Abstract: Methods for repurposing a therapeutically effective amount of drugs that reduce circulating testosterone levels and/or activity (androgen-deprivation drugs) for treating, ameliorating, and/or preventing progression of dilated cardiomyopathy and heart failure. Reduction in circulating testosterone levels and/or activity is effective for treating, ameliorating, and/or preventing progression of dilated cardiomyopathy and/or heart failure in the subject.

Abstract: An engine assembly includes a small air-cooled engine and a dry sump lubrication system including an external oil reservoir, wherein the dry sump lubrication system has an overall oil capacity that provides at least five hundred hours of engine oil life.

Abstract: Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising a dimeric NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. In some embodiments, the molecule further comprises a drug moiety (e.g., an IL15/Ra moiety). The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.

Abstract: Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising a dimeric NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. In some embodiments, the molecule further comprises a drug moiety (e.g., an IL15/Ra moiety). The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.

Abstract: Aligning a motor shaft in a fan assembly is described. Aligning a centerline of a motor shaft in a direct drive fan assembly includes selecting a motor from among a plurality of motors and matching a motor-plate from among a plurality of motor plates to the motor, the matched motor plate is based on the selected motor. Aligning the centerline further includes creating, from the selected motor and the matching motor plate, a motor-plate assembly that has a resulting height, where the resulting height of the motor-plate assembly corresponds to a particular height of a direct drive fan assembly, and aligning the centerline of a motor shaft of the motor-plate assembly to the direct drive fan assembly, where the particular height of the direct drive fan assembly is constant.

Abstract: The present disclosure provides hybrid promoter sequences comprising an MND promoter and HTLV enhancer capable of driving high levels of sustained expression of a heterologous sequence in immune cells, particularly Natural Killer (NK) cells. The disclosure also provides compositions comprising such vectors, immune cells which have been genetically modified to contain the vectors, as well as methods of using the same for inducing immune responses and treating cancer and other conditions.

Abstract: Provided are NKG2D fusion proteins and their uses for the treatment of various diseases.

Abstract: An aligning device that can be mounted to a conduit for rotating the conduit in successive angular intervals. The aligning device having a bracket that can be secured to the conduit. The bracket having four bubble levels at its periphery equally spaced from each other. Each bubble level can be horizontally leveled.

Abstract: An engine assembly includes a small air-cooled engine and a dry sump lubrication system including an external oil reservoir, wherein the dry sump lubrication system has an overall oil capacity that provides at least five hundred hours of engine oil life.

Abstract: The present disclosure relates to a pharmaceutical composition comprising a STING agonist molecule in combination with an IL-15/IL-15Ra complex. The present combination can be administered independently or separately, in a quantity which is therapeutically effective for the treatment of cancer. Also provided is the use of such a combination for the manufacture of a medicament; the use of such a combination as a medicine; a kit of parts comprising such a combination; and a method of treatment of such a combination.

Abstract: Various arrangements for monitoring occupancy of multiple parking spaces are presented herein. Arrangements may use a radar-based vehicle detector that comprises a radar antenna that has a field-of-view of a portion of a parking facility. Multiple parking sensors may be present that monitor parking spaces outside of or obstructed from the field-of-view. A parking host system may be present that communicates with the radar-based vehicle detector and the plurality of parking sensors and determines in which parking space a vehicle has parked.

Abstract: Various arrangements for determining that a vehicle is present in a parking space are presented. A parking sensor can make a plurality of magnetic field strength measurements using a magnetometer. A determination that the vehicle is parked proximate to the parking sensor device within the parking space can be based on a magnetic field strength measurement in relation to the selected magnetic field strength window.

Abstract: An engine assembly includes a small air-cooled engine and a dry sump lubrication system including an external oil reservoir, wherein the dry sump lubrication system has an overall oil capacity that provides at least five hundred hours of engine oil life.

Abstract: Various embodiments of a host-neutral gateway device are presented herein. A host-neutral gateway device can include a plurality of local wireless communication interfaces that communicate with a plurality of sets of wireless devices. The host-neutral gateway device can include a plurality of long-range wireless communication interfaces that communicate with one or more remote server systems. The host-neutral gateway device can be programmed to execute a plurality operator-specific applications. Each operator-specific application may be mapped to a corresponding set of wireless devices of the plurality of sets of wireless devices.

Abstract: Methods of using measured plasma renin activity assayed (PRA), plasma renin activity concentration (PRAC), active renin concentration (ARC), plasma renin activity concentration (PRAC) and/or active plasma renin concentration (APRC), pro-renin activity, (pro)-renin receptor (PRR) levels for diagnosing, prognosing, treating and monitoring heart failure (HF) or HF-associated conditions or other conditions that cause or are caused by altered (e.g., elevated) renin activity, pro-renin levels, PRR levels, PRC, APRC, and/or interaction of renin or pro-renin with PRR. These methods can be used for at-risk patients for personalized therapy of heart disease to reduce heart dysfunction progression, diminish HF, and prolong life. This technology stratifies patients with HF or those at risk for HF to determine the appropriate medication (agents that specifically interfere with plasma renin activity/pro-renin and/or PRR) or intervention and the appropriate dosage of medication to treat further HF progression.

Abstract: Methods of utilizing quantitative magnetic resonance (QMR) to non-invasively determine and quantify body fluid dynamics [e.g., extracellular water and total water levels] and body compositions (e.g., lean muscle mass and fat mass levels). These levels or changes therein are used as biomarkers to diagnose, prognose, tailor and monitor treatment for conditions that cause or caused by ECW retention (edema), lean muscle mass loss (sarcopenia), and/or fat loss (cachexia), including heart failure (HF) and HF-associated and HF-non-associated edema/sarcopenia/cachexia, kidney disease, liver disease, and other HF complications. Body fluid dynamics and body compositions measurements obtained from QMR technology are used as biomarkers to help a physician's assessment to determine the prognosis and personalized treatment strategies that are tailored for individual patients with heart dysfunction and/or HF, HF-associated conditions, and/or other conditions that cause or caused by edema, sarcopenia, and/or cachexia.

Abstract: An aligning device that can be mounted to a conduit for rotating the conduit in successive angular intervals. The aligning device having a bracket that can be secured to the conduit. The bracket having four bubble levels at its periphery equally spaced from each other. Each bubble level can be horizontally leveled.

Abstract: Various arrangements for monitoring occupancy of multiple parking spaces are presented herein. Arrangements may use a radar-based vehicle detector that comprises a radar antenna that has a field-of-view of a portion of a parking facility. Multiple parking sensors may be present that monitor parking spaces outside of or obstructed from the field-of-view. A parking host system may be present that communicates with the radar-based vehicle detector and the plurality of parking sensors and determines in which parking space a vehicle has parked.

Abstract: Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising a dimeric NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. In some embodiments, the molecule further comprises a drug moiety (e.g., an IL15/Ra moiety). The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.

Abstract: Various arrangements for monitoring occupancy of multiple parking spaces are presented herein. Arrangements may use a radar-based vehicle detector that comprises a radar antenna that has a field-of-view of a portion of a parking facility. Multiple parking sensors may be present that monitor parking spaces outside of or obstructed from the field-of-view. A parking host system may be present that communicates with the radar-based vehicle detector and the plurality of parking sensors and determines in which parking space a vehicle has parked.