Abstract: A microfluidic device (100) is disclosed for in-process monitoring of cell culture conditions including for example one or more of: cell density; cell viability; secreted proteins; protein analysis; epitope markers; concentrations of metabolites or nutrients and antigenic determinations; the device comprising: a cell inlet path (120); plural fluid reservoirs (130) in fluid communication with the cell input path, a cell analysis area (160) in fluid communication with the path and reservoirs, and a waste storage volume (166) also in fluid communication with the cell analysis area, the device being operable to cause a primary fluid flow along the inlet path to the analysis area, and to selectively cause secondary fluid flow(s) into the path from none, one or more of the selected reservoirs to combine, if one or more of the reservoirs are selected, with the primary fluid flow from the cell inlet path, in each case for analysis at the cell analysis area, the device being further operable to cause a fluid flow of t

Abstract: The present disclosure is for a tool for measurement of phases in fluid in downhole applications. The tool includes a light coupler for providing a first light and for detecting a second light. The first light is provided to an optical interface and the second light is received from the optical interface. The optical interface is between the tool and the fluid. An optical path is provided that is integral or coupled to the optical interface. The optical path allows transmission of the first light into the fluid at the optical interface and also allows receiving the second light from the optical interface. The second light includes one or more light components disturbed by the fluid. A processor provides digital data associated with the measurement of phases in the fluid using optical data from at least the second light.

Abstract: A system for detecting an array of samples having detectable samples and at least one reference sample is provided. The system comprises an electromagnetic radiation source, a sensing surface comprising a plurality of sample fields, wherein the plurality of sample fields comprise at least one reference field, a phase difference generator configured to introduce differences in pathlengths of one or more samples in the array of samples, and an imaging spectrometer configured to image one or more samples in the array of samples.

Abstract: A method includes receiving a gas mixture at a first pressure including at least a primary gas and a secondary gas and changing a pressure of the received gas mixture from the first pressure to a second pressure. Further, the method includes determining a spectra of the gas mixture at the second pressure, wherein at least the first spectral line of the primary gas is spectrally distinguished from at least the second spectral line of the secondary gas, identifying a peak wavelength associated with the spectrally distinguished first spectral line of the primary gas based on at least two wavelengths of the secondary gas corresponding to at least two peak amplitudes in the spectra of the gas mixture, and determining a concentration of the primary gas based on the identified peak wavelength associated with the spectrally distinguished first spectral line of the primary gas.

Abstract: A method implemented on a processor includes emitting a light beam from a light source to a component in an absorption cell, wherein the light beam comprises a plurality of wavelength beams. The method further includes generating a plurality of response signals due to the presence of the component, corresponding to the plurality of wavelength beams of the light beam. The method also includes detecting the plurality of response signals by a photo detector coupled to the absorption cell. The method includes determining a concentration of the component based on the plurality of response signals.

Abstract: A system, comprising at least one source for irradiating electromagnetic radiation into a sample fluid and a reference fluid resulting in a change in a temperature of the sample fluid and a change in a temperature of the reference fluid, and a processing subsystem that monitors and determines a concentration of a gas of interest dissolved in the sample fluid based upon a difference between the change in the temperature of the sample fluid and the change in the temperature of the reference fluid, wherein the reference fluid does not contain the gas of interest, and the electromagnetic radiation has a wavelength range corresponding to a spectral absorption range of the gas of interest.

Abstract: A method for dissolved gas analysis is presented. The method includes the steps of irradiating a fluid with electromagnetic radiation; and determining a concentration of a gas as a function of a temperature change of the fluid in response to the irradiation. A device for such an analysis of dissolved gases in a fluid, and a system having such device are also described.

Abstract: A method for detecting of components in a fluid includes emitting a modulated light beam from a modulated light source to the fluid in a chamber, wherein the fluid comprises a liquid and a component in the liquid. The method includes producing an acoustic signal in response to the emitted modulated light beam and detecting the acoustic signal via a pressure sensor disposed in the chamber. The method in one example also includes transmitting the acoustic signal from the pressure sensor to a processor based module and determining at least one of a component and a concentration of the component in the fluid via the processor based module, based on the acoustic signal.

Abstract: A system is presented. The system includes an absorption cell filled-with a gas-mixture, a mirror-cum-window comprising a first portion that acts as a first mirror and a second portion that acts as a first window, a second mirror, a plurality of radiation sources to generate a plurality of light beams directed into the absorption cell through the first window followed by reflection of the plurality of light beams between the first mirror and the second mirror to irradiate the gas-mixture resulting in generation of a plurality of transmitted light beams passing out of the absorption cell through the second window, a detector that detects at least one characteristic of the plurality of transmitted light beams resulting in generation of one or more response signals, and a processing subsystem that analyzes the gas-mixture at least based on the one or more response signals.

Abstract: A method for determining a concentration of at least one individual gas present in a gas-mixture includes irradiating a first component by incident modulated-light-beams characterized by a determined absorption wavelength range, modulation frequencies and a modulation amplitudes to generate first transmitted-light-beams, irradiating a second component, comprising a determined concentration of the at least one individual gas, by the first incident modulated-light-beams to generate second transmitted-light-beams, generating noise signals representative of a characteristic of the first transmitted-light-beams, generating noise-free signals representative of a characteristic of the second transmitted-light-beams, selecting an optimal modulation frequency and an optimal modulation amplitude from the modulation frequencies and the modulation amplitudes based on the noise signals and the noise-free signals, and determining a concentration of the at least one individual gas in the gas-mixture based on the optimal mod

Abstract: A device is presented. The device includes an electromagnetic guiding device to provide electromagnetic radiation, a reflector that reflects a portion of the electromagnetic radiation to generate a reflected portion of the electromagnetic radiation, wherein the reflector is fully immersed in a multiphase fluid, and a processing subsystem that analyzes the multiphase fluid based upon at least a portion of the reflected portion of the electromagnetic radiation, wherein a principal optical axis of the electromagnetic guiding device substantially aligns with a principal optical axis of the reflector.

Abstract: Provided is a laser system that includes a laser head having a laser holder configured to house a laser beam and a lens for reflecting the laser beam at a predetermined wavelength, and a thermal-mechanical adjustment device disposed on the laser head and configured to adjust a temperature and an alignment of the laser beam, to maintain the predetermined wavelength of the laser beam.

Abstract: A multimode detection system for detecting one or more samples is provided. The detection system comprises an electromagnetic radiation source, a reference arm, and a sample arm comprising a sensing substrate having a plurality of sample fields, wherein the sample fields are configured to receive the one or more samples. The system further comprises a phase difference generator configured to introduce pathlength differences in the reference arm, sample arm, or both, a spatial light modulator operatively coupled to the reference arm, sample arm, or both, wherein the spatial light modulator is configured to modulate incident radiation, resultant radiation, or both in the reference arm, sample arm, or both, and an imaging spectrometer configured to discriminate between two or more spatially separated sample en two or more spatially separated sample fields.

Abstract: A system, comprising at least one source for irradiating electromagnetic radiation into a sample fluid and a reference fluid resulting in a change in a temperature of the sample fluid and a change in a temperature of the reference fluid, and a processing subsystem that monitors and determines a concentration of a gas of interest dissolved in the sample fluid based upon a difference between the change in the temperature of the sample fluid and the change in the temperature of the reference fluid, wherein the reference fluid does not contain the gas of interest, and the electromagnetic radiation has a wavelength range corresponding to a spectral absorption range of the gas of interest.

Abstract: A method includes receiving a gas mixture at a first pressure including at least a primary gas and a secondary gas and changing a pressure of the received gas mixture from the first pressure to a second pressure. Further, the method includes determining a spectra of the gas mixture at the second pressure, wherein at least the first spectral line of the primary gas is spectrally distinguished from at least the second spectral line of the secondary gas, identifying a peak wavelength associated with the spectrally distinguished first spectral line of the primary gas based on at least two wavelengths of the secondary gas corresponding to at least two peak amplitudes in the spectra of the gas mixture, and determining a concentration of the primary gas based on the identified peak wavelength associated with the spectrally distinguished first spectral line of the primary gas.

Abstract: A gas detector and method are presented. The gas detector includes a launcher unit for coupling and merging light beams in mid-infrared and infrared wavelength ranges into a single light beam and directing the merged single light beam towards a gas flow path; a receiver unit for generating at least one photo detector current signal based on the light beam transmitted through the gas flow path; and a control unit for processing at least one photo detector current signal to measure concentration of the at least two gases present in the gas flow path.

Abstract: A gas detector and method are presented. The gas detector includes a launcher unit for coupling and merging light beams in mid-infrared and infrared wavelength ranges into a single light beam and directing the merged single light beam towards a gas flow path; a receiver unit for generating at least one photo detector current signal based on the light beam transmitted through the gas flow path; and a control unit for processing at least one photo detector current signal to measure concentration of the at least two gases present in the gas flow path.

Abstract: A system is presented. The system includes an absorption cell filled-with a gas-mixture, a mirror-cum-window comprising a first portion that acts as a first mirror and a second portion that acts as a first window, a second mirror, a plurality of radiation sources to generate a plurality of light beams directed into the absorption cell through the first window followed by reflection of the plurality of light beams between the first mirror and the second mirror to irradiate the gas-mixture resulting in generation of a plurality of transmitted light beams passing out of the absorption cell through the second window, a detector that detects at least one characteristic of the plurality of transmitted light beams resulting in generation of one or more response signals, and a processing subsystem that analyzes the gas-mixture at least based on the one or more response signals.

Abstract: A system, comprising at least one source for irradiating electromagnetic radiation into a sample fluid and a reference fluid resulting in a change in a temperature of the sample fluid and a change in a temperature of the reference fluid, and a processing subsystem that monitors and determines a concentration of a gas of interest dissolved in the sample fluid based upon a difference between the change in the temperature of the sample fluid and the change in the temperature of the reference fluid, wherein the reference fluid does not contain the gas of interest, and the electromagnetic radiation has a wavelength range corresponding to a spectral absorption range of the gas of interest.

Abstract: A method for determining a concentration of at least one individual gas present in a gas-mixture includes irradiating a first component by incident modulated-light-beams characterized by a determined absorption wavelength range, modulation frequencies and a modulation amplitudes to generate first transmitted-light-beams, irradiating a second component, comprising a determined concentration of the at least one individual gas, by the first incident modulated-light-beams to generate second transmitted-light-beams, generating noise signals representative of a characteristic of the first transmitted-light-beams, generating noise-free signals representative of a characteristic of the second transmitted-light-beams, selecting an optimal modulation frequency and an optimal modulation amplitude from the modulation frequencies and the modulation amplitudes based on the noise signals and the noise-free signals, and determining a concentration of the at least one individual gas in the gas-mixture based on the optimal mod