Patents by Inventor Ryu Hirata
Ryu Hirata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11534404Abstract: Multilayer beads for pharmaceutical use having a drug-in-polymer layer are disclosed. The disclosed multilayer beads for pharmaceutical use have (a) a core particle; (b) an optional barrier layer coated on the surface of the core particle; (c) a drug-in-polymer layer coated on the surface of the core or the barrier layer, (d) an optional sealant layer coated on the surface of the drug-in-polymer layer; and (e) optionally one or more outer layers external to the drug-in-polymer layer or the sealant layer. The drug-in-polymer layer consists essentially of (i) a drug selected from the group consisting of a 15-keto prostaglandin drug, a 13,14-dihydro prostaglandin drug, and a 13,14-dihydro-15-keto prostaglandin drug; and (ii) a polymer selected from the group consisting of polyvinylpyrrolidone, vinylpyrrolidone-vinylacetate copolymer or a mixture thereof. The drug-in-polymer layer may be solid dispersion of the drug in the polymer.Type: GrantFiled: October 5, 2017Date of Patent: December 27, 2022Assignee: Sucampo AGInventors: Deepak Tiwari, Yasuhiro Harada, Ryu Hirata
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Publication number: 20200390708Abstract: Multilayer beads for pharmaceutical use having a drug-in-polymer layer are disclosed. The disclosed multilayer beads for pharmaceutical use have (a) a core particle; (b) an optional barrier layer coated on the surface of the core particle; (c) a drug-in-polymer layer coated on the surface of the core or the barrier layer, (d) an optional sealant layer coated on the surface of the drug-in-polymer layer; and (e) optionally one or more outer layers external to the drug-in-polymer layer or the sealant layer. The drug-in-polymer layer consists essentially of (i) a drug selected from the group consisting of a 15-keto prostaglandin drug, a 13,14-dihydro prostaglandin drug, and a 13,14-dihydro-15-keto prostaglandin drug; and (ii) a polymer selected from the group consisting of polyvinylpyrrolidone, vinylpyrrolidone-vinylacetate copolymer or a mixture thereof. The drug-in-polymer layer may be solid dispersion of the drug in the polymer.Type: ApplicationFiled: October 5, 2017Publication date: December 17, 2020Inventors: Deepak Tiwari, Yasuhiro Harada, Ryu Hirata
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Patent number: 10868319Abstract: An air cleaner for a fuel cell vehicle includes: a case having an inlet and an outlet; and a filter element fixed to the case, the filter element being configured to section the case into an inlet side and an outlet side and filter air flowing from the inlet side to the outlet side. A locking projection projecting toward the inside of the case is provided on the inlet side in the case. A first prefilter, a second prefilter, and a chemical filter are sandwiched between the locking projection and the filter element in the order of the first prefilter, the chemical filter, and the second prefilter from the upstream side as the inlet side of the filter element inside the case toward the downstream side as the outlet side of the filter element inside the case.Type: GrantFiled: November 20, 2018Date of Patent: December 15, 2020Assignees: Toyota Jidosha Kabushiki Kaisha, Toyota Boshoku Kabushiki KaishaInventors: Tetsuya Ichikawa, Kimiko Yoshida, Jun Goto, Ryu Hirata, Noriaki Miki
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Publication number: 20190181479Abstract: An air cleaner for a fuel cell vehicle includes: a case having an inlet and an outlet; and a filter element fixed to the case, the filter element being configured to section the case into an inlet side and an outlet side and filter air flowing from the inlet side to the outlet side. A locking projection projecting toward the inside of the case is provided on the inlet side in the case. A first prefilter, a second prefilter, and a chemical filter are sandwiched between the locking projection and the filter element in the order of the first prefilter, the chemical filter, and the second prefilter from the upstream side as the inlet side of the filter element inside the case toward the downstream side as the outlet side of the filter element inside the case.Type: ApplicationFiled: November 20, 2018Publication date: June 13, 2019Applicants: Toyota Jidosha Kabushiki Kaisha, Toyota Boshoku Kabushiki KaishaInventors: Tetsuya Ichikawa, Kimiko Yoshida, Jun Goto, Ryu Hirata, Noriaki Miki
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Publication number: 20170020890Abstract: An oral pharmaceutical composition comprising (a) a specific fatty acid derivative, (b) a specific sweetening agent and (c) a pharmaceutically acceptable oily vehicle, and an oily liquid formulation comprising thereof is provided.Type: ApplicationFiled: June 16, 2016Publication date: January 26, 2017Inventors: Ryuji UENO, Ryu HIRATA, Yasuhiro HARADA, Tomoko TSUDA
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Publication number: 20140287036Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.Type: ApplicationFiled: June 10, 2014Publication date: September 25, 2014Applicants: R-TECH UENO, LTD., SUCAMPO AGInventors: Yukiko HASHITERA, Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
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Patent number: 8779187Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.Type: GrantFiled: November 16, 2012Date of Patent: July 15, 2014Assignees: Sumcampo AG, R-Tech Ueno, Ltd.Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
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Patent number: 8669284Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.Type: GrantFiled: June 15, 2011Date of Patent: March 11, 2014Assignees: Sucampo AG, R-Tech Ueno, Ltd.Inventors: Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
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Patent number: 8389748Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.Type: GrantFiled: April 19, 2010Date of Patent: March 5, 2013Assignees: Sucampo AG, R-Tech Ueno, Ltd.Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
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Patent number: 8338639Abstract: The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.Type: GrantFiled: August 16, 2011Date of Patent: December 25, 2012Assignees: Sucampo AG, R-Tech Ueno, Ltd.Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
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Patent number: 8304562Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.Type: GrantFiled: April 19, 2010Date of Patent: November 6, 2012Assignees: Sucampo AG, R-Tech Ueno, Ltd.Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
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Patent number: 8236969Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.Type: GrantFiled: April 19, 2010Date of Patent: August 7, 2012Assignees: Sucampo AG, R-Tech Ueno, Ltd.Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
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Patent number: 8082906Abstract: An air duct 13 connected to the intake system of an engine 12 has a duct main body 13A and a cylindrical fuel adsorption filter 19 having air permeability. The fuel adsorption filter 19 is located in the duct main body 13A. The fuel adsorption filter 19 is arranged to be coaxial with respect to the duct main body 13A. A gap 21 is defined between the inner circumferential surface of the duct main body 13A and the outer circumferential surface of the fuel adsorption filter 19. An opening 22 for drawing air flow into the gap 21 is formed between an air flow upstream side of the gap 21 and an air passage area of the duct main body 13A.Type: GrantFiled: December 5, 2008Date of Patent: December 27, 2011Assignee: Toyota Boshoku Kabushiki KaishaInventors: Ryu Hirata, Yoshinobu Nagasaka, Hirotsugu Kojima
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Publication number: 20110300211Abstract: The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.Type: ApplicationFiled: August 16, 2011Publication date: December 8, 2011Applicants: SUCAMPO AG, R-TECH UENO, LTD.Inventors: Yukiko HASHITERA, Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
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Publication number: 20110244036Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.Type: ApplicationFiled: June 15, 2011Publication date: October 6, 2011Applicants: SUCAMPO AG, R-TECH UENO, LTD.Inventors: Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
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Publication number: 20110244037Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.Type: ApplicationFiled: June 15, 2011Publication date: October 6, 2011Applicants: SUCAMPO AG, R-TECH UENO, LTD.Inventors: Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
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Patent number: 8026393Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.Type: GrantFiled: January 23, 2007Date of Patent: September 27, 2011Assignees: Sucampo AG, R-Tech Ueno, Ltd.Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
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Patent number: 7985770Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (i): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.Type: GrantFiled: January 23, 2007Date of Patent: July 26, 2011Assignees: Sucampo AG, R-Tech Ueno, Ltd.Inventors: Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
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Publication number: 20100274032Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.Type: ApplicationFiled: April 19, 2010Publication date: October 28, 2010Applicants: SUCAMPO AG, R-TECH UENO, LTD.Inventors: Ryu HIRATA, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
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Patent number: 7811350Abstract: A sheet-like filter element is installed on a support within the casing of a filter device. A plate-like portion is integrally formed in at least the outer periphery of the filter element. A crimped portion which is to be secured to the support in a crimped state is formed in this plate-like portion. A protrusion which rises through the above described plate-like portion is formed so as to be integrated with the above described support around this crimped portion. The plate-like portion is secured to the support by means of this protrusion.Type: GrantFiled: December 19, 2007Date of Patent: October 12, 2010Assignee: Toyota Boshoku Kabushiki KaishaInventors: Ryu Hirata, Kouichi Oda