Patents by Inventor Ryuji Ueno

Ryuji Ueno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostaglandins of the D series, and tranquilizers and soporifics containing the same
    Patent number: 5534547
    Abstract: The present invention provides novel prostaglandins D, that is, 13,14-dihydro-15-keto-PGDs, whieh have an excellent sedative and sleep-inducing activity, and so they are useful for tranquilizer and/or soporifics.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: July 9, 1996
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
  • Stabilization of a prostanoic acid compound
    Patent number: 5523461
    Abstract: The present invention provides a method of stabilizing a prostanoic acid compound, wherein the prostanoic acid compound having at least one oxo group on the .omega. chain are stored in a hydrous condition.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: June 4, 1996
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Ryuji Ueno, Ryu Hirata
  • Method of producing .alpha., .beta.-unsaturated ketones
    Patent number: 5468880
    Abstract: Improvement in the technique of synthesizing prostaglandins, particularly those having at least one halogen atom at the 16- or 17-position, which comprises introducing a .omega. chain into the aldehyde thereby to enable considerable yield improvement in the production of .alpha.,.beta.-unsaturated ketones, and which does not involve hydrogen generation and can insure safe operation.A method of producing .alpha.,.beta.-unsaturated ketones by reacting aldehyde with 2-oxoalkyl phosphonate, wherein the reaction was carried out under the presence of a base and a zinc compound.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: November 21, 1995
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Tomio Oda
  • Treatment of ocular hypertension
    Patent number: 5432174
    Abstract: A method for the treatment of ocular hypertension which comprises administering, to a subject in need of such treatment,(a) a .beta.-adrenergic blocker at the enhancement phase of aqueous humor production, and(b) a prostanoic acid compound at the suppression phase of aqueous humor production, andin an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: December 7, 1993
    Date of Patent: July 11, 1995
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Ryuji Ueno, Sachiko Kuno
  • Prostaglandins E and anti ulcers containing same
    Patent number: 5428062
    Abstract: The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E.Therefore, the novel 13,14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.
    Type: Grant
    Filed: April 28, 1993
    Date of Patent: June 27, 1995
    Assignee: K.K. Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
  • Use of 15-keto-prostaglandin compound for improvement of encephalic function
    Patent number: 5426115
    Abstract: A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for improvement of encephalic function.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: June 20, 1995
    Assignee: Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Hiroyoshi Osama, Tomio Oda
  • Treatment of ocular hypertension with a synergistic combination
    Patent number: 5405846
    Abstract: A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an ocular-hypertension synergistic combination of(a) a 15-deoxy-prostaglandin compound, and(b) a .beta.-adrenergic blocker in an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: April 11, 1995
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno
  • Treatment of ocular hypertension with an ocular synergistic combination
    Patent number: 5397797
    Abstract: A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, a oculo-hypotensively synergistic combination of(a) a 13,14-dihydro-15-ketoprostaglandin compound, and(b) a cholinergic agentin an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: March 14, 1995
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno
  • Prostaglandins E and anti ulcers containing same
    Patent number: 5380709
    Abstract: The novel 13, 14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto prostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E. Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.
    Type: Grant
    Filed: April 28, 1993
    Date of Patent: January 10, 1995
    Assignee: K.K. Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
  • Tracheobronchodilator using 16-substituted PGEs
    Patent number: 5362751
    Abstract: The present invention provides a tracheobronchodilator comprising 15-keto-PGEs, reduced in stimuli against bronchi and other side effects.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: November 8, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
  • Treatment of inflammation with 15-keto-prostaglandin compounds
    Patent number: 5346921
    Abstract: A method of treatment of inflammatory diseases which comprises administering, to a subject in need of such treatment, an anti-inflammatorily effective amount of a 15-keto-prostaglandin compound.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: September 13, 1994
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno
  • Prostaglandin cathartic
    Patent number: 5317032
    Abstract: The present invention relates to cathartics comprising 15-keto-16-halogen-PGs as an essential ingredient without substantive side-effects; the catharic effect is thought mainly caused by an enteropooling effect.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: May 31, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Sachiko Kuno, Tomio Oda
  • Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds
    Patent number: 5302617
    Abstract: A method for treatment of an allergic disease which comprises administering, to a subject in need of such treatment, a 15-dehydroxy-16-oxoprostaglandin compound in an amount effective in treatment of the allergic disease
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: April 12, 1994
    Assignee: Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio
    Inventor: Ryuji Ueno
  • Use of 15-keto-prostaglandin compound for improvement of encephalic function
    Patent number: 5290811
    Abstract: A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for improvement of encephalic function.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: March 1, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Hiroyoshi Osama, Tomio Oda
  • Prostaglandins E and anti ulcers containing same
    Patent number: 5284858
    Abstract: The novel 13, 14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-ketoprostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E.Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: February 8, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
  • Process for production of prostaglandin intermediates
    Patent number: 5274130
    Abstract: The isomer ratio of a cis-isomer against the corresponding trans-isomer with respect to the 5-6 double bond is improved in the production of prostaglandins, when a lactol is reacted with an ylide to cause simultaneously formation of the 5-double bond and an .alpha.-chain, whereby the ylide generated from a phosphonium salt with a potossium base, and a solvent which is liquid at the reaction temperature and has a dipole moment of 0.3 to 3.0D are used.
    Type: Grant
    Filed: September 1, 1992
    Date of Patent: December 28, 1993
    Assignee: R-Tech Ueno Ltd.
    Inventors: Ryuji Ueno, Tomio Oda
  • Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds
    Patent number: 5256696
    Abstract: A method for treatment of a cardiac dysfunction which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of the cardiac dysfunction.
    Type: Grant
    Filed: June 2, 1992
    Date of Patent: October 26, 1993
    Assignee: Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Hiroyoshi Osama
  • Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds
    Patent number: 5254588
    Abstract: A method for treatment of a pulmonary dysfunction which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of the pulmonary dysfunction.
    Type: Grant
    Filed: June 2, 1992
    Date of Patent: October 19, 1993
    Assignee: KabushikiKaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Hiroyoshi Osama
  • Promotion of wound-healing with 15-keto-prostaglandin compounds
    Patent number: 5252605
    Abstract: A method for promoting healing of wound which comprises administering, to a subject in need of such treatment, a wound-healingly effective amount of a 15-ketoprostaglandin compound.
    Type: Grant
    Filed: March 12, 1992
    Date of Patent: October 12, 1993
    Assignee: R-Tech Ueno Ltd.
    Inventor: Ryuji Ueno
  • Excretion of potassium ion by prostanoic acid derivatives
    Patent number: RE34756
    Abstract: Amethod for inducing decrease in potassium ion concentration in the blood which comprises administering, to a subject having an increased potassium ion concentration in the blood, a prostanoic acid derivative in an amount effective in inducing decrease in potassium ion concentration in the blood wherein said concentration is increased or for improving extracorporeal excretion of potassium ion in the blood which comprises administering, to a subject having an increased potassium ion concentration in the blood, a prostanoic acid derivative in an amount effective in improving extracorporeal excretion of potassium ion concentration is increased.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: October 11, 1994
    Assignee: Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Hiroyoshi Osama