Abstract: A medical/surgical device for performing tissue resection can include an endoscope with proximal and distal ends, defining working channels, and a snare assembly located in one of the working channels. The working channel may include a bend near the distal end and towards the outward radial wall of the endoscope. The snare assembly may include a snare loop and an actuation element imparted with the pre-formed angular bends and an actuation control handle. The bends of the actuation element and the working channel may be the same. The rotational manipulation of the actuation element may synchronize the pre-formed bend of the actuation element with the bend of the working channel to concentrically (or otherwise) align the deployed snare loop with the endoscope or endoscope attachments.

Abstract: A medical device may include a helical coil having a plurality of turns. The plurality of turns may define a lumen. The device may also include a composition. The composition may include gellan gum, at least one salt, water, and a treatment agent. The treatment agent may be disposed in the lumen.

Abstract: A tissue closure device includes a needle and a suture extending therefrom, a proximal head including a proximal slot and a proximal locking mechanism for releasably engaging a first end of the needle in the proximal slot in a first configuration, and a distal head movably coupled to the proximal head so that the proximal and distal heads are movable relative to one another between an open configuration, in which a target tissue is received therebetween, and a closed configuration, in which the target tissue gripped therebetween. The distal head includes a distal slot and a distal locking mechanism for releasably engaging a second end of the needle in the distal slot in a second configuration, the needle movable between the first and second configurations by rotating the needle, the needle alternatingly passed between the proximal and distal heads to thread the suture through the target tissue.

Abstract: A device for treating a tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the capsule releasably coupled to a proximal portion of the device and clip arms, proximal ends of which are slidably received within the channel of the capsule so that the clip arms are movable between an open configuration, and a closed configuration. A core member is coupled to the clip alms, the core member including a proximal portion and a distal portion releasably connected to one another so that, when the core member is subjected to a predetermined load, the proximal and distal portions are separated from one another. An electrically conductive control member is connected to the core member, a proximal end of the connected member connected to a power source for delivering an electrical current to the clip arms.

Abstract: Compositions, e.g., gels, useful for tissue resection procedures, medical devices comprising the compositions, and related methods of preparing the compositions are discussed. The composition may comprise gellan gum, two or more salts, and water. In some aspects, the composition may be prepared by combining gellan gum and water to form a pre-mixture, heating the pre-mixture, adding two or more salts to the heated pre-mixture to form a mixture, introducing the mixture into a reservoir, and allowing the mixture to form a gel inside the reservoir. The gel may have a continuous, three-dimensional structure, and have desired gel strength and viscosity. The composition may be biocompatible and injectable from the reservoir through a needle to the target site of a patient.

Abstract: A tissue cutting device includes a flexible elongate body including a channel extending therethrough, a distal member connected to a distal end of the elongate body. The distal member includes a lumen extending therethrough in communication with the channel and a recess extending through an exterior surface of the distal member along a portion of a length thereof. The recess extends includes a receiving structure at a distal end thereof. A cutting element is slidably received within the channel and the lumen so that the cutting element is movable between an open tissue-receiving configuration and a closed tissue-gripping configuration, in which a distal portion of the cutting element extends across the recess such that the distal end of the cutting element is received within the receiving structure, a portion of a length of the distal portion extending radially beyond an exterior surface of the distal member.

Abstract: A medical/surgical device for performing tissue resection can include an endoscope with proximal and distal ends, defining working channels, and a snare assembly located in one of the working channels. The working channel may include a bend near the distal end and towards the outward radial wall of the endoscope. The snare assembly may include a snare loop and an actuation element imparted with the pre-formed angular bends and an actuation control handle. The bends of the actuation element and the working channel may be the same. The rotational manipulation of the actuation element may synchronize the pre-formed bend of the actuation element with the bend of the working channel to concentrically (or otherwise) align the deployed snare loop with the endoscope or endoscope attachments.

Abstract: A medical device may include a shaft, and a first tool extending from a distal end of the shaft. The medical device also may include a control assembly coupled to the shaft. The control assembly may include a console, a first grip extending proximally from the console, and a second grip extending proximally from the console. The control assembly also may include a first deflection actuator configured to deflect the first tool about a longitudinal axis of the first tool, a first rotation actuator configured to rotate the first tool about the longitudinal axis of the first tool, and a first longitudinal actuator configured to move the first tool along the longitudinal axis of the first tool.

Abstract: The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

Abstract: A tissue closure device includes a needle and a suture extending therefrom, a proximal head including a proximal slot and a proximal locking mechanism for releasably engaging a first end of the needle in the proximal slot in a first configuration, and a distal head movably coupled to the proximal head so that the proximal and distal heads are movable relative to one another between an open configuration, in which a target tissue is received therebetween, and a closed configuration, in which the target tissue gripped therebetween. The distal head includes a distal slot and a distal locking mechanism for releasably engaging a second end of the needle in the distal slot in a second configuration, the needle movable between the first and second configurations by rotating the needle, the needle alternatingly passed between the proximal and distal heads to thread the suture through the target tissue.

Abstract: A device for treating a tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the capsule releasably coupled to a proximal portion of the device and clip arms, proximal ends of which are slidably received within the channel of the capsule so that the clip arms are movable between an open configuration, and a closed configuration. A core member is coupled to the clip arms, the core member including a proximal portion and a distal portion releasably connected to one another so that, when the core member is subjected to a predetermined load, the proximal and distal portions are separated from one another. An electrically conductive control member is connected to the core member, a proximal end of the connected member connected to a power source for delivering an electrical current to the clip arms.

Abstract: A device for treating tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a lumen extending therein and a clip slidably received within the lumen of the capsule. The clip includes a middle prong, a first outer prong and a second outer prong. The first prong is coupled to the middle prong so that the first prong is movable relative to the middle prong between a first open configuration and a first closed configuration. The second outer prong coupled to the middle prong so that the second prong is movable relative to the middle prong between a second open configuration and a second closed configuration. The first and second outer prongs are independently movable relative to the middle prong to be moved between the first and second open configurations to the first and second open configurations and the first and second closed configurations.

Abstract: A medical device may include a shaft, and a first tool extending from a distal end of the shaft. The medical device also may include a control assembly coupled to the shaft. The control assembly may include a console, a first grip extending proximally from the console, and a second grip extending proximally from the console. The control assembly also may include a first deflection actuator configured to deflect the first tool about a longitudinal axis of the first tool, a first rotation actuator configured to rotate the first tool about the longitudinal axis of the first tool, and a first longitudinal actuator configured to move the first tool along the longitudinal axis of the first tool.

Abstract: The present disclosure provides systems and methods for cutting mucosal tissue. In particular, the present disclosure provides an endoscopic hood with an integrated wire for single-step tissue cutting. The endoscopic hood is particularly useful for performing repeated cutting, for example EMR resections, without the need for assistance by a nurse or medical technician.

Abstract: A device for treating tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a lumen extending therein and a clip slidably received within the lumen of the capsule. The clip includes a middle prong, a first outer prong and a second outer prong. The first prong is coupled to the middle prong so that the first prong is movable relative to the middle prong between a first open configuration and a first closed configuration. The second outer prong coupled to the middle prong so that the second prong is movable relative to the middle prong between a second open configuration and a second closed configuration. The first and second outer prongs are independently movable relative to the middle prong to be moved between the first and second open configurations to the first and second open configurations and the first and second closed configurations.

Abstract: This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device may include a medical device for delivery of a surgical closure member. The medical device includes an elongate tubular member having a proximal end, a distal end and a lumen extending therein. The elongate tubular member is adapted to be delivered through the working channel of an endoscope and the lumen is adapted to receive a surgical closure member. The medical device also includes a tissue support extending from the distal end of the elongate tubular member. The tissue support includes a support surface and the support surface is adapted to support tissue as a surgical closure member engages the tissue thereon.

Abstract: In accordance with an aspect of the present disclosure, the medical device includes a snare member having a proximal portion and a distal portion. The medical device also includes an operating member extending proximally of the snare member. The operating is enabled to extend and retract the snare member from a sheath. The snare member includes a transition portion extending between the proximal portion and the distal portion. The transition portion connects the proximal portion to the distal portion. The distal portion has a different cross-sectional area than the proximal section of the snare member.

Abstract: Devices for physically separating biological samples and methods for separating biological samples are disclosed. An example device may include a vessel for holding a biological sample. The biological sample may include a plurality of cells and a fluid. A filter membrane may be disposed within the vessel and positioned adjacent to an end region of the vessel. An auger member may be disposed within the vessel. The auger member may be designed to drive cells within the biological sample into contact with the filter membrane.

Abstract: A device for passing a needle and suture longitudinally through a target tissue includes a proximal jaw including a proximal recess and a proximal retention mechanism for releasably engaging a first end of a needle received within the proximal recess and a distal jaw movably coupled to the proximal jaw such that the proximal and distal jaws are longitudinally movable relative to one another. The distal jaw includes a distal recess and a distal retention mechanism for releasably engaging a second end of the needle received within the distal recess. The proximal and distal jaws are movable between a first state, in which the proximal retention mechanism is in a locked configuration and the distal retention mechanism is in an unlocked configuration, and a second state, in which the proximal retention mechanism is in an unlocked configuration and the distal retention mechanism is in a locked configuration.

Abstract: The present disclosure relates to the field of medical devices generally and specifically, to endoscopic systems and methods for resection of malignant and pre-malignant lesions within the gastrointestinal (GI) tract. In particular, the present disclosure relates to systems and methods for delivering injectable compositions between tissue layers (e.g., between the muscularis and submucosa layers) to elevate and stabilize the lesion for fast and efficient resection.