Patents by Inventor Sampath Kumar Anandan

Sampath Kumar Anandan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20240150314
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: October 2, 2023
    Publication date: May 9, 2024
    Inventors: Sampath Kumar ANANDAN, Joshua ODINGO, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY
  • Compounds for the reducing lipotoxic damage
    Patent number: 11976040
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: May 7, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • Dichlorophenol HSD17B13 inhibitors and uses thereof
    Patent number: 11827619
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Grant
    Filed: May 10, 2023
    Date of Patent: November 28, 2023
    Assignee: INIPHARM, INC.
    Inventors: Sampath Kumar Anandan, Joshua Odingo, Heather Kay Webb Hsu, Vincent Florio, Subramanyam Janardhan Tantry, Athisayamani Jeyaraj Duraiswamy
  • QUINAZOLINONE HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20230286923
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: July 23, 2021
    Publication date: September 14, 2023
    Inventors: Joshua ODINGO, Sampath Kumar ANANDAN, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY, Bharathi Mohan KUPPUSAMY
  • THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20230278978
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: July 23, 2021
    Publication date: September 7, 2023
    Inventors: Joshua ODINGO, Sampath Kumar ANANDAN, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY
  • DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20230278981
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: May 10, 2023
    Publication date: September 7, 2023
    Inventors: Sampath Kumar ANANDAN, Joshua ODINGO, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY
  • COMPOUNDS FOR THE REDUCING LIPOTOXIC DAMAGE
    Publication number: 20230250057
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 3, 2023
    Publication date: August 10, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • Compounds for the reducing lipotoxic damage
    Patent number: 11623915
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: April 11, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • COMPOUNDS FOR THE REDUCING LIPOTOXIC DAMAGE
    Publication number: 20220324797
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 20, 2022
    Publication date: October 13, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • Compounds for the reducing lipotoxic damage
    Patent number: 11339126
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: May 24, 2022
    Assignees: Mayo Foundation for Medical Education and Research, Nanosyn, Inc.
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • COMPOUNDS FOR THE REDUCING LIPOTOXIC DAMAGE
    Publication number: 20210139421
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 12, 2018
    Publication date: May 13, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • Opioid agonist peptides and uses thereof
    Patent number: 10729676
    Abstract: The invention is directed to opioid agonist peptides and their use.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: August 4, 2020
    Assignee: Protagonist Theraputics, Inc.
    Inventors: Sampath Kumar Anandan, Jie Zhang, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick, Larry C. Mattheakis, David Liu, Mukund M. Mehrotra
  • Methods for synthesizing ?4?7 peptide antagonists
    Patent number: 10407468
    Abstract: The present invention provides methods of making ?4?7 peptide monomer and dimer antagonists. Methods of the present invention include solid phase and solution phase methods, as well as synthesis via condensation of smaller peptide fragments. Methods of the present invention further include methods directed to the synthesis of peptides comprising one or more penicillamine residues.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: September 10, 2019
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Suresh Kumar Manthati, Mukund M. Mehrotra, Sampath-Kumar Anandan, Dinesh V. Patel
  • OPIOID AGONIST PEPTIDES AND USES THEREOF
    Publication number: 20190231746
    Abstract: The invention is directed to opioid agonist peptides and their use.
    Type: Application
    Filed: March 6, 2019
    Publication date: August 1, 2019
    Inventors: Sampath-Kumar Anandan, Jie Zhang, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick, Larry C. Mattheakis, David Liu
  • Opioid agonist peptides and uses thereof
    Patent number: 10278957
    Abstract: The invention is directed to opioid agonist peptides and their use.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: May 7, 2019
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Sampath Kumar Anandan, Jie Zhang, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick, Larry C. Mattheakis, David Liu
  • OPIOID AGONIST PEPTIDES AND USES THEREOF
    Publication number: 20190076400
    Abstract: The invention is directed to opioid agonist peptides and their use.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Inventors: Sampath Kumar Anandan, Jie Zhang, Ashok Bhandari, Gregory Thomas Bourne, Brian Troy Frederick, Larry C. Mattheakis, David Liu
  • METHODS FOR SYNTHESIZING alpha4ß7 PEPTIDE ANTAGONISTS
    Publication number: 20170327541
    Abstract: The present invention provides methods of making ?4?7 peptide monmer and dimer antagonists. Methods of the present invention include solid phase and solution phase methods, as well as synthesis via condensation of smaller peptide fragments. Methods of the present invention further include methods directed to the synthesis of peptides comprising one or more penicillamine residues.
    Type: Application
    Filed: March 23, 2017
    Publication date: November 16, 2017
    Inventors: Ashok Bhandari, Suresh Kumar Manthati, Mukund M. Mehrotra, Sampath-Kumar Anandan, Dinesh V. Patel
  • 2?-ethynyl nucleoside derivatives for treatment of viral infections
    Patent number: 9814739
    Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2?-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: November 14, 2017
    Assignee: Novartis AG
    Inventors: Sampath-Kumar Anandan, Virender Singh Aulakh, Martijn Fenaux, Xiaodong Lin, Liang Mao, Oliver Saunders, Zachary Kevin Sweeney, Fumiaki Yokokawa, Weidong Zhong
  • 2'-Ethynyl Nucleoside Derivatives for Treatment of Viral Infections
    Publication number: 20170112868
    Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2?-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
    Type: Application
    Filed: December 14, 2016
    Publication date: April 27, 2017
    Inventors: Sampath-Kumar Anandan, Virender Singh Aulakh, Martijn Fenaux, Xiaodong Lin, Liang Mao, Oliver Saunders, Zachary Kevin Sweeney, Fumiaki Yokokawa, Weidong Zhong
  • 2?-Ethynyl nucleoside derivatives for treatment of viral infections
    Patent number: 9556216
    Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2?-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: January 31, 2017
    Assignee: Novartis AG
    Inventors: Sampath-Kumar Anandan, Virender Singh Aulakh, Martijn Fenaux, Xiaodong Lin, Liang Mao, Oliver Saunders, Zachary Kevin Sweeney, Fumiaki Yokokawa, Weidong Zhong