Abstract: Deuterium-containing analogs/derivatives of N,N,N-trimethyl phosphoryloxytryptamine are disclosed. The deuterated compounds can be incorporated into pharmaceutical compositions and used to treat diseases such as psychological diseases and disorders.

Abstract: Disclosed herein are isotopically enriched compounds of the formula including enantiomers and mixtures thereof, as well as methods for their use and the use of MDE in treating neurologic and brain disorders.

Abstract: Systems and methods of epidemiological modeling using machine learning are provided, and can include receiving values for an occurrence of the infectious disease during a first time period, generating, from a model trained by a machine learning system, predictions for the occurrence of the infectious disease over a second time period, performing, by a simulator using the predictions, one or more simulations of the occurrence of the infectious disease in one or more geographic regions during one or more time periods subsequent to the second time period, and providing, to a user interface, a first simulation of the one or more simulations performed by the simulator for a first geographic region of the one or more geographic regions during a time period of the one or more time periods.

Abstract: An exemplary system, method and computer-accessible medium for harmonizing neuromelanin (NM) data using combat directly on a NM database or using combat generated coefficients to harmonize future data can include, for example, receiving imaging information of a brain of the patient(s), from one MRI scanner, receiving imaging information of a brain of the patient(s), from a second MRI scanner and using combat to harmonize the data between scanners against a reference dataset. The Neuromelanin (NM) concentration of the patient(s) can then be determined based on the harmonized data. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s).

Abstract: A neuromelanin sensitive magnetic resonance imaging (“MRI”) technique, method and computer-accessible medium for measuring the extent of, providing a diagnosis of, monitoring the treatment of, assessing novel treatments for, or determining a prognosis related to Parkinson's disease.

Abstract: The subject matter of this disclosure relates to systems and methods for monitoring and managing machine learning models and related data. Histogram structures can be used to aggregate streams of numerical data for storage and metric calculations. Drift in such data can be identified and monitored over time. When significant drift is detected and/or when model accuracy has deteriorated, models can be automatically refreshed with updated training data and/or replaced with one or more other models. A model controller is used to automate model monitoring and management activities across multiple prediction environments where models are deployed and prediction jobs are executed.

Abstract: An embodiment of the present disclosure provides a footwear including a sole and at least one upper. The sole includes: a sole body; and at least one first mating connector located on the sole body. The at least one upper includes: an upper body; and at least one first mating connector located on the upper body. Each of the at least one first mating connector of the upper is configured to be detachably attached to one of the at least one first mating connector of the at least one sole.

Abstract: An optoelectronic device configured to operate at an electromagnetic radiation frequency having metal wire electrodes that are optically transparent as a result of the wires having an effective plasma frequency that is equal to or lower than the electromagnetic frequency at which the device operates. The effective plasma frequency of the wire is lowered by configuring the path of the wire between the terminal ends to be meandering, serpentine, U-shaped and in other non-linear configurations.

Abstract: Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces The present invention provides a method of covalently attaching a polymeric monolith to the internal surface of polyether ether ketone (PEEK) tubing and column housings, comprising the steps of: (a) reducing the ketone group of the PEEK to a hydroxyl group to obtain a modified PEEK, (b) optionally reacting the hydroxyl group obtained in step (a) with a compound having an active vinyl group to form a modified PEEK selected from the group of acrylate modified PEEK, methacrylate modified PEEK, styrene modified PEEK and epoxy modified PEEK, and (c) reacting the modified PEEK obtained in step (a) or (b) with a polymer or polymerization mixture for forming the polymeric monolith. Hereby, the mechanical stability and solvent durability of larger diameter monolithic columns as well as their overall performance are improved.

Abstract: The use of CRL 5803 cells as a robust cell substrate for transgene expression of polypeptides is contemplated. Furthermore, use of CRL 5803 cells in cell-based delivery and methods of making and using the same in encapsulated devices are contemplated.

Abstract: A system and method are provided for the efficient entry and display of ground taxi routes on an electronic airport map display. The system may include a touchscreen entry device, a display device, a computer, a map database, a vehicle position sensor and a transmitter/receiver. The system may be configured to check the ground taxi entries to ensure that each successive segment is contiguous with the last or next segment, and any gaps or discontinuities in the displayed taxi instructions may be annunciated. An intelligent display of next possible segments may be incorporated into the system.

Abstract: The Retail Exposure Dispensing Machine is unique in that it can conveniently distribute most small products sold in retail establishments today using little shelf space while holding a lot of product. It continuously displays the product allowing the package advertising to do its' job. Distribution is enabled by pulling a handle connected to a pull slide which will dispense only one unit. Each succeeding pull will dispense one unit until the whole dispenser is empty. Distribution tabs on the mechanical slide allow the dispensing of one unit at a time row after row of product. If a partial pull is enacted and it does not grab another product to give out it will correct itself within one additional full pull.

Abstract: The present invention a provides methods for production of heterologous polypeptides using a variety recombinantly engineered secretory cell lines. The common feature of these cell lines is the absence of expression of at least one endogenous polypeptide. The host cell machinery normally used to produce the endogenous polypeptide is then usurped for the purpose of making the heterologous polypeptide. Also described are methods engineering cells for high level expression, methods of large scale protein production, and methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines.

Abstract: The present invention a provides methods for production of heterologous polypeptides, for example amylin, using recombinantly engineered cell lines. Also described are methods engineering cells for high level expression, methods of large scale heterologous protein production, methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines, and methods for isolating novel amylin receptors.

Abstract: The present invention a provides methods for production of heterologous polypeptides using a variety recombinantly engineered secretory cell lines. The common feature of these cell lines is the absence of expression of at least one endogenous polypeptide. The host cell machinery normally used to produce the endogenous polypeptide is then usurped for the purpose of making the heterologous polypeptide. Also described are methods engineering cells for high level expression, methods of large scale protein production, and methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines.

Abstract: There is provided an idler roll for use in belt conveyor systems comprising a shaft and at least two modular sections disposed adjacent to one another surrounding the shaft, the at least two modular sections varying in thickness as measured along an axis of the shaft. There is also provided an idler roll for use in belt conveyor systems comprising a shaft and a molded polymer coating disposed around the shaft, wherein the coating is at least partially tapered in cross section at each end of the idler roll. There is further provided a belt conveyor system for handling bulk material employing idler rolls.

Abstract: In combination with a plastic fuze radome, a structure for protecting the ternal electronic components housed within said radomes during flight, said structure being a strap-on metal cap designed to slip on or over the ogive of the radome of a fuze. This metal cap is a metal cone having two open windows. The antenna of the fuze electronics is permitted to radiate through the windows while being protected from rain damage by the large umbrella at the top over the plastic nose cone, and from heat flux into electronic components by the large metal band at the bottom. Mechanical ablation of the tip is prevented by the cone of metal acting as a heat sink and as a shield against the wind-stream stagnation pressure. Triboelectric charging is prevented by two conductive straps down the side of the structure, and by a grounding electrical connection.