Abstract: The present invention relates to A multicomponent system wherein a first component is an engineered antigen-presenting cell (eAPC) designated component A and a second component is a genetic donor vector, designated component C, for delivery of one or more ORFs encoding an analyte antigen-presenting complex (aAPX) and/or an analyte antigenic molecule (aAM), wherein component A a. Lacks endogenous surface expression of at least one family of aAPX and/or aAM and b. Contains at least two genomic receiver sites, designated component B and component D, each for integration of at least one ORF encoding at least one aAPX and/or aAM, and component C is matched to a component B, and wherein component C is designed to deliver c. A single ORF encoding at least one aAPX and/or aAM or d. Two or more ORF encoding at least one aAPX and/or aAM, wherein the genomic receiver sites B and D are synthetic constructs designed for recombinase mediated exchange (RMCE).

Abstract: Methods for creating a location map using antennas in an ultra-wide band (UWB) network including positioning a plurality of stationary antennas in a target environment; determining a position of each of the plurality of stationary antennas relative to one another; obtaining location measurements relative to a mobile device as it moves around the target environment; generating a location map using the location measurements, the location map illustrating a path traveled by the mobile device relative to the plurality of stationary antennas; and displaying the location map including straight line segments corresponding to the path traveled by the mobile device.

Abstract: A motorized roller shade configured to connect to a power over Ethernet network includes a motor for rotating the shade to roll and unroll shade material to and from a roller tube to raise and lower the shade. A rechargeable battery positioned in the roller tube provides power to the motor and to logic and control circuitry also positioned within the roller tube. The logic and control circuitry charges the battery though power derived from the power over Ethernet network, and controls the operation of the motor to achieve a desired target velocity. Synchronized operation of multiple motorized roller shades is achieved though autonomous operation of the shades by their corresponding logic and control circuitry. In exemplary embodiments, a lighting element controlled by the logic and control circuitry allows controlled lighting of the shade.

Abstract: An indoor location is mapped into a grid comprising grid cells, each cell associated with items or objects detected as being present in the corresponding cell. The grid, grid cells, and linked items and/or objects are generated and updated using an Augmented Reality (AR) algorithm that maps a physical environment into cells and measures distances and directions within the environment relative to each cell. Walking paths (routes) to the items within the indoor location are generated using the grid information. As a user walks a path, the user's position within the indoor location is mapped and tracked to the cells and the path revised based on the user's actual position. A user device provides video via an AR application to track the user's position; a rendering of the position and path are superimposed within the video being viewed by the user on the user-operated device.

Abstract: Described herein is a computer implemented method for automatically generating a design. The method includes receiving an input prompt for generating the design and generating a design outline based on the input prompt. The design outline includes a style descriptor for the design. The method further includes retrieving a design template based on the design outline. The design template includes a placeholder design element. The method further includes retrieving at least one design element for the placeholder element. The design is generated by populating the placeholder element with the design element.

Abstract: Techniques for determining calibration data associated with a radio frequency (RF) testing environment are discussed herein. For example, an RF signal can be input to the RF enclosure and selectively applied to discrete attenuators. The attenuators can attenuate a strength of the signal and a signal strength can be measured by various user equipment (UEs) that are located within an RF enclosure. In some examples, a plurality of measured reference signal received power (RSRP) values can be determined by a plurality of UEs associated with a particular attenuation level. Different attenuation levels can be measured, and an average attenuation can be determined for attenuation steps. Measured attenuation steps can be extrapolated to other attenuation levels to expedite the calibration process. Then, a testing plan can be applied to the RF enclosure and the calibration data can be used to ensure accurate signals for testing UEs.

Abstract: The apparatuses described herein relate to preparation of a meat product. Apparatuses, systems comprising the apparatuses, and methods of making and use the systems and apparatuses are described herein. These are useful for controlling one or more of growth on and separation of a meat product from an enclosed substrate. The apparatuses and systems are configured to receive fluid and grow the meat product and/or separate the meat product from the substrate in a scalable manner.

Abstract: Methods and systems providing fluid flow to an endoscope. A container and tube set configured to couple to an endoscope may comprise a first container configured to contain a fluid, a first water supply tube including a first lumen extending therethrough and in fluid communication with the first container, a branched connector positioned in line with the first water supply tube and including a first fluid inlet, a first fluid outlet, and a second fluid outlet, a second container having a second fluid inlet in selective fluid communication with the second fluid outlet of the branched connector, a flow control valve positioned to obstruct flow between the second fluid outlet of the branched connector and the second fluid inlet of the second container, and a second water supply tube including a second lumen extending therethrough and in selective fluid communication with the bottom portion of the second container.

Abstract: This disclosure relates to methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD). This disclosure also relates to methods of sequestering copper in a subject or of mobilizing copper into plasma in a subject.

Abstract: A dispenser assembly includes a housing including a plurality of inlets and an outlet. The housing defines a first portion of a flow path. A rotatable disk is positioned within the housing, and the rotatable disk includes a groove in a top side of the rotatable disk. The groove defines a second portion of the flow path. A positioning wheel is coupled to the rotatable disk. A motor is mechanically coupled to the positioning wheel for driving rotation of the rotatable disk about an axis to align the groove of the rotatable disk with one of the plurality of inlets. When the groove of the rotatable disk engages with one of the plurality of inlets, the first portion of the flow path and the second portion of the flow path mesh to provide the flow path between one of the plurality of inlets and the outlet.

Abstract: A dishwasher appliance includes a water supply for providing water into a wash tub, an additive dispensing system comprising a bulk storage tank defining a plurality of additive chambers and a pump assembly for selectively urging a flow of wash additive from the plurality of additive chambers into the wash chamber, a turbidity sensor configured to measure a turbidity of wash fluid collected in the wash chamber, and a controller. The controller is configured to operate the water supply to add a volume of water into the wash tub, obtain a turbidity reading using the turbidity sensor, determine a target additive volume based on the turbidity reading, and operate the additive dispensing system to dispense the target additive volume into the wash tub.

Abstract: There are disclosed compounds of the following formula (I): or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for distributing machine learning workloads, e.g., computations for training a neural network or computing an inference using a neural network, across multiple hardware accelerators.

Abstract: A method for operating a laundry apparatus, the laundry apparatus including a tub and a detergent dispenser, the method including initiating a washing cycle of a washing load; supplying a first fill of heated water and a dose of detergent to the tub via the detergent dispenser; performing a first agitation phase of the washing cycle; determining that a two-phase heated water fill condition exists; supplying a second fill of heated water to the tub; and performing a second agitation phase of the washing cycle.

Abstract: A self-branching polyetherimide comprising a first repeating unit derived from polymerization of the aromatic dianhydride and a first diamine, wherein the first diamine comprises a carboxyl-substituted C6-24 aromatic hydrocarbon group; and optionally, a second repeating unit derived from polymerization of an aromatic dianhydride and a second diamine, wherein the second diamine comprises a C1-30 divalent hydrocarbon group, optionally comprising 1 to 4 heteroatoms, wherein the self-branching polyetherimide is end-capped with phthalic anhydride.

Abstract: A method for producing a tandem sub for a perforating gun system includes positioning an electrically conductive signal bar in a central passage of a tubular housing of the tandem sub, and injecting a mold material into an annulus formed between an outer surface of the signal bar and an inner surface of the tubular housing that sealably adheres to both the signal bar and the tubular housing.

Abstract: A refrigerating appliance includes a cabinet having an inner liner that defines at least one aperture for accessing a refrigerating compartment. A door is operably coupled to the cabinet and is operable between open and closed positions. A plurality of storage surfaces is positioned within the refrigerating compartment. Each storage surface is adapted to receive at least one temporarily stored item. A scanning apparatus is adapted to record data related to the storage surfaces and the at least one temporarily stored item. The scanning apparatus conducts first and second data capturing phases. The secondary data recorded during the second data capturing phase is compared against previous data recorded during the first data capturing phase to create a current inventory manifest. The current inventory manifest is compared with a set of predetermined parameters related to the at least one temporarily stored item to selectively provide an output.

Abstract: An augmented reality device includes a projector, projector optics optically coupled to the projector, and a substrate structure including a substrate having an incident surface and an opposing exit surface and a first variable thickness film coupled to the incident surface. The substrate structure can also include a first combined pupil expander coupled to the first variable thickness film, a second variable thickness film coupled to the opposing exit surface, an incoupling grating coupled to the opposing exit surface, and a second combined pupil expander coupled to the opposing exit surface.

Abstract: A processor may query a database of media compositions with a query specifying at least one attribute from among a plurality of attributes of media compositions. In response to the querying, the processor may receive a returned plurality of the media compositions having the at least one attribute. The processor may arrange the returned plurality of the media compositions into a sequence according to at least one of the plurality of attributes. The processor may render the sequence into a metacomposition, which may be displayed by at least one display device.

Abstract: Techniques are provided for metadata management for enabling automated switchover in accordance with a configuration of storage solution that expresses a preference for either maintaining availability (e.g., a non-zero RPO mode) of the storage solution or avoiding data loss (e.g., a zero RPO mode). In one example, responsive to detecting a switchover trigger event, a node of a local cluster of a cross-site storage solution determines whether performance of an automated switchover from a failed cluster to a surviving cluster of the cross-site storage solution is enabled. Responsive to an affirmative determination, the node selectively proceeds with the automated switchover based on the configuration.