Abstract: Provided are compositions and methods for transducing immune cells in vivo where a viral particle comprising a polynucleotide encoding a chimeric antigen receptor and a multipartite cell-surface receptor is administered to a subject.

Abstract: Methods, systems, and devices are described for providing network access services to mobile users via mobile terminals over a satellite system. In embodiments, dynamic multiplexing of traffic from fixed terminals and mobile users on the same satellite beam can take advantage of statistical multiplexing of large numbers of users and on different usage patterns between fixed terminals and mobile users. In embodiments, quality-of-service (QoS) is controlled for mobile devices at a per-user level. Mobile users may be provisioned on the satellite system according to a set of traffic policies based on their service level agreement (SLA). System resources of the satellite may be allocated to mobile users based on the demand of each mobile user and the set of traffic polices associated with each mobile user, regardless of which mobile terminal is used to access the system.

Abstract: Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising a dimeric NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. In some embodiments, the molecule further comprises a drug moiety (e.g., an IL15/Ra moiety). The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.

Abstract: Aligning a motor shaft in a fan assembly is described. Aligning a centerline of a motor shaft in a direct drive fan assembly includes selecting a motor from among a plurality of motors and matching a motor-plate from among a plurality of motor plates to the motor, the matched motor plate is based on the selected motor. Aligning the centerline further includes creating, from the selected motor and the matching motor plate, a motor-plate assembly that has a resulting height, where the resulting height of the motor-plate assembly corresponds to a particular height of a direct drive fan assembly, and aligning the centerline of a motor shaft of the motor-plate assembly to the direct drive fan assembly, where the particular height of the direct drive fan assembly is constant.

Abstract: The present disclosure provides hybrid promoter sequences comprising an MND promoter and HTLV enhancer capable of driving high levels of sustained expression of a heterologous sequence in immune cells, particularly Natural Killer (NK) cells. The disclosure also provides compositions comprising such vectors, immune cells which have been genetically modified to contain the vectors, as well as methods of using the same for inducing immune responses and treating cancer and other conditions.

Abstract: A method of operating a fan for an air-cooled internal combustion engine includes starting the air-cooled internal combustion engine, operating the fan in a first operating mode in which the fan rotates in a first direction, and operating the fan in a second operating mode in which the fan rotates in a second direction.

Abstract: The devices and methods described herein integrate security and/or recording mechanisms into unmanned vehicle interdiction devices to prevent unauthorized use and to record information related to operation of the unmanned vehicle interdiction device, identification of an unmanned vehicle, location of the unmanned vehicle, and operation of the unmanned vehicle.

Abstract: Several examples of a navigation disruption device and methods of using the same are described herein that use real-time, low-cost computation to generate conflicting/competing signals to actual Global Navigation Satellite System (GNSS) signals. For example, the novel, hand-held navigation disruption devices described herein (1) generate signals from a simulated satellite constellation, wherein the signals from the simulated satellite constellation conflict/compete with signals from one or more actual satellite constellations, and (2) transmit the signals from the simulated satellite constellation(s) towards an unmanned vehicle. The signals from the simulated satellite constellation(s) cause the unmanned vehicle to compute an incorrect position, which in turn disrupts its ability to navigate and operate effectively.

Abstract: An air-cooled internal combustion engine including a crankshaft rotating about a crankshaft axis, a first cylinder having a first cylinder head, a second cylinder having a second cylinder head, and a blower assembly. The blower assembly includes a blower housing, a first fan, and a second fan. The first fan is positioned proximate the first cylinder and the second fan is positioned proximate the second cylinder. The first fan and the second fan are each received within the blower housing.

Abstract: Several examples of a dual remote control and crew-served weapon station are described herein that uniquely provide different operating modes, any one of which can be quickly and efficiently selected based on outputs from various system sensors (e.g., switches and buttons). For example, a first operating mode is a mode in which the weapon is remotely steered and fired (e.g., remote controlled). A second operating mode is a mode in which a weapon cradle is stabilized by a gimbal and the weapon is aimed and fired by a local operator (e.g., crew-served stabilized). A third operating mode is a mode in which the cradle is manually steered and the weapon is fired by the local operator (e.g., full manual).

Abstract: Provided are NKG2D fusion proteins and their uses for the treatment of various diseases.

Abstract: An aligning device that can be mounted to a conduit for rotating the conduit in successive angular intervals. The aligning device having a bracket that can be secured to the conduit. The bracket having four bubble levels at its periphery equally spaced from each other. Each bubble level can be horizontally leveled.

Abstract: An air-cooled internal combustion engine including a crankshaft rotating about a crankshaft axis, a first cylinder having a first cylinder head, a second cylinder having a second cylinder head, and a blower assembly. The blower assembly includes a blower housing, a first fan, and a second fan. The first fan is positioned proximate the first cylinder and the second fan is positioned proximate the second cylinder. The first fan and the second fan are each received within the blower housing.

Abstract: An engine assembly includes a small air-cooled engine and a dry sump lubrication system including an external oil reservoir, wherein the dry sump lubrication system has an overall oil capacity that provides at least five hundred hours of engine oil life.

Abstract: The present disclosure relates to a pharmaceutical composition comprising a STING agonist molecule in combination with an IL-15/IL-15Ra complex. The present combination can be administered independently or separately, in a quantity which is therapeutically effective for the treatment of cancer. Also provided is the use of such a combination for the manufacture of a medicament; the use of such a combination as a medicine; a kit of parts comprising such a combination; and a method of treatment of such a combination.

Abstract: An air-cooled internal combustion engine including a crankshaft rotating about a crankshaft axis, a first cylinder having a first cylinder head, a second cylinder having a second cylinder head, and a blower assembly. The blower assembly includes a blower housing, a first fan, and a second fan. The first fan is positioned proximate the first cylinder and the second fan is positioned proximate the second cylinder.

Abstract: Various arrangements for monitoring occupancy of multiple parking spaces are presented herein. Arrangements may use a radar-based vehicle detector that comprises a radar antenna that has a field-of-view of a portion of a parking facility. Multiple parking sensors may be present that monitor parking spaces outside of or obstructed from the field-of-view. A parking host system may be present that communicates with the radar-based vehicle detector and the plurality of parking sensors and determines in which parking space a vehicle has parked.

Abstract: Various arrangements for determining that a vehicle is present in a parking space are presented. A parking sensor can make a plurality of magnetic field strength measurements using a magnetometer. A determination that the vehicle is parked proximate to the parking sensor device within the parking space can be based on a magnetic field strength measurement in relation to the selected magnetic field strength window.

Abstract: An engine assembly includes a small air-cooled engine and a dry sump lubrication system including an external oil reservoir, wherein the dry sump lubrication system has an overall oil capacity that provides at least five hundred hours of engine oil life.

Abstract: Various embodiments of a host-neutral gateway device are presented herein. A host-neutral gateway device can include a plurality of local wireless communication interfaces that communicate with a plurality of sets of wireless devices. The host-neutral gateway device can include a plurality of long-range wireless communication interfaces that communicate with one or more remote server systems. The host-neutral gateway device can be programmed to execute a plurality operator-specific applications. Each operator-specific application may be mapped to a corresponding set of wireless devices of the plurality of sets of wireless devices.