Abstract: The technology disclosed relates to a variant pathogenicity classifier. The variant pathogenicity classifier comprises memory and runtime logic. The memory stores (i) a reference amino acid sequence of a protein, (ii) an alternative amino acid sequence of the protein that contains a variant amino acid caused by a variant nucleotide, and (iii) a protein contact map of the protein. The runtime logic has access to the memory, and is configured to provide (i) the reference amino acid sequence, (ii) the alternative amino acid sequence, and (iii) the protein contact map as input to a first neural network, and to cause the first neural network to generate a pathogenicity indication of the variant amino acid as output in response to processing (i) the reference amino acid sequence, (ii) the alternative amino acid sequence, and (iii) the protein contact map.

Abstract: The technology disclosed relates to a variant pathogenicity prediction network. The variant pathogenicity classifier includes memory, a variant encoding sub-network, a protein contact map generation sub-network, and a pathogenicity scoring sub-network. The memory stores a reference amino acid sequence of a protein, and an alternative amino acid sequence of the protein that contains a variant amino acid caused by a variant nucleotide. The variant encoding sub-network is configured to process the alternative amino acid sequence, and generate a processed representation of the alternative amino acid sequence. The protein contact map generation sub-network is configured to process the reference amino acid sequence and the processed representation of the alternative amino acid sequence, and generate a protein contact map of the protein. The pathogenicity scoring sub-network is configured to process the protein contact map, and generate a pathogenicity indication of the variant amino acid.

Abstract: A system executes an enterprise framework for enterprise-wide software monitoring using a Software Deployment Management (SDM) environment such as Pega®. The system accesses a plurality of virtual machines running within the enterprise; determine a plurality of applications running in each of the plurality of virtual machines; access each of the management beans provided by each of the plurality of applications in each of the plurality of virtual machines; identify each of the management beans by name and operation; parse each of the management beans to determine associated automated entity (i.e., agent and/or listener) information; and store the automated entity information in an accessible database. Each of the management beans may be accessed periodically and based on a predetermined regular time interval and/or may be accessed substantially concurrently. Likewise, each of the virtual machines may be accessed substantially concurrently. The time of access may also be stored.

Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.

Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.

Abstract: In one embodiment, a processor includes a frontend unit having an instruction decoder to receive and to decode instructions of a plurality of threads, an execution unit coupled to the instruction decoder to receive and execute the decoded instructions, and an instruction retirement unit having a retirement logic to receive the instructions from the execution unit and to retire the instructions associated with one or more of the threads that have an instruction or an event pending to be retired. The instruction retirement unit includes a thread arbitration logic to select one of the threads at a time and to dispatch the selected thread to the retirement logic for retirement processing.

Abstract: An automated security provisioning protocol is provided for wide area network communication devices in an open device environment, such as cellular communication devices in a machine-to-machine (M2M) environment. For example, a method for performing a security provisioning protocol between a first communication device and a second communication device over at least one wide area communication network comprises the following steps from the perspective of the first communication device. The first communication device automatically uses access information not previously provisioned in the wide area communication network to gain access to the wide area communication network for an initial purpose of communicating with the second communication device.

Abstract: A method for intercepting encrypted communications exchanged between first and second computing devices in a communication network, wherein interception is performed by a third computing device in the computing network. The third computing device obtains one or more packets having a packet address associated with one of the first and second computing devices in response to at least one interception routing policy being implemented in at least one element in the communication network, such that the obtained packets may be decrypted to obtain data contained therein. The third computing device preserves the packet address of the obtained packets and forwards the obtained packets toward a packet-destination one of the first and second computing devices such that the packet-destination one of the first and second computing devices is unable to detect from the one or more packets that the one or more packets were intercepted by the third computing device.

Abstract: Automated secure registration techniques for communication devices are provided which address the problem of allowing multiple clients to gain access to one system, and thus provide a solution to the “reverse single sign-on” problem. For example, a method for registering a group of two or more communication devices in a communication network comprises the following steps. A group challenge message is sent from a network device to the group of two or more communication devices. The network device receives one or more response messages to the group challenge respectively from one or more of the group of two or more communication devices, wherein the response message from each of the responding communication devices in the group comprises a group credential corresponding to the group.

Abstract: A hard, transparent coating for a substrate and associated method for coating is disclosed. The coating includes alternating layers of a soft coating and a hard coating. The coating further includes a sensor. The electrical resistivity of the sensor may be measured to determine if the coating has been degraded. The coating may further include a hydrophobic outer layer.

Abstract: An exemplary embodiment provides coated polymeric substrates that have a polymeric substrate body with a coated surface. The surface coating includes more than one pair of coating layers. Each pair of coating layers includes a first applied coating layer and a second applied coating layer. In addition, an indicator, applied on top of or between coating layers, provides an indication of wear of the coating. The first and second applied coating layers have a thickness between about 3 to about 10 nanometers. The coating exhibits a Hall-Petch effect.

Abstract: In one embodiment, a processor includes a frontend unit having an instruction decoder to receive and to decode instructions of a plurality of threads, an execution unit coupled to the instruction decoder to receive and execute the decoded instructions, and an instruction retirement unit having a retirement logic to receive the instructions from the execution unit and to retire the instructions associated with one or more of the threads that have an instruction or an event pending to be retired. The instruction retirement unit includes a thread arbitration logic to select one of the threads at a time and to dispatch the selected thread to the retirement logic for retirement processing.

Abstract: A method for securing at least one message transferred in a communication system from a first computing device to a second computing device in a peer-to-peer manner. At the first computing device, an identity based authenticated key exchange session is established with a third computing device operating as a peer authenticator. The identity based authenticated key exchange session has an identity based authenticated session key associated therewith. The first computing device obtains from the third computing device a random key component of the second computing device, wherein the random key component of the second computing device is encrypted by the third computing device using the identity based authenticated session key prior to sending the random key component of the second computing device to the first computing device. A peer-to-peer messaging key is computed at the first computing device using the random key component of the second computing device.

Abstract: A key agreement protocol between a first party and a second party comprises the following steps from the first party perspective. An encrypted first random key component is directed to the second party, the first random key component having been computed at the first party and encrypted using a public key of the second party in accordance with an identity based encryption operation. An encrypted second random key component corresponding to the second party is received. The encrypted second random key component is decrypted using a private key of the first party. A session key for use in subsequent communications between the first party and the second party is computed based at least in part on the second random key component.

Abstract: A method for managing a conference between two or more parties comprises an identity based authenticated key exchange between a conference management element and each of the two or more parties seeking to participate in the conference. Messages exchanged between the conference management element and the two or more parties are encrypted based on respective identities of recipients of the messages. The method comprises the conference management element receiving from each party a random group key component. The random group key component is computed by each party based on a random number used by the party during the key authentication operation and random key components computed by a subset of others of the two or more parties seeking to participate in the conference. The conference management element sends to each party the random group key components computed by the parties such that each party can compute the same group key.

Abstract: A hybrid coating composition including an organosilane component, a metal alkoxide component and a surfactant component, with the metal alkoxide component present in the composition at a molar ratio of about 75:1 with respect to the surfactant component. The hybrid coating composition once cured on a transparent substrate has an initial clarity greater than 98. Transparent members are also disclosed that include a transparent substrate having the hybrid coating composition cured on a first major surface thereof.

Abstract: A coating and associated method for coating is disclosed. The coating provides a hard, transparent, UV blocking coating for a substrate. A UV blocking layer is first deposited upon the substrate, and a hard coating is deposited above the UV blocking layer. A soft coating layer may be deposited between the UV blocking layer and the hard coating. The soft and hard coating layers may both have the general composition SiOxCy. the soft and hard coating layers may be deposited by a plasma vapor deposition process.

Abstract: A single instance of a session key generation protocol is executed in a manner that generates a plurality of security associations between user equipment and a first network element of a communication system. In one aspect, a first one of the security associations is utilized to secure data sent between the user equipment and the first network element in an ongoing communication. In conjunction with a handoff of the ongoing communication from the first network element to a second network element of the communication system, another one of the security associations is selected, and the other selected security association is utilized to secure data sent between the user equipment and the second network element in the ongoing communication. The security associations may comprise respective sets of session keys derived from a single pairwise master key.

Abstract: A hard, transparent coating for a substrate and associated method for coating is disclosed. The coating includes alternating layers of a soft coating and a hard coating. The coating further includes a sensor. The electrical resistivity of the sensor may be measured to determine if the coating has been degraded. The coating may further include a hydrophobic outer layer.

Abstract: Principles of the invention provide one or more secure key management protocols for use in communication environments such as a media plane of a multimedia communication system. For example, a method for performing an authenticated key agreement protocol, in accordance with a multimedia communication system, between a first party and a second party comprises, at the first party, the following steps. Note that encryption/decryption is performed in accordance with an identity based encryption operation. At least one private key for the first party is obtained from a key service. A first message comprising an encrypted first random key component is sent from the first party to the second party, the first random key component having been computed at the first party, and the first message having been encrypted using a public key of the second party.