Abstract: Provided are antibodies that bind to interleukin-18 binding protein (IL-18BP) and related compositions, which may be used in any of a variety of therapeutic or diagnostic methods, including the treatment or diagnosis of cancers and other diseases.

Abstract: A gate valve comprises a valve body including a cavity and a flow bore with a flow axis. A gate in the cavity is movable along a stem axis between an open and closed position. A first seat is in a first pocket of the body on one side of the gate. An upstream seal is disposed between upstream opposing faces of the first seat and the first pocket, these upstream opposing faces being parallel to the bore axis, and the upstream seal is configured to prevent fluid moving axially from the flow bore toward the gate. A downstream seal is disposed between downstream opposing faces of the first seat and the first pocket, these downstream opposing faces being perpendicular to the bore axis, and the downstream seal is configured to prevent fluid moving from the cavity toward the flow bore in a direction perpendicular to the bore axis.

Abstract: Metal oxide-polymer composite particles have a median particle size D50 of 40-75 nm or 100-150 nm and an average RTA of at least 0.06. Alternatively or in addition, metal oxide-polymer composites comprise two or more populations of metal oxide particles differing in size, particle size distribution, or shape. Alternatively or in addition, the use of a multicomponent hydrophobizing system including an alkylsilane to fabricate metal oxide-polymer composite particles increases the tribocharge of the composite particles.

Abstract: A mixing system for pigment dispersions, colorants, paints, and coatings, including a mixing or dispersion blade having a disc having top and bottom surfaces and an outboard edge, vanes circumferentially spaced around and extending from the outboard edge of the disc, each vane oriented non-horizontal to the top surface of the disc, and a wear-indicating notch in at least one of the vanes; and a tank, the tank including a paint, pigment dispersion, colorant, or coating.

Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples such that, once a certain bacterial concentration is achieved, the higher concentration sample can be used with a mass spectrometer to identify the type of bacteria. The instrument and mass spectrometer can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

Abstract: An aftertreatment system for treating exhaust gas includes: an exhaust conduit configured to receive the exhaust gas; a preheating oxidation catalyst disposed in the exhaust conduit; a primary oxidation catalyst disposed in the exhaust conduit downstream of the preheating oxidation catalyst; a selective catalytic reduction system disposed in the exhaust conduit downstream of the primary oxidation catalyst; and a controller configured to: determine a temperature of the exhaust gas at an inlet of the selective catalytic reduction system, and in response to the temperature of the exhaust gas at the inlet of the selective catalytic reduction system being below a threshold temperature, cause hydrocarbons to be provided to the preheating oxidation catalyst or to the exhaust conduit at a location upstream of the preheating oxidation catalyst. The preheating oxidation catalyst catalyzes combustion of the hydrocarbons so as to increase the temperature of the exhaust gas to above the threshold temperature.

Abstract: A method for installing an automation panel at a building includes configuring, prior to shipping the automation panel to the building, a cellular modem of the automation panel to provide an association of the cellular modem with the building, establishing, upon physical installation of the automation panel at the building, a connection between the automation panel and a remote application based on the association of the cellular modem with the building, and commissioning, by the remote application via the connection, the automation panel.

Abstract: Dynamically resizable UI views for electronic devices are disclosed. The dynamically resizable UI views may be UI views for widgets. In one or more implementations, an application provides, to a system process, multiple states for a user interface (UI) view for the application, and one or more transition definitions each defining a transition between two of the multiple states. When a user, or content of the UI view, triggers a change from one of the multiples states to another of the multiple states of the UI view, the system process may animate the change according to the one or more transition definitions. In one or more implementations, an application provides system animated transitions between application UI States, and provides application data to be displayed in the rendered UI view.

Abstract: Condition-based, selective workload reduction through at least one port of a network device is provided. The process includes determining, by a network device of a computing environment, that the network device has a defined condition, and obtaining, by the network device, classifications of applications using the network device, where the classifications include multiple different application classifications. Further, the process includes reducing, by the network device, workload through at least one port of the network device based on determining that the network device has the defined condition. The reducing includes reducing workload through the at least one port of the network device of an application of a particular application classification of the multiple different application classifications, without reducing workload through a selected port of the network device of another application of a different application classification of the multiple different application classifications.

Abstract: Methods and apparatuses provide improved navigation through tubular networks such as lung airways by providing improved estimation of location and orientation information of a medical instrument (e.g., an endoscope) within the tubular network. Various input data such as image data, EM data, and robot data are used by different algorithms to estimate the state of the medical instrument, and the state information is used to locate a specific site within a tubular network and/or to determine navigation information for what positions/orientations the medical instrument should travel through to arrive at the specific site. Probability distributions together with confidence values are generated corresponding to different algorithms are used to determine the medical instrument's estimated state.

Abstract: Supervisory signals from a first wireless security sensor are received at a first supervisory rate that repeatedly confirms that the first wireless security sensor remains operatively coupled to a security system controller. A first security sensor alarm is received from the first wireless security sensor and in response, the first supervisory rate is changed to a second, higher, supervisory rate. Supervisory signals are received from the first wireless security sensor at the second supervisory rate that repeatedly confirms that the first wireless security sensor remains operatively coupled to the security system controller. When a second security sensor alarm is received from the first wireless security sensor within a predetermined period of time after the first security sensor alarm, an alarm condition detection alarm is issued from the security system controller.

Abstract: Systems, methods and devices provide efficient bandwidth allocation on a satellite, mobile telephone or other data connection by allowing nodes to share bandwidth for commonly-requested data. A transmission center, uplink or other gateway suitably recognizes when content requests from multiple different nodes are simultaneously requesting delivery of the same content. When the same content is recognized, the gateway device allocates shared bandwidth on the data transmission link for the requested content that is accessible to both the first and second nodes.

Abstract: A single piston air actuated disc brake with reduced taper wear of brake pads is disclosed. Said single piston air disc brake comprises a caliper (14); a piston (6); a carrier (5); an inboard pad (1); and an outboard pad (2). A centreline line (12) of both the inboard pad (1) and the outboard pad (2) are offset towards a leading side (15) of the carrier (5) for a predefined distance from the centreline (11) of the piston (6). The inboard leading abutment (10) and the outboard leading abutment (8) are configured as thinner than the inboard trailing abutment (13) and the outboard trailing abutment (9), respectively. The thickness of first back plate (1a) of the inboard pad (1) is configured as about 1.5 times to 2 times thicker than the thickness of the second back plate (2a) of the outboard pad (2). The disclosed single piston air disc brake is configured to reduce the taper wear of brake pads, thereby increases the life of the brake pads.

Abstract: A multi-port Ethernet fiber switch converts the TDD to OD and then provides the OD to multi-port Ethernet fiber switch ports for transmission on optical lines connected to the multi-port Ethernet fiber switch ports. The OD on the multiple optical lines is then transmitted to multiple integrated converter/receiver in-wall mounted data access stations through the multiple optical lines. Each integrated converter/receiver in-wall mounted data access station includes an integrated OD to TDD converter/receiver that is positioned in a cavity in the wall in which the integrated converter/receiver in-wall mounted data access station resides. Each integrated converter/receiver in-wall mounted data access station includes one or more data ports, such as standard RJ-45 ports.

Abstract: Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.

Abstract: Disclosed herein are small molecule aryl hydrocarbon receptor (AhR) modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Abstract: Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor for sensing an analyte level in a bodily fluid of a subject. In particular, disclosed herein are various embodiments of sensor control devices, and components thereof, designed to reduce the size and the number of internal components of the sensor control device. Further, the embodiments of the sensor control device and related sensor features disclosed herein are designed to increase comfort and convenience for the subject.

Abstract: Disclosed herein are methods of electrostatically printing a cyclodextrin composition on a substrate, the method including forming an electrostatically printable composition comprising a polymer and one or more cyclodextrins, one or more cyclodextrin inclusion complexes, or a combination thereof, and electrostatically printing the composition on a substrate. Also described are electrostatically printable compositions, methods of making the compositions, printing systems employing the compositions, substrates having the composition electrostatically printed thereon, laminates thereof, and uses of the printed substrates and laminates.

Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.

Abstract: A method for dynamically modifying a multi-layer digital asset in a digital environment includes retrieving, from a digital blockchain ledger, data associated with a primary non-fungible token (NFT) representing a primary digital asset; retrieving, from the digital blockchain ledger, data associated with a sub-asset NFT; monitoring a location of a user; determining that the user has crossed a predefined geofence boundary; in response to determining that the user has crossed the predefined geofence boundary, modifying the primary digital asset by incorporating visual elements from the sub-asset NFT; and displaying the modified primary digital asset within the digital environment.