Abstract: A device for treating tissue includes a helical needle extending about a longitudinal axis thereof from a distal tip to a proximal end and a control member extending longitudinally between a distal end releasably coupled to the proximal end of the helical needle and a proximal end which, when the helical needle is inserted into a body, remains outside the body, the control member configured such that rotation of the control member about the longitudinal axis rotates the helical needle to screw the helical needle distally into a target tissue.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: A device for treating a tissue opening includes a capsule extending longitudinally from a proximal end to a distal end and including a lumen extending therethrough; a pair of arms movably housed within the lumen of the capsule such that the pair of arms are movable between an open configuration and a closed configuration, the pair of arms being biased toward the open configuration such that when the pair of arms are moved distally with respect to the capsule, distal ends of the pair of arms are separated from one another to receive target tissue therebetween; a needle releasably connected to a first one of the pair of arms, the needle extending laterally inward toward a second one of the pair of arms and including a connecting structure extending along a portion thereof, the second one of the pair of arms including an opening located so that, when the pair of arms are moved to the closed configuration, the connecting structure of the needle engages the opening; and a suture extending from a portion of the nee

Abstract: Embodiments of the disclosure may include a medical device comprising a flexible elongate member including a longitudinal axis and a tool connected to the elongate member at a pivot axis, wherein the tool may be configured to conduct electricity and deliver a fluid, and wherein the tool may be configured to pivot towards either side of the longitudinal axis relative to the elongate member at the pivot axis.

Abstract: A device configured to facilitate resection of tissue. The device may include a proximal end configured to be secured to a distal portion of an introduction sheath and a distal end defining an opening that may communicate with a channel extending between the proximal and distal ends. The opening may be defined by at least one straight edge.

Abstract: A system for clipping tissue includes a clip having first and second jaws. Each of the first and second jaws defines an opening through which a control wire passes. A collapsible member is coupled between the first and second jaws. The member is biased to urge the first and second jaws away from one another along an axis of the control wire to a first expanded configuration. The first and second jaws are movable against the bias of the member via the control wire to a second contracted configuration in which the first and second jaws are moved along the axis of the control wire toward one another to lockingly engage tissue received therebetween. The movement of control wire causes a corresponding movement of the first jaw relative to the second jaw to move the first and second jaws from the first expanded configuration to the second contracted configuration.

Abstract: In accordance with an aspect of the present disclosure, the medical device includes a snare member having a proximal portion and a distal portion. The medical device also includes an operating member extending proximally of the snare member. The operating is enabled to extend and retract the snare member from a sheath. The snare member includes a transition portion extending between the proximal portion and the distal portion. The transition portion connects the proximal portion to the distal portion. The distal portion has a different cross-sectional area than the proximal section of the snare member.

Abstract: Embodiments of the present disclosure include medical devices and related methods of use, and manufacture thereof. The medical device may include a snare including an elongate actuation member and a distal snare member. The medical device may further include a snare support including first and second arms and a base member disposed proximate to the elongate actuation member. The first arm may extend from the base member to a first lateral portion of the distal snare member and the second arm may extend from the base member to a second lateral portion of the distal snare member opposite the first lateral portion. Each arm may be moveably coupled to the distal snare member.

Abstract: In one aspect, the invention provides injectable compositions that comprise a suitable hydrophilic polymer (e.g., a suitable polysaccharide) and water, as well as other optional components. In various embodiments, the composition may be provided in a suitable container, for example, in a pre-loaded syringe. In another aspect, methods of performing medical procedures in a tract of a body are provided. In yet another aspect, the invention provides systems for performing medical procedures in a tract of a body.

Abstract: A medical device for manipulating a tissue is disclosed. The device includes an elongate shaft having a proximal end, a distal end, and a first lumen between the proximal end and the distal end, which has an opening in communication with the first lumen. The elongate shaft further includes a second lumen or aperture disposed in an external surface of the elongate shaft. The device further includes: a support truss, a snare loop, and an actuation member having a distal end. The actuation member is movably disposed within the first lumen. The support truss is configured to be received within the first lumen, second lumen, or aperture such that a proximal end of the support truss is operably connected to the elongate shaft adjacent a proximal portion of the first lumen, second lumen, or aperture. The snare loop has a first portion connected to a distal end of the support truss and a second portion connected to the distal end of the actuation member.

Abstract: A tissue clipping device includes (a) a first body extending from a proximal end to a distal end and including a first channel extending therethrough and (b) a plurality of first arm elements, each of the plurality of first arm elements extending radially into the first channel from a first end coupled to the first body to a second end proximal of its first end so that tissue drawn into a distal end of the first channel proximally beyond the second end of the plurality of first arm elements is compressed between each of the plurality of first arm elements and retained in the first channel.

Abstract: A medical/surgical device for performing tissue resection can include an endoscope with proximal and distal ends, defining working channels, and a snare assembly located in one of the working channels. The working channel may include a bend near the distal end and towards the outward radial wall of the endoscope. The snare assembly may include a snare loop and an actuation element imparted with the pre-formed angular bends and an actuation control handle. The bends of the actuation element and the working channel may be the same. The rotational manipulation of the actuation element may synchronize the pre-formed bend of the actuation element with the bend of the working channel to concentrically (or otherwise) align the deployed snare loop with the endoscope or endoscope attachments.

Abstract: A medical device for resecting tissue. The medical device includes a catheter shaft having a proximal portion and two or more distal branch portions. The distal branch portions are moveable between a closed position, and an open position. One or more lumens extend between the proximal portion and through each distal branch portion. An actuation element extends through the lumen of each distal branch portion. A snare loop is connected to each actuation element.

Abstract: A medical device may include tubular member having a proximal end, a distal end, and a lumen extending therebetween. The tubular member may include an opening at a distal portion of the tubular member, wherein the opening is in communication with the lumen, wherein a distal end of the opening is disposed proximate of the distal end of the tubular member, and wherein the distal portion of the tubular member is configured to bend in at least one plane. The medical device may further include an actuation member extending at least partially within the tubular member, wherein a distal portion of the actuation member is configured to exit the tubular member at a location proximate the opening, wherein a distal end of the actuation member is coupled to the distal end of the tubular member, and wherein pulling the actuation member proximally is configured to cause the distal portion of tubular member to form a loop with itself.

Abstract: Medical devices having one or more micropatterned surfaces (e.g., micropatterned coatings).

Abstract: A medical device may include a housing. The housing may include an outer wall, an inner wall spaced from the outer wall, and a cavity defined by the outer wall and the inner wall. The distal end of the outer wall may be disposed proximally from the distal end of the inner wall. The housing may further define a passageway therethrough. The cavity may be in fluid communication with a port configured to adjust pressure within the cavity.

Abstract: A medical device and a method for manipulating a tissue are disclosed. The medical device includes two or more bars, a snare loop and a constricting element. Each bar includes a proximal end, and one or more distal ends, such that the bars are in close proximity at the proximal end. The snare loop maybe coupled to the distal ends of the bars. The constricting element maybe movably coupled to the bars, such that the constricting element expands the snare loop when positioned at the proximal end of the plurality of bars while the constricting element collapses the snare loop when positioned at the distal end of the plurality of bars, thus, keeping the distal end of the snare loop stationary with respect to the tissue.

Abstract: A medical device for resecting tissue. The medical device is slidably disposed within a working channel of an elongate introduction sheath. The medical device includes an elongate shaft having a proximal end, a distal end, and a lumen extending therebetween. The distal end of the elongate shaft may include an opening in communication with the lumen. In addition, the medical device includes a support structure having a slot extending along an inner surface of the support structure in communication with the lumen of the elongate shaft. The medical device further includes a snare loop having a first position disposed within the slot of the support structure, and a second position disposed within the lumen of the elongate shaft. An actuation member is slidably disposed within the lumen of the elongate shaft and is connected to the snare loop.

Abstract: A device for tissue resection and methods of using the same is disclosed, including a snare loop and a tubular handle. The snare loop has both conductive and insulated portions such that the snare loop can be used to cut tissue selectively to make perimeter cuts on the tissue to be resected. The snare loop may be placed and tightened on a target tissue and may be activated for cutting the tissue to be resected by passing an electrical current through the snare loop. Some embodiments of the device include a hood and cutting wire for making perimeter cuts on the tissue to be resected.

Abstract: A medical device may include a housing. The housing may include an outer wall, an inner wall spaced from the outer wall, and a cavity between the outer wall and the inner wall. The cavity may be in fluid communication with a lumen configured to adjust pressure within the cavity. The medical device may also include a cutting tool configured to move from extending around an outer surface of the housing to entering the cavity of the housing.