Abstract: A perforating gun system includes an outer housing, a charge carrier assembly slidably receivable in the outer housing, wherein the charge carrier assembly includes a charge carrier having a central axis, a first endplate coupled to a first end of the charge carrier, and a second endplate coupled to a second end of the charge carrier, and an annular initiator assembly connectable to the charge carrier assembly, wherein the initiator assembly has a central opening whereby a central axis of the initiator assembly extends centrally through the central opening and parallel with the central axis of the charge carrier, wherein the initiator assembly is configured to detonate a detonator of the perforating gun system in response to receiving a firing signal.

Abstract: A method for producing a tandem sub for a perforating gun system includes positioning an electrically conductive signal bar in a central passage of a tubular housing of the tandem sub, and injecting a mold material into an annulus formed between an outer surface of the signal bar and an inner surface of the tubular housing that sealably adheres to both the signal bar and the tubular housing.

Abstract: The presence of a plug connector with a port is detected through a detection circuit activated by a port shutter. Transitioning the port shutter between the closed (i.e., blocking the port) position and the open position actuates and deactuates the detection circuit.

Abstract: Disclosed are example embodiments of systems, method, and devices for generating audio assets. The example method includes receiving an input including at least one of audio, text, video, Java Script Object Notation (JSON), Extensible Markup Language (XML), Really Simple Syndication (RSS). The example method includes receiving configuration inputs including at least one of configure language, gender, and persona. The example method includes preparing for processing based on the at least one of configure language, gender, and persona. The example method includes processing the input based on the configuration inputs, the processing including at least one of transcribing, translating, brand safety, enrichment, generating custom Speech Synthesis Markup Language (SSML), and including generating an audio clip. The example method includes delivering the audio clip.

Abstract: The disclosure generally relates to compositions and methods of treating COVID-19 by administering compositions disclosed herein. The methods also include the treatment of post-COVID-19 syndrome and cardiomyopathies using compositions described in the present disclosure.

Abstract: Provided herein are immunomodulatory proteins and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making the immunomodulatory proteins and compositions. The immunomodulatory proteins provided herein are useful in pharmaceutical compositions and methods of treating IL-10 responsive diseases.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining turbidity of water using machine learning. One of the methods includes obtaining, by a camera, an image of water; detecting, using a blob detector, a plurality of blobs in the image that represent particles suspended in the water; determining a distribution of the plurality of blobs; determining, from the distribution of the plurality of blobs, a measurement associated with turbidity of the water; and providing a signal associated with the measurement.

Abstract: The present invention provides a compound of Formula I: wherein R is H or R1 is H, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C2-C3 alkenyl, OCF3, R2 is H, halogen, C1-C3 alkyl, C1-C3 alkoxy, or C2-C4 alkenyl; R3 is NH2, or CH2NH2; and X is O, OCH2, OCH2CH2, OCH(CH3), CH2O, SCH2, CH2S, CH2, NHCH2, CH2NH, N(CH3)CH2, CH2CH2, C?C, or a bond, wherein X is connected to phenyl ring A at the ortho or the meta position, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis and rheumatoid arthritis.

Abstract: A computer-implemented method for state synchronization may include (i) identifying a type of a message from a client device to a server that includes an intended update to content hosted on the server, (ii) determining, based on the type of the message, whether to direct the message to a best-effort publisher-subscriber module or a lossless publisher-subscriber, (iii) directing the message to the best-effort publisher-subscriber module based on the type of the message, (iv) identifying a different type of an additional message from the client device to the server that includes a new intended update to the content, and (v) directing the additional message to the lossless publisher-subscriber module based on the different type of the additional message. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A novel maize variety designated ARC-9913C and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety ARC-9913C with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into ARC-9913C through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety ARC-9913C, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety ARC-9913C are provided. Methods for producing maize varieties derived from maize variety ARC-9913C and methods of using maize variety ARC-9913C are disclosed.

Abstract: An intake air circuit is structured to transmit intake air from a turbocharger compressor to an intake manifold of an engine. A charge air cooler (“CAC”), a bypass line, and a bypass heater are each positioned along the intake air circuit in parallel with each other. A first control valve is structured to controllably divert the intake air around the CAC. A second control valve is structured to controllably divert the intake air around at least one of the bypass line and the bypass heater. A controller operatively coupled to each of the engine, and the first and second control valves is structured to control each of the first and second control valves to cause the intake air to flow along a determined desired flow path based on each of measured ambient temperature and measured engine load.

Abstract: Disclosed herein are methods, systems, and processes to configure and facilitate selective and granular multi-customer support access in cloud-based cybersecurity computing environments. A request to authorize a multi-customer support account (MCSA) is received. Customer accounts that include an anchor tenant customer account and several secondary tenant customer accounts as well as a set of applications associated with the customer accounts are identified. The MCSA is configured to selectively access customer accounts and granularly access associated applications by being designated with a set of varying access limits for the anchor tenant customer account and another set of varying access limits for the secondary tenant customer accounts, each set of varying access limits being made applicable to various instances of applications associated with each of those customer accounts.

Abstract: The invention describes novel steroidal compounds, compositions containing the same, and methods of using the same as SREBP inhibitors, as LXR agonists, or as dual modulators of SREBP and LXR, to treat SREBP and/or LXR mediated diseases.

Abstract: Embodiments of the present disclosure provide a system, method and framework that facilitate and simplify computing solutions requirements or description breakdown into user-driven, autonomous system of decentralized distributed intents fulfilled by shapes (software and software stack) organized and implemented as essential, minimized capabilities effortlessly extended, assembled, swapped, and re-organized; simplifying and accelerating prototyping, development, packaging, deployment, and maintenance of a solution’s lifecycle, e.g., an Artificial Intelligence system. Embodiments of the system, framework, and method provide the infrastructure for defining intents and shapes, support green computing and continuous updates, and eliminate endless incremental technology refreshes with minimum operational impact to a deployed solution. Inherent to the system, framework, method is a dramatic reduction in cybersecurity vulnerabilities and attack surfaces among other benefits.

Abstract: The present invention provides a compound of Formula I: wherein R is H or R1 is H, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C2-C3 alkenyl, OCF3, R2 is H, halogen, C1-C3 alkyl, C1-C3 alkoxy, or C2-C4 alkenyl; R3 is NH2, or CH2NH2; and X is O, OCH2, OCH2CH2, OCH(CH3), CH2O, SCH2, CH2S, CH2, NHCH2, CH2NH, N(CH3)CH2, CH2CH2, C?C, or a bond, wherein X is connected to phenyl ring A at the ortho or the meta position, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis and rheumatoid arthritis.

Abstract: The present invention relates to a two-part device, wherein a first part is an engineered antigen-presenting cell system (eAPCS), and a second part is an engineered TCR-presenting cell system (eTPCS).

Abstract: Embodiments of the present disclosure provide a system, method and framework that facilitate and simplify computing solutions requirements or description breakdown into user-driven, autonomous system of decentralized distributed intents fulfilled by shapes (software and software stack) organized and implemented as essential, minimized capabilities effortlessly extended, assembled, swapped, and re-organized; simplifying and accelerating prototyping, development, packaging, deployment, and maintenance of a solution's lifecycle, e.g., an Artificial Intelligence system. Embodiments of the system, framework, and method provide the infrastructure for defining intents and shapes, support green computing and continuous updates, and eliminate endless incremental technology refreshes with minimum operational impact to a deployed solution. Inherent to the system, framework, method is a dramatic reduction in cybersecurity vulnerabilities and attack surfaces among other benefits.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining turbidity of water using machine learning. One of the methods includes obtaining, by a camera, an image of water; detecting, using a blob detector, a plurality of blobs in the image that represent particles suspended in the water; determining a distribution of the plurality of blobs; determining, from the distribution of the plurality of blobs, a measurement associated with turbidity of the water; and providing a signal associated with the measurement.

Abstract: A method for classifying magnetic resonance imaging (MRI) pulse sequences includes receiving medical imaging data associated with an MRI scan, determining one or more pulse sequence characteristics for the medical imaging data using a machine learning model, wherein the medical imaging data is provided as an input to the machine learning model and wherein the machine learning model outputs a classification for each of the one or more pulse sequence characteristics, and updating a database containing the medical imaging data to include the one or more pulse sequence characteristics in association with the medical imaging data.

Abstract: Systems and methods for managing software resources such as machine learning/artificial intelligence models. The system includes a number of components that provide versioning services to both software resources and to data sets. A data storage component also addresses storage/retrieval functions for the system. A user interface element is also present to provide users with both a GUI and a command line interface. An assessment element assesses user selected software assets for project inclusion, with the assessment being based on good software development principles and practices. Once a project of selected software assets has passed the assessment stage, the software assets are pipelined for execution by an execution unit. The outputs of the execution unit are sent to a data output module automatically populates predetermined and preconfigured templates with the outputs to produce reports. The outputs may be final outputs or they may be intermediate results produced by the software assets.