the second floor, as well as a consolidation station associated therewith. A drive unit may insert the package into a chute for transit down a slide to the consolidation station, where it may be placed into another container for shipment to the destination via the mode of transportation.

Abstract: With respect to a transfer facility configured to optimize package transfers therethrough, a container housing packages may be delivered to a first floor of the transfer facility. The packages may be transported to consolidation stations based on destinations associated therewith. In some examples, the packages may be bound for a single destination and thus transported to a single consolidation station. In some examples, the packages may be bound for multiple destinations and thus transported to a second floor of the transfer facility for sortation. A destination and mode of transportation associated with the package may be determined at an induction station on the second floor, as well as a consolidation station associated therewith. A drive unit may insert the package into a chute for transit down a slide to the consolidation station, where it may be placed into another container for shipment to the destination via the mode of transportation.

Abstract: Techniques for controlling movement of a mobile drive unit within a workspace are described. In an example, a system may access a map of the workspace. The map defines a policy for the movement of the mobile drive unit within the workspace based on a volume of the workspace associated with a fire shutter. The fire shutter is located within the workspace and is operable to manage a spread of a fire within the workspace. The system may generate at least a portion of a movement path for the mobile drive unit within the workspace based on the map and on an event for transporting material from a location in the workspace. The portion of the movement path is in compliance with the policy defined in the map. The system provides at least the portion of the movement path to the mobile drive unit over a data network.

Abstract: A combinatorial screening method and system are provided. The combinatorial system and method provide rapid data generation for characterization of phase change material. The characterization data is collected through a multipoint probe card where multiple regions are characterized in a single annealing cycle.

Abstract: A combinatorial screening method and system are provided. The combinatorial system and method provide rapid data generation for characterization of phase change material. The characterization data is collected through a multipoint probe card where multiple regions are characterized in a single annealing cycle.

Abstract: A nonvolatile resistive memory element includes a host oxide formed from an interfacial oxide layer. The interfacial oxide layer is formed on the surface of a deposited electrode layer via in situ or post-deposition surface oxidation treatments.