Patents by Inventor Samuel V. AGRESTA

Samuel V. AGRESTA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20240132474
    Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.
    Type: Application
    Filed: May 8, 2023
    Publication date: April 25, 2024
    Inventors: Samuel V. Agresta, Chong-Hui Gu, David Schenkein, Hua Yang, Liting Guo, Zhen Tang, Jianming Wang, Yanfeng Zhang, Yan Zhou
  • THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20230277514
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using an inhibitor of a mutant IDH1 enzyme.
    Type: Application
    Filed: May 8, 2023
    Publication date: September 7, 2023
    Inventor: Samuel V. Agresta
  • Combination therapy for treating malignancies
    Patent number: 11419859
    Abstract: Provided are methods and compositions for treating acute myelogenous leukemia (AML) in patients carrying an IDH1 mutation using an inhibitor of a mutant IDH1 enzyme, (S)—N—((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide in combination with cytarabine and doxorubicin or idarubicin as an induction therapy and either cytarabine or a combination of combination of mitoxantrone and etoposide as consolidation therapy.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: August 23, 2022
    Assignee: SERVIER PHARMACEUTICALS LLC
    Inventor: Samuel V. Agresta
  • METHODS OF USING PYRUVATE KINASE ACTIVATORS
    Publication number: 20220211697
    Abstract: Described herein are methods for using compounds that activate pyruvate kinase.
    Type: Application
    Filed: December 15, 2021
    Publication date: July 7, 2022
    Inventors: Samuel V. Agresta, Yue Chen, Marvin Barry Cohen, Lenny Dang, Charles Kung, Elizabeth A. Merica, Bruce Alan Silver, Hua Yang
  • Methods of using pyruvate kinase activators
    Patent number: 11234976
    Abstract: Described herein are methods for using compounds that activate pyruvate kinase.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 1, 2022
    Assignee: Agios Pharmaceuticals, Inc.
    Inventors: Samuel V. Agresta, Yue Chen, Marvin B. Cohen, Lenny Dang, Charles Kung, Elizabeth A. Merica, Bruce A. Silver, Hua Yang
  • COMBINATION THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20210386749
    Abstract: Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.
    Type: Application
    Filed: December 24, 2020
    Publication date: December 16, 2021
    Inventor: Samuel V. Agresta
  • THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20210205281
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using an inhibitor of a mutant IDH1 enzyme.
    Type: Application
    Filed: March 16, 2021
    Publication date: July 8, 2021
    Inventor: Samuel V. Agresta
  • THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20210155603
    Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.
    Type: Application
    Filed: June 29, 2020
    Publication date: May 27, 2021
    Inventors: Samuel V. Agresta, Chong-Hui Gu, David Schenkein, Hua Yang, Liting Guo, Zhen Tang, Jianming Wang, Yanfeng Zhang, Yan Zhou
  • Therapy for treating malignancies
    Patent number: 10980788
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using an inhibitor of a mutant IDH1 enzyme.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 20, 2021
    Assignee: Agios Pharmaceuticals, Inc.
    Inventor: Samuel V. Agresta
  • COMBINATION THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20210100805
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and a DNA demethylating agent.
    Type: Application
    Filed: May 21, 2020
    Publication date: April 8, 2021
    Inventors: Vivek Saroj Kumar Chopra, Jorge DiMartino, Laurie A. Kenvin, Robert Douglas Knight, Kyle MacBerth, Krishnan Viswanadhan, Qiang Xu, Samuel V. Agresta
  • Combination therapy for treating malignancies
    Patent number: 10905692
    Abstract: Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: February 2, 2021
    Assignee: Agios Pharmaceuticals, Inc.
    Inventor: Samuel V. Agresta
  • COMBINATION THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20200405737
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using a combination of an inhibitor of a mutant IDH1 enzyme and a DNA demethylating agent.
    Type: Application
    Filed: April 13, 2020
    Publication date: December 31, 2020
    Inventors: Samuel V. Agresta, Krishnan Viswanadhan, Jorge Dimartino, Vivek Saroj Kumar Chopra, Kyle J. Macbeth, Robert Douglas Knight, Laurie Kenvin, Qiang Xu
  • Therapeutically active compounds and their methods of use
    Patent number: 10730854
    Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: August 4, 2020
    Assignee: Agios Pharmaceuticals, Inc.
    Inventors: Samuel V. Agresta, Chong-Hui Gu, David Schenkein, Hua Yang, Liting Guo, Zhen Tang, Jianming Wang, Yanfeng Zhang, Yan Zhou
  • Combination therapy for treating malignancies
    Patent number: 10695352
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and a DNA demethylating agent.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: June 30, 2020
    Assignees: Celgene Corporation, Agios Pharmaceuticals, Inc.
    Inventors: Vivek Saroj Kumar Chopra, Jorge DiMartino, Laurie A. Kenvin, Robert Douglas Knight, Kyle MacBeth, Krishnan Viswanadhan, Qiang Xu, Samuel V. Agresta
  • Combination therapy for treating malignancies
    Patent number: 10653710
    Abstract: Provided are methods and compositions for treating hematological malignancies in patients carrying an IDH1 mutation using a combination of an inhibitor of mutant IDH1 enzyme, (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide, or a pharmaceutically acceptable salt thereof (COMPOUND 2) and a DNA demethylating agent.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 19, 2020
    Assignees: Agios Pharmaceuticals, Inc., Celgene Corporation
    Inventors: Samuel V. Agresta, Krishnan Viswanadhan, Jorge DiMartino, Vivek Saroj Kumar Chopra, Kyle J. MacBeth, Robert Douglas Knight, Laurie Kenvin, Qiang Xu
  • METHODS OF USING PYRUVATE KINASE ACTIVATORS
    Publication number: 20200030322
    Abstract: Described herein are methods for using compounds that activate pyruvate kinase.
    Type: Application
    Filed: June 10, 2016
    Publication date: January 30, 2020
    Applicant: Agios Pharmaceuticals, Inc.
    Inventors: Samuel V. Agresta, Yue Chen, Marvin B. Cohen, Lenny Dang, Charles Kung, Elizabeth A. Merica, Bruce A. Silver, Hua Yang
  • THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20190374522
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using an inhibitor of a mutant IDH1 enzyme.
    Type: Application
    Filed: June 7, 2019
    Publication date: December 12, 2019
    Inventor: Samuel V. Agresta
  • THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20180370951
    Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.
    Type: Application
    Filed: September 4, 2018
    Publication date: December 27, 2018
    Inventors: Samuel V. Agresta, Chong-Hui Gu, David Schenkein, Hua Yang, Liting Guo, Zhen Tang, Jianming Wang, Yanfeng Zhang, Yan Zhou
  • COMBINATION THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20180311249
    Abstract: Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.
    Type: Application
    Filed: October 14, 2016
    Publication date: November 1, 2018
    Inventor: Samuel V. Agresta
  • COMBINATION THERAPY FOR TREATING MALIGNANCIES
    Publication number: 20180303808
    Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using a combination of an inhibitor of a mutant IDH1 enzyme and an AML induction and consolidation therapy.
    Type: Application
    Filed: October 14, 2016
    Publication date: October 25, 2018
    Inventor: Samuel V. Agresta