Abstract: An applicator and method for applying a microneedle array to skin. The applicator can include a body having a first portion and a second portion defining a cavity, the second portion having a slot presented on an outside surface for insertion of the microneedle array into the cavity. The first portion and the second portion are slidable relative to one other along an axis enabling the body to be in an unprimed configuration and a primed configuration. The applicator further includes a door operable with the second portion, the door being movable from a first door position to a second door position, wherein when the device is in the unprimed configuration, the door at least partially obstructs the slot and access into the cavity. When the device is in the primed configuration, the door does not obstruct the slots and enables access into the cavity.

Abstract: The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

Abstract: An applicator and method for applying a microneedle array to skin. The applicator can include a body having a first portion and a second portion defining a cavity, the second portion having a slot presented on an outside surface for insertion of the microneedle array into the cavity. The first portion and the second portion are slidable relative to one other along an axis enabling the body to be in an unprimed configuration and a primed configuration. The applicator further includes a door operable with the second portion, the door being movable from a first door position to a second door position, wherein when the device is in the unprimed configuration, the door at least partially obstructs the slot and access into the cavity. When the device is in the primed configuration, the door does not obstruct the slots and enables access into the cavity.

Abstract: An article comprising at least one microneedle is provided. The article can comprises a first side and a second side opposite the first side. The first side comprises a central cavity portion and a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface; a base segment having a base and a first shape; a tip segment having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment; and a central axis. Methods of using the article are also provided.

Abstract: An article (100) comprising at least one microneedle (160) is provided. The article comprises a first side (112) and a second side (114) opposite the first side. The first side comprises a central cavity portion (120) and a platform portion (130), with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface (163); a base segment (166) having a base (162) and a first shape; a tip segment (168) having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane (167) that delineates the base segment and the tip segment; and a central axis (180). Methods of using the article are also provided.

Abstract: An article having at least one microneedle (160, 260) is provided. The microneedle includes a base (162), an elongated body (161) having a central axis (130) and a body diameter (168), a tip portion (166), a first channel (170), and a second channel (176). The tip portion includes a tip (164), a beveled surface (140), and a bevel opening (172) in the beveled surface. The first channel extends axially from the bevel opening through at least a portion of the elongated body and has a first wall that is substantially aligned with the central axis. The second channel extends radially from the first channel to the bevel opening and has a second wall that is oriented substantially orthogonal to the central axis. The first channel and second channel merge to form the bevel opening.

Abstract: An article comprising at least one microneedle is provided. The article can comprises a first side and a second side opposite the first side. The first side comprises a central cavity portion and a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface; a base segment having a base and a first shape; a tip segment having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment; and a central axis. Methods of using the article are also provided.

Abstract: An article having at least one microneedle (160, 260) is provided. The microneedle includes a base (162), an elongated body (161) having a central axis (130) and a body diameter (168), a tip portion (166), and a hollow channel (170). The a tip portion includes a tip (164), a first bevel face (140) oriented diagonally with respect to the central axis and extending through at least 75% of the body diameter, a second bevel face (146) oriented substantially perpendicular to the central axis and intersecting the first bevel face, and a bevel opening defined by a first edge (174) of the first bevel face and a second edge (176) of the second bevel face. The hollow channel extends axially into the body from the bevel opening (172).

Abstract: An article 100 comprising at least one microneedle 160 is provided. The article comprises a first side 112 and a second side 114 opposite the first side. The first side comprises a central cavity portion 120 and a platform portion 130, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle 160 comprises a body comprising an outer surface 163; a base segment 166 having a base and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis.

Abstract: The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

Abstract: The present application provides articles (10) having a polymeric substrate (12) with a plurality of solid and/or hollow microneedles (20) extending therefrom. Each solid microneedle is formed by a molding process and the microneedle has body with first (30) and second cavities (40) extending therein. The hollow microneedles are formed by removing a portion of the polymeric material disposed between the first cavity and the second cavity. A method for determining the location of a microneedle in an article comprising solid microneedles is also provided. The method comprises directing electromagnetic radiation toward an article comprising a plurality of microneedles and imaging the article.

Abstract: An article 100 having a first side 112 that has a central portion 130 defined by a first edge 134, a microneedle-free peripheral portion 140 that substantially surrounds the central portion, and a plurality of spaced-apart hollow microneedles 160. Each microneedle has a body that includes an outer surface 163; a base segment 166 having a base 162 and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis 180. An angle, defined by an intersection of the central axis of at least one microneedle and a shortest line extending from the first edge and through the transition plane of the at least one microneedle, is less than about 50°.

Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

Abstract: An article (100) comprising at least one microneedle (160) is provided. The article comprises a first side (112) and a second side (114) opposite the first side. The first side comprises a central cavity portion (120) and a platform portion (130), with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface (163); a base segment (166) having a base (162) and a first shape; a tip segment (168) having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane (167) that delineates the base segment and the tip segment; and a central axis (180). Methods of using the article are also provided.

Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: An article having at least one microneedle (160, 260) is provided. The microneedle includes a base (162), an elongated body (161) having a central axis (130) and a body diameter (168), a tip portion (166), a first channel (170), and a second channel (176). The tip portion includes a tip (164), a beveled surface (140), and a bevel opening (172) in the beveled surface. The first channel extends axially from the bevel opening through at least a portion of the elongated body and has a first wall that is substantially aligned with the central axis. The second channel extends radially from the first channel to the bevel opening and has a second wall that is oriented substantially orthogonal to the central axis. The first channel and second channel merge to form the bevel opening.

Abstract: An article 100 comprising at least one microneedle 160 is provided. The article comprises a first side 112 and a second side 114 opposite the first side. The first side comprises a central cavity portion 120 and a platform portion 130, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle 160 comprises a body comprising an outer surface 163; a base segment 166 having a base and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis.

Abstract: An article 100 having a first side 112 that has a central portion 130 defined by a first edge 134, a microneedle-free peripheral portion 140 that substantially surrounds the central portion, and a plurality of spaced-apart hollow microneedles 160. Each microneedle has a body that includes an outer surface 163; a base segment 166 having a base 162 and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis 180. An angle, defined by an intersection of the central axis of at least one microneedle and a shortest line extending from the first edge and through the transition plane of the at least one microneedle, is less than about 50°.