Patents by Inventor Samuil R. Umansky

Samuil R. Umansky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
    Patent number: 11149313
    Abstract: The invention is directed to methods for diagnosis and differentiation of neurodegenerative diseases (NDs), by quantifying miRNAs in bodily fluids.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: October 19, 2021
    Assignee: DIAMIR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir G. Tsivinsky
  • Methods of using miRNAs from bodily fluids for detection and monitoring of Parkinson's disease (PD)
    Patent number: 11098362
    Abstract: The invention is directed to methods for early diagnosis, progression and treatment monitoring of Parkinson's disease (PD) and its differentiation from other neurodegenerative diseases by quantifying brain-enriched miRNA in bodily fluids.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: August 24, 2021
    Assignee: DIAMIR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir G. Tsivinsky
  • Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
    Patent number: 10975436
    Abstract: The invention provides methods for diagnosis and monitoring of Rett syndrome and other neurodevelopmental disorders by quantitative analysis of miRNAs in bodily fluids.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: April 13, 2021
    Assignee: DIAMIR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir G. Tsivinsky
  • miRNA-based methods for detecting and monitoring aging
    Patent number: 10781487
    Abstract: The present invention is directed to methods for detection, treatment monitoring, and slowing of aging by quantifying miRNAs in bodily fluids.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: September 22, 2020
    Assignee: DIAMIR, LLC
    Inventors: Kira S. Sheinerman, Vladimir G. Tsivinsky, Samuil R. Umansky
  • METHODS OF DETECTING miRNA
    Publication number: 20200283851
    Abstract: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 10, 2020
    Inventors: Samuil R. UMANSKY, Hovsep MELKONYAN, Vladimir SCHEINKER
  • miRNA-based universal screening test (UST)
    Patent number: 10472681
    Abstract: Described are methods for early noninvasive or minimally invasive detection of pathological changes in organ systems/organs/tissues/cells by quantifying organ system-/organ-/tissue-/cells type-enriched miRNA in bodily fluids.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: November 12, 2019
    Assignee: DIAMIR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir Tsivinsky
  • Methods of using miRNA from bodily fluids for early detection and monitoring of mild cognitive impairment (MCI) and Alzheimer's disease (AD)
    Patent number: 10246747
    Abstract: Described are methods for early diagnosis and progression monitoring of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) by quantifying neurite and/or synapse miRNAs in bodily fluids.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: April 2, 2019
    Assignee: DiamiR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir Tsivinsky
  • METHODS OF USING MIRNAS FROM BODILY FLUIDS FOR DETECTION AND DIFFERENTIATION OF NEURODEGENERATIVE DISEASES
    Publication number: 20190093167
    Abstract: The invention is directed to methods for diagnosis and differentiation of neurodegenerative diseases (NDs), by quantifying miRNAs in bodily fluids.
    Type: Application
    Filed: March 21, 2017
    Publication date: March 28, 2019
    Applicant: DIAMIR, LLC
    Inventors: Samuil R. UMANSKY, Kira S. SHEINERMAN, Vladimir G. TSIVINSKY
  • miRNA-BASED METHODS FOR DETECTING AND MONITORING AGING
    Publication number: 20190024169
    Abstract: The present invention is directed to methods for detection, treatment monitoring, and slowing of aging by quantifying miRNAs in bodily fluids.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 24, 2019
    Applicant: DiamiR, LLC
    Inventors: Kira S. Sheinerman, Vladimir G. Tsivinsky, Samuil R. Umansky
  • METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS
    Publication number: 20180312925
    Abstract: The invention provides methods for diagnosis and monitoring of Rett syndrome and other neurodevelopmental disorders by quantitative analysis of miRNAs in bodily fluids.
    Type: Application
    Filed: July 5, 2018
    Publication date: November 1, 2018
    Applicant: DiamiR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir G. Tsivinsky
  • METHODS OF DETECTING miRNA
    Publication number: 20180135126
    Abstract: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.
    Type: Application
    Filed: January 6, 2017
    Publication date: May 17, 2018
    Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Vladimir S. Scheinker
  • Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media
    Patent number: 9909118
    Abstract: This invention provides compositions and methods for rapid separation, isolation and purification of nucleic acids from biological samples using anionic exchange media. The method can utilize commercially available strong or weak anion exchanger materials with selected solutions of known ionic strength for adsorption and elution. The instant method is particularly advantageous as it permits the purification and identification of shorter fragments of nucleic acids from bodily fluids which, until now, had not been identified.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 6, 2018
    Assignee: Trovagene, Inc.
    Inventors: Samuil R Umansky, Hovsep S Melkonyan, Erik Meyer, William John Feaver
  • miRNA-BASED UNIVERSAL SCREENING TEST (UST)
    Publication number: 20170362656
    Abstract: Described are methods for early noninvasive or minimally invasive detection of pathological changes in organ systems/organs/tissues/cells by quantifying organ system-/organ-/tissue-/cells type-enriched miRNA in bodily fluids.
    Type: Application
    Filed: May 26, 2017
    Publication date: December 21, 2017
    Applicant: DIAMIR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir Tsivinsky
  • Amplification and sequencing of transrenal nucleic acids
    Patent number: 9816148
    Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: November 14, 2017
    Assignee: Trovagene, Inc.
    Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman
  • miRNA-based universal screening test (UST)
    Patent number: 9803242
    Abstract: Described are methods for early noninvasive or minimally invasive detection of pathological changes in organ systems/organs/tissues/cells by quantifying organ system-/organ-/tissue-/cells type-enriched miRNA in bodily fluids.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: October 31, 2017
    Assignee: DiamiR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir Tsivinsky
  • METHODS OF USING miRNA FROM BODILY FLUIDS FOR EARLY DETECTION AND MONITORING OF MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD)
    Publication number: 20170107575
    Abstract: Described are methods for early diagnosis and progression monitoring of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) by quantifying neurite and/or synapse miRNAs in bodily fluids.
    Type: Application
    Filed: December 23, 2016
    Publication date: April 20, 2017
    Applicant: DiamiR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir Tsivinsky
  • Methods of using miRNA from bodily fluids for early detection and monitoring of mild cognitive impairment (MCI) and alzheimer's disease (AD)
    Patent number: 9556487
    Abstract: Described are methods for early diagnosis and progression monitoring of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) by quantifying neurite and/or synapse miRNAs in bodily fluids.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: January 31, 2017
    Assignee: DIAMIR, LLC
    Inventors: Samuil R. Umansky, Kira S. Sheinerman, Vladimir Tsivinsky
  • METHOD FOR DETECTION OF HUMAN PAPILLOMAVIRUS
    Publication number: 20170016078
    Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.
    Type: Application
    Filed: July 25, 2016
    Publication date: January 19, 2017
    Applicant: Trovagene, Inc.
    Inventors: Hovsep S. Melkonyan, Samuil R. Umansky, Zhenghan Xin
  • Method for detection of high risk human papillomavirus
    Patent number: 9453265
    Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: September 27, 2016
    Assignee: Trovagene, Inc.
    Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Zhenghan M. Xin
  • Amplification and Sequencing of Transrenal Nucleic Acids
    Publication number: 20160060717
    Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.
    Type: Application
    Filed: May 20, 2013
    Publication date: March 3, 2016
    Applicant: TROVAGENE, INC.
    Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman