Abstract: The present application provides articles (10) having a polymeric substrate (12) with a plurality of solid and/or hollow microneedles (20) extending therefrom. Each solid microneedle is formed by a molding process and the microneedle has body with first (30) and second cavities (40) extending therein. The hollow microneedles are formed by removing a portion of the polymeric material disposed between the first cavity and the second cavity. A method for determining the location of a microneedle in an article comprising solid microneedles is also provided. The method comprises directing electromagnetic radiation toward an article comprising a plurality of microneedles and imaging the article.

Abstract: A device and method for creating microchannels in the stratum corneum. The device includes a handle and a substrate detachably attached to the handle by a coupler. The substrate has a plurality of microstructures for creating microchannels in the stratum corneum. The substrate is detachable from the handle for disposal.

Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: The invention relates to devices and methods for analyzing a sample (and preferably preparing a sample), which is particularly used in analysis, such as analysis of a sample for a bacterium of interest.

Abstract: A hand-held, manually-operated sanding tool includes a base body, a handle, and a coupling device. The base body defines an aperture extending from a first surface of the base body to a second surface of the base body. The handle includes a grip and a post. The coupling device is coupled with the post of the handle through the aperture. The handle and the coupling device are positioned near opposite surfaces of the base body to rotatably couple the handle to the base body such that the handle is rotatable about an axis defined by the post.

Abstract: A hand-held, manually-operated sanding tool including a base member, a clamping mechanism, and a tab. The clamping mechanism is pivotally mounted to the base member, in alignment with a contact surface thereof such that the clamping mechanism pivots between a closed position and an open position in which a gap is defined between the clamping mechanism and the contact surface. The tab extends at least partially between the contact surface and the clamping mechanism, and establishes a stop surface that positively positions an edge of a sheet of abrasive material relative to an end of the base member as part of a loading operation.

Abstract: A hand-held, manually-operated sanding tool including a base member, a clamping mechanism, a handle and a mounting assembly. The clamping mechanism is adapted to secure a sheet-like abrasive material to the base member. The handle includes a neck and a grip. The mounting assembly rotatably mounts the handle to the base member such that the neck extends from a top surface thereof and the handle is rotatable relative to the base member about an axis defined by the neck.

Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: A hand-held, manually-operated, sanding tool that can be used with conventional rectangular or square shaped sheet-like abrasive media to sand corners or other confined areas includes a base member having at least one tapered end and includes means for securing the sheet-like abrasive media to the tool.

Abstract: A hand-held, manually-operated, sanding tool for use with a replaceable sheet-like abrasive material, such as sandpaper, includes a base member and clamping mechanisms pivotally connected with opposed ends of the base member. The clamping mechanisms include tensioning members arranged to slidably engage angled contact surfaces provided on the ends of the base member opposite the clamping mechanisms to tighten the sheet-like abrasive material as it is installed on the tool.

Abstract: A hand-held, manually-operated sanding tool for use with a replaceable sheet of abrasive material includes a base member and a clamping mechanism. The base member defines first and second ends, a bottom surface extending between the first and second ends, a contact surface formed opposite the bottom surface and extending from the first end, and at least one tooth extending from the contact surface. The clamping mechanism is pivotally connected to the base member at a pivot point, defines a front section opposite the pivot point, and is movable about the pivot point between an open position, in which the front section is spaced from the contact surface for receiving an end portion of a sheet of abrasive material, and a closed position, in which the clamping mechanism is more proximate the contact surface and the front section is more proximate the at least one tooth.

Abstract: A hand-held, manually-operated sanding tool for use with a replaceable sheet-like abrasive material, such as sandpaper, includes a base member and one or more clamping mechanisms pivotally connected with opposed ends of the base member. The clamping mechanism(s) include a tensioning member arranged to slidably interface with a corresponding contact surface provided at the end of the base member to tighten the sheet-like abrasive material as it is installed on the tool. Further, the tensioning member positions a leading edge thereof so as to minimize possible harmful contact with a user's finger(s) during loading of the abrasive material.