Abstract: A dome lens extending upwardly about a center axis A and outwardly in a radial direction R, having: a first portion forming a first annular ring about the center axis A that includes a first inner surface that is convex, and being oriented so that a first tangent to the first inner surface is at a first angle to the center axis A that is less than forty-five degrees; a second portion being continuous with the first portion and forming a second annular ring about the center axis A and including a second inner surface that is convex, and being oriented so a second tangent to the second inner surface is canted toward the center axis A; a third portion being continuous with the second portion to enclose the lens, forming an annular solid disk about the center axis A, and including a third inner surface that is convex.

Abstract: A modular surgical retractor including a handle and a blade. The handle includes a base and a neck. The neck projects from an end of the base to a tail region. The blade includes a head section and a blade member. The head section includes opposing side walls and a floor combining to define a slot sized to receive the neck. The blade member projects from the head section. The blade is removably attached to the handle. In some embodiments, a light source, such as an LED, is disposed within the neck and arranged to emit light along a face of the blade member. Two or more additional blades are provided, each additional blade including the head section and a differently configured blade member.

Abstract: Provided are methods, systems, and computer products for genotyping polyploid organisms, as well as diploid organisms. The provided methods use an allele-intensity model to generate cluster definitions. The allele-intensity model relates allele counts of different genotypes to signal intensities generated by the genotyping platform. The model also includes a capability to update cluster positions obtained from a maximum likelihood model using a Bayesian method.

Abstract: A modular surgical retractor including a handle and a blade. The handle includes a base and a neck. The neck projects from an end of the base to a tail region. The blade includes a head section and a blade member. The head section includes opposing side walls and a floor combining to define a slot sized to receive the neck. The blade member projects from the head section. The blade is removably attached to the handle. In an attached state, an attachment face of each side wall contacts the end of the base, and the floor contacts the tail region. In some embodiments, a light source, such as an LED, is disposed within the neck and arranged to emit light along a face of the blade member. Two or more additional blades are provided, each additional blade including the head section and a differently configured blade member.

Abstract: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: The disclosed embodiments concern index oligonucleotides configured to identify sources of samples of nucleic acids and methods, apparatus, systems and computer program products for identifying and making the index oligonucleotides. In some implementations, the index oligonucleotides include a set of index sequences, a Hamming distance between any two index sequences of the set of index sequences meeting one or more criteria. System, apparatus, and computer program products are also provided for determining a sequence of interest using the index oligonucleotides.

Abstract: The disclosed embodiments concern index oligonucleotides configured to identify sources of samples of nucleic acids and methods, apparatus, systems and computer program products for identifying and making the index oligonucleotides. In some implementations, the index oligonucleotides include a set of index sequences, a Hamming distance between any two index sequences of the set of index sequences meeting one or more criteria. System, apparatus, and computer program products are also provided for determining a sequence of interest using the index oligonucleotides.

Abstract: A modular surgical retractor including a handle and a blade. The handle includes a base and a neck. The neck projects from an end of the base to a tail region. The blade includes a head section and a blade member. The head section includes opposing side walls and a floor combining to define a slot sized to receive the neck. The blade member projects from the head section. The blade is removably attached to the handle. In an attached state, an attachment face of each side wall contacts the end of the base, and the floor contacts the tail region. In some embodiments, a light source, such as an LED, is disposed within the neck and arranged to emit light along a face of the blade member. Two or more additional blades are provided, each additional blade including the head section and a differently configured blade member.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: A removable pedal positioner to engage a crank arm and a pedal of a bicycle to position the pedal in a generally horizontal position. One embodiment comprises a bridge, at least one prong, and a mounting post. The mounting post engages the crank arm while the at least one prong extends past the crank arm to position the pedal in a generally horizontal position. In other embodiments, the positioner utilizes a flexible clamp to secure the positioner to the crank arm thereby positioning the pedal in a generally horizontal position. Upon rotation of the pedal, the device disengages from the crank arm.

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.