Patents by Inventor Said Saim

Said Saim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7268211
    Abstract: A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid processing techniques: wherein RA, R3, R4, D and A are as defined herein. This invention has particular application for removing ruthenium-containing catalyst and ruthenium-containing catalyst by products from reaction mixtures that result from ring-closing olefin metathesis (RCM) reactions.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: September 11, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Fabrice Gallou, Said Saim, Nathan K. Yee
  • Publication number: 20050154186
    Abstract: A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid processing techniques: wherein RA, R3, R4, D and A are as defined herein. This invention has particular application for removing ruthenium-containing catalyst and ruthenium-containing catalyst by products from reaction mixtures that result from ring-closing olefin metathesis (RCM) reactions.
    Type: Application
    Filed: December 7, 2004
    Publication date: July 14, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Fabrice Gallou, Said Saim, Nathan Yee
  • Patent number: 6884911
    Abstract: A method for repeatedly converting a solvent from a state of solvent to a state of antisolvent with relatively little loss of solvent. The method is used to allow for processing of large amounts of solute material with minimum amounts of solvent.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: April 26, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Said Saim, Stephen Horhota, David Joseph Bochniak
  • Patent number: 6858166
    Abstract: Disclosed is a method of small particle precipitation, retention and dispersion of a solid or semi-solid material onto or into a carrier material. In this method, solute particles are precipitated from a pressurized gaseous fluid solution or a liquid solution and effectively retained and dispersed within a carrier material. This technique can be advantageously used in pharmaceutical processing to produce a blend of solid or semi-solid material particles and carrier material, a granulation of the solid or semi-solid material particles with carrier material, carrier material partially or fully coated with the solid or semi-solid material particles, or mixtures thereof.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: February 22, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Said Saim, Stephen Horhota, Kenneth James Koenig, David Joseph Bochniak
  • Publication number: 20040014590
    Abstract: Methods for removing soluble material from confined spaces within substrates such as containers, capsules and porous powders comprising extraction with supercritical fluids, the pressure of which is preferably modulated between an upper level and a lower level within a relatively narrow range of fluid pressure and density. The method permits enhanced extraction efficiency, catalytic reaction rates and ability to maintain catalyst activity.
    Type: Application
    Filed: July 16, 2003
    Publication date: January 22, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Stephen Horhota, Said Saim
  • Publication number: 20030211159
    Abstract: Method for reducing the level of residual organic solvent in a carbomer comprising exposing a carbomer containing residual organic solvent to a gaseous fluid in which said residual organic solvent is substantially soluble and under conditions sufficient to extract at least some of the residual organic solvent from the carbomer; carbomers treated by this method and pharmaceutical suspensions containing the treated carbomer and a therapeutically active agent. This method is effective for the reduction of residual organic solvent in carbomer down to the ppm level, e.g., less than 30 ppm, preferably less than 10 ppm, more preferably less than 2 ppm of residual organic solvent.
    Type: Application
    Filed: April 21, 2003
    Publication date: November 13, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: David Joseph Bochniak, Cecile N. Forness, Stephen Horhota, Said Saim
  • Patent number: 6610624
    Abstract: Methods for removing soluble material from confined spaces within substrates such as containers, capsules and porous powders comprising extraction with supercritical fluids, the pressure of which is preferably modulated between an upper level and a lower level within a relatively narrow range of fluid pressure and density. The method permits enhanced extraction efficiency, catalytic reaction rates and ability to maintain catalyst activity.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: August 26, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Stephen T. Horhota, Said Saim
  • Publication number: 20030066800
    Abstract: Disclosed is a method of small particle precipitation, retention and dispersion of a solid or semi-solid material onto or into a carrier material. In this method, solute particles are precipitated from a pressurized gaseous fluid solution or a liquid solution and effectively retained and dispersed within a carrier material. This technique can be advantageously used in pharmaceutical processing to produce a blend of solid or semi-solid material particles and carrier material, a granulation of the solid or semi-solid material particles with carrier material, carrier material partially or fully coated with the solid or semi-solid material particles, or mixtures thereof.
    Type: Application
    Filed: October 10, 2002
    Publication date: April 10, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Said Saim, Stephen Horhota, Kenneth James Koenig, David Joseph Bochniak
  • Publication number: 20010055561
    Abstract: A method for repeatedly converting a solvent from a state of solvent to a state of antisolvent with relatively little loss of solvent. The method is used to allow for processing of large amounts of solute material with minimum amounts of solvent.
    Type: Application
    Filed: January 30, 2001
    Publication date: December 27, 2001
    Inventors: Said Saim, Stephen Horhota, David Joseph Bochniak
  • Publication number: 20010036898
    Abstract: Methods for removing soluble material from confined spaces within substrates such as containers, capsules and porous powders comprising extraction with supercritical fluids, the pressure of which is preferably modulated between an upper level and a lower level within a relatively narrow range of fluid pressure and density. The method permits enhanced extraction efficiency, catalytic reaction rates and ability to maintain catalyst activity.
    Type: Application
    Filed: June 12, 2001
    Publication date: November 1, 2001
    Inventors: Stephen T. Horhota, Said Saim
  • Patent number: 6294194
    Abstract: Methods for removing soluble material from confined spaces within substrates such as containers, capsules and porous powders comprising extraction with supercritical fluids, the pressure of which is preferably modulated between an upper level and a lower level within a relatively narrow range of fluid pressure and density. The method permits enhanced extraction efficiency, catalytic reaction rates and ability to maintain catalyst activity.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: September 25, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Stephen T. Horhota, Said Saim
  • Patent number: 6228394
    Abstract: Hard shelled capsules and dry, powdered pharmaceutical formulations are treated with supercritical fluids to remove impurities such as mold lubricants and moisture.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: May 8, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Stephen T. Horhota, Said Saim
  • Patent number: 5874029
    Abstract: A method and an apparatus useful for the production of microparticles and nanoparticles are disclosed in which a compressed fluid and a solution including a solvent and a solute are introduced into a nozzle to produce a mixture. The mixture is then passed out of the nozzle to produce a spray of atomized droplets. The atomized droplets are contacted with a supercritical antisolvent to cause depletion of the solvent in the droplets so that particles are produced from the solute. Preferably, these particles have an average diameter of 0.6 .mu.m or less. The invention can be used in the pharmaceutical, food, chemical, electronics, catalyst, polymer, pesticide, explosives, and coating industries, all of which have a need for small-diameter particles.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: February 23, 1999
    Assignee: The University of Kansas
    Inventors: Bala Subramaniam, Said Saim, Roger A. Rajewski, Valentino Stella
  • Patent number: 5833891
    Abstract: Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets; the enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 .mu.m. In coating processes, a turbulent fluidized flow of core particles is created using an SCF antisolvent in an enclosed zone. The core particles are contacted therein at near- or supercritical conditions by a fluid dispersion containing a dispersant together with a precipitatable substance. The antisolvent depletes the dispersant and the substance is precipitated onto the fluidized core particles.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: November 10, 1998
    Assignee: The University of Kansas
    Inventors: Bala Subramaniam, Said Saim, Roger A. Rajewski, Valentino Stella
  • Patent number: D513639
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: January 17, 2006
    Inventors: Said Saim, Stephen Horhota, Leigh Ann Rondano, Michael Hardy
  • Patent number: D515701
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: February 21, 2006
    Inventors: Stephen Horhota, Said Saim, Leigh Ann Rondano, Michael Hardy
  • Patent number: D480811
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: October 14, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Stephen Horhota, Said Saim, Leigh Ann Rondano, Michael Hardy
  • Patent number: D481131
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: October 21, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Said Saim, Stephen Horhota, Leigh Ann Rondano, Michael Hardy
  • Patent number: D492416
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: June 29, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Stephen Horhota, Said Saim, Leigh Ann Rondano, Michael Hardy
  • Patent number: D492786
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: July 6, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Said Saim, Stephen Horhota, Leigh Ann Rondano, Michael Hardy