Abstract: This disclosure relates to methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD). This disclosure also relates to methods of sequestering copper in a subject or of mobilizing copper into plasma in a subject.

Abstract: A dishwasher appliance includes a water supply for providing water into a wash tub, an additive dispensing system comprising a bulk storage tank defining a plurality of additive chambers and a pump assembly for selectively urging a flow of wash additive from the plurality of additive chambers into the wash chamber, a turbidity sensor configured to measure a turbidity of wash fluid collected in the wash chamber, and a controller. The controller is configured to operate the water supply to add a volume of water into the wash tub, obtain a turbidity reading using the turbidity sensor, determine a target additive volume based on the turbidity reading, and operate the additive dispensing system to dispense the target additive volume into the wash tub.

Abstract: A dispenser assembly includes a housing including a plurality of inlets and an outlet. The housing defines a first portion of a flow path. A rotatable disk is positioned within the housing, and the rotatable disk includes a groove in a top side of the rotatable disk. The groove defines a second portion of the flow path. A positioning wheel is coupled to the rotatable disk. A motor is mechanically coupled to the positioning wheel for driving rotation of the rotatable disk about an axis to align the groove of the rotatable disk with one of the plurality of inlets. When the groove of the rotatable disk engages with one of the plurality of inlets, the first portion of the flow path and the second portion of the flow path mesh to provide the flow path between one of the plurality of inlets and the outlet.

Abstract: There are disclosed compounds of the following formula (I): or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for distributing machine learning workloads, e.g., computations for training a neural network or computing an inference using a neural network, across multiple hardware accelerators.

Abstract: A method for operating a laundry apparatus, the laundry apparatus including a tub and a detergent dispenser, the method including initiating a washing cycle of a washing load; supplying a first fill of heated water and a dose of detergent to the tub via the detergent dispenser; performing a first agitation phase of the washing cycle; determining that a two-phase heated water fill condition exists; supplying a second fill of heated water to the tub; and performing a second agitation phase of the washing cycle.

Abstract: A self-branching polyetherimide comprising a first repeating unit derived from polymerization of the aromatic dianhydride and a first diamine, wherein the first diamine comprises a carboxyl-substituted C6-24 aromatic hydrocarbon group; and optionally, a second repeating unit derived from polymerization of an aromatic dianhydride and a second diamine, wherein the second diamine comprises a C1-30 divalent hydrocarbon group, optionally comprising 1 to 4 heteroatoms, wherein the self-branching polyetherimide is end-capped with phthalic anhydride.

Abstract: A method for producing a tandem sub for a perforating gun system includes positioning an electrically conductive signal bar in a central passage of a tubular housing of the tandem sub, and injecting a mold material into an annulus formed between an outer surface of the signal bar and an inner surface of the tubular housing that sealably adheres to both the signal bar and the tubular housing.

Abstract: An augmented reality device includes a projector, projector optics optically coupled to the projector, and a substrate structure including a substrate having an incident surface and an opposing exit surface and a first variable thickness film coupled to the incident surface. The substrate structure can also include a first combined pupil expander coupled to the first variable thickness film, a second variable thickness film coupled to the opposing exit surface, an incoupling grating coupled to the opposing exit surface, and a second combined pupil expander coupled to the opposing exit surface.

Abstract: A refrigerating appliance includes a cabinet having an inner liner that defines at least one aperture for accessing a refrigerating compartment. A door is operably coupled to the cabinet and is operable between open and closed positions. A plurality of storage surfaces is positioned within the refrigerating compartment. Each storage surface is adapted to receive at least one temporarily stored item. A scanning apparatus is adapted to record data related to the storage surfaces and the at least one temporarily stored item. The scanning apparatus conducts first and second data capturing phases. The secondary data recorded during the second data capturing phase is compared against previous data recorded during the first data capturing phase to create a current inventory manifest. The current inventory manifest is compared with a set of predetermined parameters related to the at least one temporarily stored item to selectively provide an output.

Abstract: A processor may query a database of media compositions with a query specifying at least one attribute from among a plurality of attributes of media compositions. In response to the querying, the processor may receive a returned plurality of the media compositions having the at least one attribute. The processor may arrange the returned plurality of the media compositions into a sequence according to at least one of the plurality of attributes. The processor may render the sequence into a metacomposition, which may be displayed by at least one display device.

Abstract: Techniques are provided for metadata management for enabling automated switchover in accordance with a configuration of storage solution that expresses a preference for either maintaining availability (e.g., a non-zero RPO mode) of the storage solution or avoiding data loss (e.g., a zero RPO mode). In one example, responsive to detecting a switchover trigger event, a node of a local cluster of a cross-site storage solution determines whether performance of an automated switchover from a failed cluster to a surviving cluster of the cross-site storage solution is enabled. Responsive to an affirmative determination, the node selectively proceeds with the automated switchover based on the configuration.

Abstract: This disclosure describes a method for retrofitting an existing plant. The method includes adding a fractionation process to separate bran from other components in a feedstock to the existing plant, adding a pretreatment process downstream of the fractionation process, the pretreatment process configured to receive the bran and utilize water and heat to break down cellulose and hemicellulose in the bran; adding a hydrolysis and cellulosic fermentation process downstream of the pretreatment process and upstream of the fermentation process to hydrolyze the bran with a cellulase enzyme complex cocktail and to ferment with an organism to produce cellulosic beer; and combining the cellulosic beer with starch from the grain in the existing plant into the fermentation process to increase overall yield per feedstock unit in the existing plant.

Abstract: The present invention provides a compound of Formula I: wherein R1 is H, halogen, C1-C3 alkyl, or C1-C3 alkoxy; R2 is H or halogen; and X is O, OCH2, or CH2, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis, rheumatoid arthritis, and lupus nephritis.

Abstract: Techniques are provided for metadata management for enabling automated switchover. An initial quorum vote may be performed before a node executes an operation associated with metadata comprising operational information and switchover information. After the initial quorum vote is performed, the node executes the operation upon one or more mailbox storage devices. Once the operation has executed, a final quorum vote is performed. The final quorum vote and the initial quorum vote are compared to determine whether the operation is to be designated as successful or failed, and whether any additional actions are to be performed.

Abstract: An object processing system is disclosed that includes a mobile system for moving from a proximal base toward a plurality of objects to be processed, and a programmable motion device supported on the mobile unit at a proximal end of the programmable motion device, the programmable motion device including an end-effector at a distal end thereof, the end-effector including a first stationary portion that remains stationary with respect to the distal end of the programmable motion device, and a second movable portion that moves with respect to the first stationary portion, the second movable portion for contacting at least one object of the plurality of objects for urging the at least one object from the plurality of objects toward the mobile system.

Abstract: Techniques and systems include assessing health risk and predicting health events of a patient using measured biosignals. The biosignals may be transformed into a photoplethysmography (PPG) signal or pseudo PPG signal, for example, to measure blood volume changes in the patient's blood flow to derive data indicating a disease state or health-related characteristic, such as blood oxygen level, blood glucose level, heart rate variability, hemoglobin, respiration rate, or arrhythmia. Further, the biosignals can include vocal signals, health labels, and self-reported data related to a patient's health. Assessment and prediction techniques include training an artificial intelligence (AI) model to create embedding vectors based on the measured biosignal(s) that are then ingested by a prediction model to assess and/or predict a patient's health risk and/or health events.

Abstract: A system performs static program analysis with artifact reuse. The system identifies artifacts associated with the software program being analyzed. The system processes the identified artifacts for performing static program analysis and transmits either the artifacts or identifiers for the artifacts to a second processing device for performing program analysis. The second processing device receives the artifacts and uses the received identifiers to retrieve the artifacts from a networked storage system. The second device also retrieves stored summaries of previous program analysis from the networked storage system. The program analysis uses the retrieved artifacts to generate work units for static program analysis. The analysis is performed only for those work units that are determined to remain unchanged from previous static program analysis cycles.

Abstract: The disclosure generally relates to compositions and methods of treating a disease by administering compositions disclosed herein. Provided herein are DSG2 fusion polypeptides and related methods including methods of treatment and improving cardiomyocyte function.

Abstract: The present disclosure relates to a method for making a dialkyl malonate ester, including a) acidifying a malonate composition comprising: at least 30 wt % based on malonic acid equivalents of a compound of formula I: where M+ is a Group I alkali metal cation or ammonium cation. The malonate composition optionally includes: a compound of formula II: and/or malonic acid. Step a) comprises contacting an organic alcohol and an inorganic acid with the malonate composition to form a first acidified malonate composition comprising: a compound of formula IV: a compound of formula V: and/or malonic acid. R1 and R2 are independently (C1-C8)alkyl.