Abstract: Disclosed herein is a method of inhibiting T Follicular Helper (TFH) cell-mediated differentiation and/or activation in a subject. This method involves administering to a subject in need of treatment for an autoimmune disorder a eukaryotic translation initiation factor 4E (eIF4E) inhibitor to inhibit TFH cell-mediated differentiation and/or activation in the subject. Also disclosed is a method of inhibiting T Follicular Helper (THF) cell differentiation or TFH cell activity.

Abstract: NAND string configurations and semiconductor memory arrays that include such NAND string configurations are provided. Methods of making semiconductor memory cells used in NAND string configurations are also described.

Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).

Abstract: A box blank useful for forming a container includes a first layer comprising paperboard, a second layer comprising a paper layer and a foil layer, and an adhesive layer adhering the first layer to the second layer, wherein the foil layer is between the paperboard and the paper layer.

Abstract: Embodiments of golf club heads with energy storage characteristics are presented herein. In some embodiments, a golf club head comprises a body comprising a strikeface, a heel region, a toe region opposite the heel region, a sole, a crown, and an internal radius transition from the strikeface to at least one of the sole or the crown. In many embodiments, the internal radius transition region is not visible from an exterior of the golf club head and comprises a first tier, a second tier and a tier transition region between the first tier and the second tier.

Abstract: An illustrative approach accelerates file indexing operations for block-level backup copies in a data storage management system. A cache storage area is maintained for locally storing and serving key data blocks, thus relying less on retrieving data on demand from the backup copy. File indexing operations are used for populating the cache storage area for speedier retrieval during subsequent live browsing of the same backup copy, and vice versa. The key data blocks cached while file indexing and/or live browsing an earlier backup copy help to pre-fetch corresponding data blocks of later backup copies, thus producing a beneficial learning cycle. The approach is especially beneficial for cloud and tape backup media, and is available for a variety of data sources and backup copies, including block-level backup copies of virtual machines (VMs) and block-level backup copies of file systems, including UNIX-based and Windows-based operating systems and corresponding file systems.

Abstract: Separator and electrolyte composites include a porous self-supporting separator film between or adjacent one or two electrolyte films. The electrolyte films may contain a glyme or mixture of glymes, LiX salt and complexing agent, such as PEO. The porous self-supporting separator film may be used dry or wetted with a liquid electrolyte composition. Solid state batteries and electrochemical cells are disclosed that include the described separator and electrolyte composites in combination with an anode and a cathode.

Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3, C1-C4 alkyl, aryl or heteroaryl; X is N or CR6, wherein R6 is H, OH, or halogen; A is absent or present, and when present is B has the structure: or a pharmaceutically acceptable salt thereof.

Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

Abstract: The present invention provides a method of treating a subject afflicted with cancer comprising administering to the subject an effective amount of a PP2A inhibitor.

Abstract: Embodiments of a next generation Node-B (gNB), User Equipment (UE) and methods for communication are generally described herein. A gNB may be configurable to operate as a master gNB (MgNB). The MgNB may transmit radio-resource control (RRC) signaling to provide information for dual connectivity to allow the UE to utilize radio resources of both a master cell group (MCG) associated with the MgNB and a secondary cell group (SCG) associated with a secondary gNB (SgNB). The MgNB may transmit, to the SgNB, an SgNB release request message that indicates a partial suspension of the dual connectivity, wherein: a first portion of a configuration for the SCG is to be maintained and a second portion of the configuration for the SCG is to be released.

Abstract: According to one aspect of the present disclosure, a gaming system is provided for tracking chips in a gaming environment. In some embodiments, an apparatus, system, etc. comprises a chip tray having one or more image sensors. The apparatus further comprises a tracking controller. The chip tray includes columns. The image sensor(s) are positioned between a least two of the columns and aligned substantially parallel to a vertical height of the columns. The tracking controller is configured, in some embodiments, to perform operations that cause the apparatus to capture, via the one or more image sensors, image data of a chip stack in at least one of the two of the columns. The tracking controller is further configured to segment the chip stack from the image data, and detect, via a machine learning model, a value of each chip in the chip stack in response analysis of chip-edge features of each gaming chip in the chip stack.

Abstract: The present invention comprises methods, compositions, devices and systems for determining the status of, or treating, a body structure or conduit. An embodiment of the invention comprises a fluid pressure control device for pressure control of fluid introduced into a body structure or conduit.

Abstract: Methods, computer-readable media, software, and apparatuses may assist in assessing proportional fault in an automobile accident involving an automobile having one or more autonomous features. An expected behavior of an autonomous feature is compared to an observed outcome of an accident and a fault proportion between a human driver and the autonomous feature may be determined, based on the comparison.

Abstract: An electrosurgical system includes an electrosurgical instrument having an electrode with a polymeric dielectric coating; and an electrosurgical generator, which includes a power converter configured to generate RF energy; a sensor coupled to the power converter and configured to sense a parameter of the RF energy; and a controller coupled to the sensor and the power converter. The controller is configured to control the power converter to output an RF waveform to achieve conductor breakthrough through the polymeric dielectric coating. The controller is further configured to determine whether the conductor breakthrough occurred based on the parameter; and execute a treatment algorithm based on a determination of the conductor breakthrough.

Abstract: An information handling system is disclosed and includes a processor, a memory, a power management unit (PMU), at least two antennas, and a wireless interface operatively coupled to the at least two antennas. The processor may execute code instructions for a distance and direction detection module therein configured to enable phase-based ranging with narrow band tone exchange, to add at least one constant tone duration to a wireless data signal frame, to monitor for nearby peripheral devices, and to measure at least two distances between each of the at least two antennas at the information handling system and a nearby peripheral device using switching between the at least two antennas.