Patents by Inventor Sandra Steiner

Sandra Steiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS
    Publication number: 20260109689
    Abstract: The invention relates to novel compounds having the general formula I wherein A, R1, R2 and n are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 16, 2025
    Publication date: April 23, 2026
    Applicant: Hoffmann-La Roche Inc.
    Inventors: David BON, Lea Aurelie BOUCHE, Wolfgang GUBA, Emma HARGRAVE, Georg Stefan JAESCHKE, Heather Jennifer Johnston, Stefanie Katharina MESCH, Christian SCHNIDER, Sandra STEINER, Andreas Michael TOSSTORFF
  • NOVEL COMPOUNDS
    Publication number: 20260092073
    Abstract: The invention relates to novel compounds having the general formula I wherein R1, R2, R9, A1, Rx and Ry are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 15, 2025
    Publication date: April 2, 2026
    Applicant: Hoffmann-La Roche Inc.
    Inventors: David BON, Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Angélique PATINY-ADAM, Christian SCHNIDER, Jonathan Martin SHANNON, Sandra STEINER, Andreas Michael TOSSTORFF
  • NOVEL COMPOUNDS
    Publication number: 20260092076
    Abstract: The invention relates to novel compounds having the general formula I wherein R1, R2, R3, A and W are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 7, 2025
    Publication date: April 2, 2026
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lewis Scott AITKEN, Lea Aurelie BOUCHE, Wolfgang GUBA, Georg Stefan JAESCHKE, Stefanie Katharina MESCH, Christian SCHNIDER, Jonathan Martin SHANNON, Sandra STEINER
  • NOVEL COMPOUNDS
    Publication number: 20260015353
    Abstract: The invention relates to novel compounds having the general formula (I), wherein R1, R2, R3, R4 and W are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: July 19, 2023
    Publication date: January 15, 2026
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Angélique PATINY-ADAM, Christian SCHNIDER, Sandra STEINER, Andreas Michael TOSSTORFF
  • EGFR inhibitors for the treatment of cancer
    Patent number: 12479849
    Abstract: The application relates to (106) specific heterocyclic compounds comprising a thiazole ring, an indazol and a 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole system, to pharmaceutical compositions containing them and their medical use. The compounds are described as selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants and thus useful for the treatment of cancer, in particular non-small cell lung cancer.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: November 25, 2025
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Cosimo Dolente, Annick Goergler, David Hewings, Georg Jaeschke, Bernd Kuhn, Yvonne Alice Nagel, Christa Ulrike Obst-Sander, Antonio Ricci, Daniel Rueher, Sandra Steiner
  • NOVEL COMPOUNDS
    Publication number: 20250353830
    Abstract: The invention relates to novel compounds having the general formula (Ib) or (Ib?), (Ib) or (Ib?) wherein R1, R2, R6, A3, A4, A5, X, Y and W are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 1, 2023
    Publication date: November 20, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Andreas MARX, Stefanie Katharina MESCH, Angélique PATINY-ADAM, Christian SCHNIDER, Sandra STEINER, Andreas Michael TOSSTORFF
  • NEW INDAZOLE DERIVATIVES
    Publication number: 20250313565
    Abstract: The invention provides novel compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as described herein. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: May 11, 2023
    Publication date: October 9, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Georg JAESCHKE, Bruno MARTOGLIO, Yvonne Alice NAGEL, Christa Ulrike OBST-SANDER, Antonio RICCI, Sandra STEINER
  • Compounds
    Patent number: 12421209
    Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R2, R3, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.
    Type: Grant
    Filed: February 25, 2025
    Date of Patent: September 23, 2025
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lea Aurelie Bouche, Wolfgang Guba, Georg Jaeschke, Stefanie Katharina Mesch, Angelique Patiny-Adam, Christian Schnider, Sandra Steiner, Andreas Michael Tosstorff
  • EGFR INHIBITOR FOR THE TREATMENT OF CANCER
    Publication number: 20250289824
    Abstract: The invention provides novel a compound having the general formula (I) as described herein, compositions including the compound and methods of using the compound.
    Type: Application
    Filed: May 28, 2025
    Publication date: September 18, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Cosimo DOLENTE, Annick GOERGLER, David HEWINGS, Georg JAESCHKE, Bernd KUHN, Yvonne Alice NAGEL, Christa Ulrike OBST-SANDER, Antonio RICCI, Daniel RUEHER, Sandra STEINER
  • COMPOUNDS
    Publication number: 20250276958
    Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R2, R3, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 16, 2025
    Publication date: September 4, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Angelique PATINY-ADAM, Christian SCHNIDER, Sandra STEINER, Andreas Michael TOSSTORFF
  • EGFR inhibitor for the treatment of cancer
    Patent number: 12344613
    Abstract: The application relates to a compound of formula (I) containing a thiazole ring, an indazol ring and a 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole ring system, to pharmaceutical compositions containing it and its medical use. The compounds are described as selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants and thus useful for the treatment of cancer, in particular non-small cell lung cancer.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: July 1, 2025
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Cosimo Dolente, Annick Goergler, David Hewings, Georg Jaeschke, Bernd Kuhn, Yvonne Alice Nagel, Christa Ulrike Obst-Sander, Antonio Ricci, Daniel Rueher, Sandra Steiner
  • NOVEL COMPOUNDS
    Publication number: 20250197370
    Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R2, R3, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: February 25, 2025
    Publication date: June 19, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Angelique PATINY-ADAM, Christian SCHNIDER, Sandra STEINER, Andreas Michael TOSSTORFF
  • Isoindolinone derivatives as selective allosteric inhibitors of Egfr mutant cancers
    Patent number: 12209091
    Abstract: The present invention provides compounds which are selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: January 28, 2025
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Duplessis, Annick Goergler, Georg Jaeschke, Buelent Kocer, Bernd Kuhn, Kiel Lazarski, Yanke Liang, Yvonne Alice Nagel, Ulrike Obst Sander, Antonio Ricci, Daniel Rueher, Sandra Steiner
  • HETEROCYCLIC NLRP3 INHIBITORS
    Publication number: 20240409553
    Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R1b, R2, R3, and Z are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 15, 2024
    Publication date: December 12, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lewis Scott AITKEN, Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Sandra STEINER, Andreas Michael TOSSTORFF
  • PYRIDAZINE DERIVATIVES AS INHIBITORS OF NLRP3
    Publication number: 20240308977
    Abstract: The invention relates to novel compounds having the general formula Ib wherein RX, RY and Z is described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 16, 2024
    Publication date: September 19, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lewis Scott AITKEN, Thomas Alexander ALANINE, Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Stephen Malcom THOM, Andreas Michael TOSSTORFF, Sabrina HERR, Christian SCHNIDER, Sandra STEINER
  • FUSED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS NLRP3 INHIBITORS
    Publication number: 20240279237
    Abstract: The invention relates to novel compounds having the general formula Ic wherein R1, R2, R3, R8, R9, RX, A1, A2, W and n are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 17, 2024
    Publication date: August 22, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lewis Scott AITKEN, Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Heather Jennifer JOHNSTON, Stefanie Katharina MESCH, Angélique PATINY-ADAM, Christian SCHNIDER, Jonathan Martin SHANNON, Sandra STEINER, Andreas TOSSTORFF
  • NOVEL COMPOUNDS
    Publication number: 20240132471
    Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R2, R1, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 30, 2023
    Publication date: April 25, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Angélique PATINY-ADAM, Christian SCHNIDER, Sandra STEINER, Andreas Michael TOSSTORFF
  • Isoxazolyl ether derivatives as GABA?5 PAM
    Patent number: 11840528
    Abstract: The invention provides novel compounds having the general formula (I) or (II) wherein R2, R3, R5, R99, W, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: December 12, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Giuseppe Cecere, Katrin Groebke Zbinden, Maria-Clemencia Hernandez, Henner Knust, Andreas Koblet, Andres Miguel Olivares Morales, Angélique Patiny-Adam, Emmanuel Pinard, Valerie Runtz-Schmitt, Sandra Steiner
  • 2-benzopyrazinyl-n-heteroaryl-2-phenyl-acetamide compounds
    Patent number: 11708354
    Abstract: The present invention provides compounds which are selective allosteric inhibitors of T790M and C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: July 25, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Duplessis, Georg Jaeschke, Bernd Kuhn, Kiel Lazarski, Yanke Liang, Yvonne Alice Nagel, Antonio Ricci, Daniel Rueher, Sandra Steiner
  • EGFR INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20230054473
    Abstract: The application relates to (106) specific heterocyclic compounds comprising a thiazole ring, an indazol and a 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole system, to pharmaceutical compositions containing them and their medical use. The compounds are described as selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants and thus useful for the treatment of cancer, in particular non-small cell lung cancer.
    Type: Application
    Filed: June 19, 2020
    Publication date: February 23, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Cosimo DOLENTE, Annick GOERGLER, David HEWINGS, Georg JAESCHKE, Bernd KUHN, Yvonne Alice NAGEL, Christa Ulrike OBST-SANDER, Antonio RICCI, Daniel RUEHER, Sandra STEINER