Publication number: 20050171140
Abstract: Compounds are provided having the following structure and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, U, V, W, Y, and n are as defined above, which compounds are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer's disease and osteoporosis and may be employed as hormone replacement therapy. A method for treating the above diseases employing the above compounds is also provided.
Type:
Application
Filed:
November 15, 2004
Publication date:
August 4, 2005
Inventors:
Stephen O'Connor, Jeffrey Robl, Saleem Ahmad, Sharon Bisaha, Natesan Murugesan, Khehyong Ngu, Yan Shi, Philip Stein, Nachimuthu Soundararajan, Kenneth Natalie, Laxma Kolla, Justin Sausker, Sandra Quinlan, Junying Fan, Dejah Petsch, Zhenrong Guo
Patent number: 6664250
Abstract: Lactam derivatives of the formula
where
X is —C(═O)NR3′—, —NR3′C(═O)—, —C(═NCN)NR3′—, —NR3′C(═NCN)—, —CH2NR3′—, —CH(alkyl)NR3′—, —CH(COOalkyl)NR3′—, —CH(CH2OH)NR3′—, —C(CH2Oalkyl)—;
R1 is halo, alkyl, cycloalkyl, alkyl(cycloalkyl), aryl, (aryl)alkyl, (aryl)alkenyl, (aryl)alkynyl, O-alkyl, O-alkenyl, O-aryl, O-alky(aryl), O-alkyl(heterocyclo), COO-alkyl, C)-alkyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted amino, NHCO-alkyl, NHCO-aryl, NHCO-alkyl(aryl), NHCO-alkyl(heterocyclo), N(alkyl)CO-alkyl, N(alkyl)CO-aryl, N(alkyl)CO-heterocyclo, N(alkyl)CO-alkyl(aryl), N(alkyl)CO-alkyl(heterocyclo);
R2 is hydrogen, alkyl, halo, aryl, (aryl)alkyl, O-alkyl, amino, substituted amino;
R3 and R3′ are the same or different and are independently selected from hydrogen, alkyl or alkyl(aryl);
R4 which
Type:
Grant
Filed:
October 9, 2002
Date of Patent:
December 16, 2003
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Karnail S. Atwal, Saleem Ahmad, Francis N. Ferrara
Patent number: 6262068
Abstract: Lactam derivatives of the formula
where
X is —C(═O)NR3′—, —NR3′C(═O)—, —C(═NCN)NR3′—, —NR3′C(═NCN)—, —CH2NR3′—, —CH(alkyl)NR3′—, —CH(COOalkyl)NR3′—, —CH(CH2OH)NR3′—, —C(CH2Oalkyl)—;
R1 is halo, alkyl, cycloalkyl, alkyl(cycloalkyl), aryl, (aryl)alkyl, (aryl)alkenyl, (aryl)alkynyl, O-alkyl, O-alkenyl, O-aryl, O-alky(aryl), O-alkyl(heterocyclo), COO-alkyl, C)-alkyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted amino, NHCO-alkyl, NHCO-aryl, NHCO-alkyl(aryl), NHCO-alkyl(heterocyclo), N(alkyl)CO-alkyl, N(alkyl)CO-aryl, N(alkyl)CO-heterocyclo, N(alkyl)CO-alkyl(aryl), N(alkyl)CO-alkyl(heterocyclo);
R2 is hydrogen, alkyl, halo, aryl, (aryl)alkyl, O-alkyl, amino, substituted amino;
R3 and R3′ are the same or different and are independently selected from hydrogen, alkyl or alkyl(aryl);
R4 which
Type:
Grant
Filed:
January 14, 1999
Date of Patent:
July 17, 2001
Assignee:
Bristol-Myers Squibb Company
Inventors:
Karnail S. Atwal, Saleem Ahmad, Francis N. Ferrara
