Abstract: A luminaire comprising a heat sink, a light source and a light guide. The light source is carried by the heat sink and configured to emit a source light. The light source includes a heat spreader having an inner surface and an outer surface, and a plurality of light-emitting diodes (LEDs) carried by a circuit board and disposed generally along an outer peripheral perimeter portion of the inner surface of the heat spreader, and positioned in thermal communication with the heat spreader. The light guide includes a lens with a plurality of optical elements disposed within the lens.

Abstract: A luminaire includes a housing and a light source carried by the housing. The housing may include a first and second set of light emitting elements and a lens assembly. The lens assembly may include a lens with a first refraction section having a surface smoothness within a first range, and a second refraction section having a surface smoothness within a second range. The lens assembly may include a plurality of light source receiving members with each light source receiving member comprising a ridge. The first and second set of light emitting elements may be configured to emit light at a first and second beam angle. The light emitted by the first set and second set of light emitting elements may form a combined light with a center beam and gradient wherein the center beam has a greater candle power than the gradient.

Abstract: A luminaire including a housing and a light source carried by the housing. The housing may include a first and second set of light emitting elements and a lens assembly. The lens assembly may include a lens with a first refraction section having a surface smoothness within a first range, and a second refraction section having a surface smoothness within a second range. The lens assembly may include conical frustum light source receiving members located between the light source and the lens. The first and second set of light emitting elements is configured to emit light at a first and second beam angle. The light emitted by the first set and second set of light emitting elements form a combined light with a center beam and gradient wherein the center beam has a greater candle power than the gradient.

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: A luminaire comprising a heat sink, a light source and a light guide. The light source is carried by the heat sink and configured to emit a source light. The light source includes a heat spreader having an inner surface and an outer surface, and a plurality of light-emitting diodes (LEDs) carried by a circuit board and disposed generally along an outer peripheral perimeter portion of the inner surface of the heat spreader, and positioned in thermal communication with the heat spreader. The light guide includes a lens with a plurality of optical elements disposed within the lens.

Abstract: A luminaire with a prismatic optic permits the nearly uniform distribution of light about the luminaire. The prismatic optic permits the use of directional light sources, such as light emitting diodes, while maintaining the uniform light distribution. When light emitting diodes are used, the luminaire further includes a heat sink to maintain a desirable operational temperature without negatively affecting the light distribution properties of the luminaire.

Abstract: A luminaire for directional emission of light comprising an optic defining an optical chamber, a first plurality of light elements positioned to emit light in a first direction, defined as an upward direction, a second plurality of light elements positioned to emit light in a second direction, defined as a downward direction, and a driver circuit operably coupled to each of the first and second pluralities of light elements. The driver circuit is adapted to receive an input and is configured to operate the first and second pluralities of light elements so as to cause the luminaire to emit light in a downward distribution responsive to the input having a first configuration. Additionally, the driver circuit is configured to operate the first and second pluralities of light elements so as to cause the luminaire to emit light in an omnidirectional distribution responsive to the input having a second configuration.

Abstract: A luminaire comprising a heat sink, a light source to emit a source light, a heat spreader having inner and outer surfaces, and LEDs carried by a circuit board and disposed generally along a periphery of the inner surface and positioned in thermal communication therewith. The luminaire comprises a reflector disposed coextensively with the LEDs and comprising an aperture. An outer edge of the aperture defines an inner rim of the reflector. A light guide positioned between the reflector and the light source exhibits a height defined as the distance between the inner surface of the heat spreader and a plane defined by the inner rim of the reflector. The light guide comprises deformations and/or lens portions configured to change the source light into a shaped light that is directed through the aperture. The deformations are characterized by a common shape positioned about a center of the light guide.

Abstract: A luminaire comprising a heat sink, a light source to emit a source light, a heat spreader having inner and outer surfaces, and LEDs carried by a circuit board and disposed generally along a periphery of the inner surface and positioned in thermal communication therewith. The luminaire comprises a reflector disposed coextensively with the LEDs and comprising an aperture. An outer edge of the aperture defines an inner rim of the reflector. A light guide positioned between the reflector and the light source exhibits a height defined as the distance between the inner surface of the heat spreader and a plane defined by the inner rim of the reflector. The light guide comprises deformations and/or lens portions configured to change the source light into a shaped light that is directed through the aperture. The deformations are characterized by a common shape positioned about a center of the light guide.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: A luminaire including a housing and a light source carried by the housing. The housing may include a first and second set of light emitting elements and a lens assembly. The lens assembly may include a lens with a first refraction section having a surface smoothness within a first range, and a second refraction section having a surface smoothness within a second range. The lens assembly may include conical frustum light source receiving members located between the light source and the lens. The first and second set of light emitting elements is configured to emit light at a first and second beam angle. The light emitted by the first set and second set of light emitting elements form a combined light with a center beam and gradient wherein the center beam has a greater candle power than the gradient.

Abstract: An edge lit lighting device including a housing, a power circuit, a light source, and an optic. The power circuit may be carried by the housing, and adapted to form an electrical connection with an external power source. The light source may be carried by the housing and electrically connected to the power circuit. The optic may be carried by the housing and positioned in optical communication with the light source. The optic may further include a receiving surface positioned adjacent to the light source, and first and second emitting surfaces. The first emitting surface may include a plurality of features configured to redirect light defined as redirected light in a direction of the second emitting surface, the redirected light being emitted from the second emitting surface. The lighting device may further include pluralities of optics of light sources.

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: A luminaire comprising a heat sink, a light source carried by the heat sink to emit a source light and comprising a heat spreader having inner and outer surfaces and a plurality of LEDs carried by a circuit board and disposed generally along a periphery of the inner surface and positioned in thermal communication therewith. The luminaire comprises a reflector disposed coextensively with the LEDs and comprising an aperture in a medial region thereof, an outer edge of the aperture defining an inner rim of the reflector and a light guide positioned between the reflector and the light source, the light guide characterized by a height defined as the distance between the inner surface of the heat spreader and a plane defined by the inner rim of the reflector, the light guide configured to change the source light into a shaped light that is directed through the aperture.

Abstract: A lighting device for emitting light in selective directions including a light source structure member, a plurality of lighting devices attached to the light source structure member, a controller, a power supply, and an optic carried by the light source structure member and including a plurality of facets. Each light source of the plurality of light sources may be positioned such that light emitted thereby is emitted through a facet of the plurality of facets of the first optic. Each facet of the plurality of facets may be configured to redirect light in a direction that is unique from the other facets of the plurality of facets. Additionally, the controller may be configured to selectively operate each light source of the plurality of light sources. Multiple pairs, or combinations, of light source structure members and optics may be included.

Abstract: A light directing apparatus includes an optical substrate having first and second sides, a compound lens outer surface (CLOS) on a first portion of the first side, and first and second protrusions on a second portion of the first side. The CLOS is in optical communication with the second side, the CLOS having mirror image symmetry about a medial plane that contains a centerline of the CLOS. The first protrusion is disposed proximate the CLOS, and in optical communication with the second side. The second protrusion is disposed proximate the first protrusion, and in optical communication with the second side. The first protrusion is disposed between the second protrusion and the CLOS. The first and second protrusions each have a curved apex such that first and second planar section cuts through the optical substrate perpendicular to the medial plane cut twice through each curved apex.

Abstract: A luminaire provides light having a distribution pattern with high center beam candle power and a gradual gradient across a wide area. The luminaire includes a light source having first and second sets of light emitting elements selected and positioned to achieve the desired light distribution pattern. The luminaire further includes an optic configured to refract light emitted from the light source to achieve the desired light distribution pattern.

Abstract: A lighting device may include an electrical base, a stabilizer adapted to be matingly connected to the electrical base, a body member, and an optic connected to the body member and defining an optical chamber. A light source may be positioned within the optical chamber and in electrical communication with the electrical base. The stabilizer may be transitionable from an engaged position with the electrical base and a disengaged position with the electrical base. The disengaged position allows for the stabilizer to be translated longitudinally with respect to the base member. The engaged position slidably fixes the stabilizer with respect to the heat sink by reducing space between the electrical base, the enclosure and the heat sink.

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.