Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).

Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.

Abstract: An apparatus for determining temperatures of substrates in microwave and/or vacuum environments. A substrate holder with a plurality of support pins includes a temperature sensor assembly with at least a portion of a surface with a phosphorous coating is configured to be inserted in at least one pin support position from an inner area of the substrate holder and in at least one pin support position from an outer area of the substrate holder. The temperature sensor assembly includes a temperature sensor pin with a spring that is microwave transparent. The temperature sensor pin is made of a material with a thermal conductivity greater than approximately 200 W/mK and a low thermal mass which is microwave transparent. An optical transmission assembly is embedded into at least a portion of the substrate holder to receive light emissions from a surface of the temperature sensor pin.

Abstract: A device for increasing a user's awareness of his or her breathing includes a clip configured to attach to a user's nose, a hinge connected to the clip, an air deflection plate pivotably connected to the hinge and one or more sensors coupled with the air deflection plate. The air deflection plate is configured to pivot relative to the clip to at least partially deflect air flow into or out of a nostril while the air deflection plate is exterior to the nostril and the clip is attached to the user's nose. The one or more sensors are configured to sense data pertaining to the user's breathing through the nostril. A method for increasing breathing awareness includes, in response to air flow across an air deflection plate pivotably coupled with a clip gripping a user's nose, receiving breathing data with one or more sensors coupled with the air deflection plate.

Abstract: A gas turbine engine, system, and method of severing at least one blade of a row of blades spaced about a rotor during an over speed condition are provided. The gas turbine engine includes a shaft rotatable about an axis of the shaft, a rotor coupled to the shaft and having a radially outer surface, and one or more rows of blades spaced axially along the outer portion. Each row of blades includes a plurality of blades spaced circumferentially around the radially outer surface. A gas turbine engine casing at least partially surrounds the one or more rows of blades. One or more rows of stationary vanes are spaced axially along the casing. Each row of stationary vanes includes a plurality of stationary vanes extending radially between the shaft and the gas turbine engine casing. The stationary vanes are coupled to the gas turbine engine casing using a fuse element.

Abstract: A gas turbine engine having a heat absorption device and an associated method are disclosed. The gas turbine engine includes a compressor having a compressor discharge nozzle, a combustor coupled to the compressor, a turbine coupled to the combustor and the compressor, a fluid flow passage fluidly coupling the compressor and the turbine and bypassing the combustor, and a heat absorption device disposed fluidly along the fluid flow passage at a first predefined location. The heat absorption device includes a casing having an inlet and an outlet, a flow path within the casing and extending between the inlet and the outlet, wherein the flow path directs an input bleed flow diverted from a fluid stream discharged from the compressor, and a phase change material hermetically sealed within the casing. The phase change material is separated from the flow path.

Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).

Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.

Abstract: A method including generating a first list of fulfillment nodes of fulfillment nodes that are enabled to deliver within a first shipping time period. The method also can include sending each fulfillment node to a separate instance of a multi-threaded worker system. The method additionally can include generating a list of zip codes that the input fulfillment node can deliver to via ground shipping within the first shipping time period. The method additionally can include transforming the lists of zip codes to generate a mapping from each zip code in the lists of zip codes to a list of fulfillment nodes of the fulfillment nodes that can deliver via ground shipping to the each zip code within the first shipping speed. The method additionally can include receiving a request including an input zip code and an input shipping time period.

Abstract: A method including determining a zip code of a user using a website that displays items. The method also can include receiving a selection by the user to display information about an item of the items. The method additionally can include retrieving first information including a predetermined geo-classification for the item. The method further can include retrieving second information including a list of fulfillment nodes that can currently deliver to the zip code of the user within a first shipping speed via ground shipping. The method additionally can include retrieving third information including a node-level inventory for the item. The method further can include determining a shipping speed to display to the user for the item based on (a) the predetermined geo-classification for the item, (b) the list of fulfillment nodes that can currently deliver to the zip code of the user within the first shipping speed, and (c) the node-level inventory for the item.

Abstract: A gas turbine engine having a heat absorption device and an associated method are disclosed. The gas turbine engine includes a compressor, a combustor, a turbine, a bleed fluid cavity, and the heat absorption device. The combustor is coupled to the compressor. The turbine is coupled to the compressor and the combustor. The bleed fluid cavity is formed at a first predefined location in the compressor. The heat absorption device is disposed in the bleed fluid cavity and includes a casing, a flow path, and a phase change material. The casing includes an inlet and an outlet. The flow path is within the casing, extends between the inlet and the outlet, and directs an input bleed fluid separated from a fluid stream discharged from the compressor. The phase change material is filled in the casing, separated from the flow path.

Abstract: A method of accessing a multiprotocol label switching (MPLS) network includes routing data traffic from a network device to the MPLS network via a primary access network that connects the network device to the MPLS network, measuring a plurality of parameters of the primary access network, predicting a future change in at least one of the parameters of the primary access network based on measurements of the plurality of parameters of the primary access network, and routing data traffic to the MPLS network through a secondary access network that connects the network device to the MPLS network based on the prediction of the future change in the at least one of the parameters of the primary access network.

Abstract: A valve for use in connection with microfluidic devices includes a safety feature such that flow is controlled even in the case of a loss of power, thus having applications in critical applications such as the precise delivery of drugs overtime. The valve may be used in connection with multiple tubes delivering drugs, and may be used with a pump, such as an electrochemical pump, to provide the force to move the fluids containing drugs for delivery. In certain applications, more than one medicine may be delivered and metered independently using a single pump with multiple reservoirs and valves.

Abstract: A laser-transmitting machining tool is disclosed. The laser-transmitting machining tool has a plurality of faces including an entrance face, a rake face, a flank face connected to the rake face, a rake side face extending between the entrance face and the rake face, and a flank side face extending between the entrance face and the flank face. The connection of the rake face to the flank face defines a cutting edge. The rake face extends away from the rake side face to define a rake angle. The entrance face is configured to receive and refract a laser beam to the rake face, the flank face, and the cutting edge for causing the laser beam to refract into and heat the workpiece at a compression region extending proximate at least the rake face and a tensile region extending proximate the flank face. A system for machining a workpiece is disclosed. A method for machining a workpiece is also disclosed.

Abstract: A method for image correction in a mobile X-ray device includes obtaining an X-ray image corresponding to a region of interest, where the X-ray image includes a projection of the region of interest by an X-ray beam on a detector plane. The method further includes receiving a tilt parameter corresponding to the detector plane. Moreover, the method includes generating a corrected X-ray image based on the X-ray image and the tilt parameter using a perspective projection technique, where the corrected X-ray image corresponds to a projection of the region of interest on a corrected detector plane.

Abstract: A collaborative speech processing computer receives packets of sampled audio streams. The sampled audio streams are forwarded to a speech-to-text conversion server via a data network. Packets are received via the data network that contain text strings converted from the sampled audio steams by the speech-to-text conversion server. Speakers are identified who are associated with the text strings contained in the data packets. The text strings and the identifiers of the associated speakers are added to a dialog data structure in a repository memory. Content of at least a portion of the dialog data structure is displayed on a display device.

Abstract: A laser-transmitting machining tool is disclosed. The laser-transmitting machining tool has a plurality of faces including an entrance face, a rake face, a flank face connected to the rake face, a rake side face extending between the entrance face and the rake face, and a flank side face extending between the entrance face and the flank face. The connection of the rake face to the flank face defines a cutting edge. The rake face extends away from the rake side face to define a rake angle. The entrance face is configured to receive and refract a laser beam to the rake face, the flank face, and the cutting edge for causing the laser beam to refract into and heat the workpiece at a compression region extending proximate at least the rake face and a tensile region extending proximate the flank face. A system for machining a workpiece is disclosed. A method for machining a workpiece is also disclosed.

Abstract: A valve for use in connection with microfluidic devices includes a safety feature such that flow is controlled even in the case of a loss of power, thus having applications in critical applications such as the precise delivery of drugs over time. The valve may be used in connection with multiple tubes delivering drugs, and may be used with a pump, such as an electrochemical pump, to provide the force to move the fluids containing drugs for delivery. In certain applications, more than one medicine may be delivered and metered independently using a single pump with multiple reservoirs and valves.

Abstract: Described in detail herein are simulation systems for a production environment and related methods of use. In one exemplary system a routing application receives a request associated with one or more physical objects. Based on the request, the routing application retrieves one or more simulation profiles from a database and forwards the request and the simulation profiles to a first computing system. The first computing system hosts a simulation environment and simultaneously executes a simulation of the request for each simulation profile in the simulation environment. The first computing system generates resultant data in response to executing each simulation that may be used to alter a production application for a production environment.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for generating and utilizing a touchpoint attribution attention neural network to identify and measure performance of touchpoints in digital content campaigns. For example, a deep learning attribution system trains a touchpoint attribution attention neural network using touchpoint sequences, which include user interactions with content via one or more digital media channels. In one or more embodiments, the deep learning attribution system utilizes the trained touchpoint attribution attention neural network to determine touchpoint attributions of touchpoints in a target touchpoint sequence. In addition, the deep learning attribution system can utilize the trained touchpoint attribution attention neural network to generate conversion predictions for target touchpoint sequences and to provide targeted digital content over specific digital media channels to client devices of individual users.