Abstract: A system may include an elongate flexible device, a flexible instrument, and a processor. The elongate flexible device may include a first shape sensor configured to generate first shape data corresponding to a shape of the elongate flexible device. The flexible instrument may include a second shape sensor configured to generate second shape data corresponding to a shape of the flexible instrument. The processor may be configured to register the flexible instrument to the elongate flexible device based on the first shape data and the second shape data. The first shape data and the second shape data may be generated while the flexible instrument is mated with the elongate flexible device.

Abstract: The present disclosure relates to injectable compositions sterile injectable fluid compositions comprising a polysaccharide having a color in the visible spectrum, methods of forming the same, kits containing the same, and methods for performing agent-assisted procedures in a patient using the same.

Abstract: Compositions useful for tissue resection procedures and related methods of preparing the compositions are discussed. The composition may comprise gellan gum, at least one salt, and water. In some aspects, the composition may be prepared by combining the gellan gum, the salt(s), and the water to form a mixture, heating the mixture, introducing the mixture into a reservoir, and allowing the mixture to cool while inside the reservoir to form a gel. The gel may have a continuous, three-dimensional structure, and may be solid or quasi-solid. The composition may be biocompatible and injectable from the reservoir through a needle coupled to the reservoir to the target site of a patient.

Abstract: The present disclosure relates to injectable compositions sterile injectable fluid compositions comprising a polysaccharide having a color in the visible spectrum, methods of forming the same, kits containing the same, and methods for performing agent-assisted procedures in a patient using the same.

Abstract: A system may include an elongate flexible device, a flexible instrument, and a processor. The elongate flexible device may include a first shape sensor configured to generate first shape data corresponding to a shape of the elongate flexible device. The flexible instrument may include a second shape sensor configured to generate second shape data corresponding to a shape of the flexible instrument. The processor may be configured to register the flexible instrument to the elongate flexible device based on the first shape data and the second shape data. The first shape data and the second shape data may be generated while the flexible instrument is mated with the elongate flexible device.

Abstract: A handle for a medical device includes a distal portion extending longitudinally and including a distal channel extending therethrough, the distal end of the distal portion including a connector configured to connect to a proximal end of an endoscope, a central portion slidably connected to the distal portion, the central portion extending longitudinally. The handle also includes a central channel extending therethrough, the distal end of the central portion connected to a sheath, the central portion including an introducer port extending laterally therefrom so that an auxiliary tool inserted through the introducer port is directed through a lumen of the sheath. Further, the handle includes a proximal portion slidably connected to the central portion, the proximal portion extending longitudinally and including a proximal channel extending therethrough, the distal end of the proximal portion connected to a needle so that the needle is passed through the lumen.

Abstract: The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

Abstract: A system includes a flexible elongate device including an optical imaging device and a working channel, an acoustic imaging device carried by the flexible elongate device and configured to generate a plurality of acoustic images of a region of interest, and an interventional tool extendable through the working channel of the flexible elongate device. The system also includes a control system configured to receive the plurality of acoustic images of the region of interest from the acoustic imaging device and provide guidance for inserting the interventional tool along a path through an anatomic orifice and an anatomic passageway of the region of interest, wherein the guidance is generated based on the plurality of acoustic images.

Abstract: The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

Abstract: A system includes a flexible elongate device, a tool, and a controller. The flexible elongate device includes a working channel extending to an opening in a distal portion of the flexible elongate device and a plurality of imaging elements. The tool is extendable through the working channel and the opening. The controller has one or more processors configured to determine a position associated with a portion of the tool, and control at least a portion of the plurality of imaging elements to generate an image that includes an imaging plane that includes the position associated with the portion of the tool.

Abstract: A handle for a medical device includes a distal portion extending longitudinally and including a distal channel extending therethrough, the distal end of the distal portion including a connector configured to connect to a proximal end of an endoscope, a central portion slidably connected to the distal portion, the central portion extending longitudinally. The handle also includes a central channel extending therethrough, the distal end of the central portion connected to a sheath, the central portion including an introducer port extending laterally therefrom so that an auxiliary tool inserted through the introducer port is directed through a lumen of the sheath. Further, the handle includes a proximal portion slidably connected to the central portion, the proximal portion extending longitudinally and including a proximal channel extending therethrough, the distal end of the proximal portion connected to a needle so that the needle is passed through the lumen.

Abstract: According to one aspect, an instrument may include a sheath having a distal end. The instrument also may include a fluid cannula at the distal end of the sheath. The instrument also may include a cutting electrode at the distal end of the sheath. At least one of: (i) an exterior surface of the fluid cannula, and (ii) a cutting electrode surface that faces the exterior surface, is longitudinally slidable along the other of the exterior surface and the cutting electrode surface during movement of at least one of the cutting electrode and the fluid cannula relative to the other of the cutting electrode and the fluid cannula.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: According to one aspect, a medical system may include an instrument including an end effector for acting as a monopolar electrode. The end effector may be configured to be positioned in a body of a subject and emit radiofrequency energy towards a target area in the body. The medical system may further include a return electrode. The return electrode may be deliverable within the body proximate the target area and separately from the instrument and the monopolar electrode. The return electrode may be configured to contact tissue in the body proximate the target area and receive radiofrequency energy emitted from the end effector.

Abstract: In one aspect of the present disclosure, a tissue retraction system may include a first anchor, a second anchor, and an elongate coupling member extending between the first anchor and the second anchor. The system also may include a holder for receiving the first anchor, the second anchor, and the elongate coupling element. The holder may include a proximal portion and a distal portion. The distal portion may have a smaller width than the proximal portion such that the distal portion exerts a force on a proximal end of the first anchor during deployment of the first anchor from the holder. The force may move the first anchor into an open configuration for receiving tissue.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices which lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstruction of dissection tools. In particular, the present disclosure relates to a tissue retraction device which moves from a constrained to relaxed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices which lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstruction of dissection tools. In particular, the present disclosure relates to a tissue retraction device which moves from a constrained to relaxed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: A system may include an elongate flexible device, a flexible instrument, and a processor. The elongate flexible device may include a first shape sensor configured to generate first shape data corresponding to a shape of the elongate flexible device. The flexible instrument may include a second shape sensor configured to generate second shape data corresponding to a shape of the flexible instrument. The processor may be configured to register the flexible instrument to the elongate flexible device based on the first shape data and the second shape data. The first shape data and the second shape data may be generated while the flexible instrument is mated with the elongate flexible device.

Abstract: A system may comprise an elongate flexible instrument including an imaging device disposed at a distal end portion of the elongate flexible instrument. The imaging device may include a multi-directional imaging array. The elongate flexible instrument may also include a localization sensor extending within the elongate flexible instrument. The system may also comprise a controller comprising one or more processors configured to register the localization sensor to a patient anatomy and receive orientation data for the distal end portion of the elongate flexible instrument from the localization sensor. Based on the orientation data, an imaging plane of the imaging device may be selected. An image in the selected imaging plane may be displayed. The image may be generated by imaging data from the multi-directional imaging array of the imaging device.

Abstract: A system may comprise a sensing instrument including an elongate flexible member with a channel extending therein. The elongate flexible member may include a proximal portion, a distal portion, and a flexure portion between the distal and proximal portions. The sensing instrument may also include a flexure at the flexure portion of the elongate flexible member, a sensing element coupled at the distal portion of the elongate flexible member, and a flexure control apparatus extending within the elongate flexible member and configured to bend the flexure to change an orientation of the sensing element relative to the proximal portion of the elongate flexible member. The sensing instrument may also include an exit port in the proximal portion of the elongate flexible member.