Abstract: The present invention relates to a composition for the treatment and improvement of diabetes comprising caveolin as an active ingredient and a method for treating diabetes using the same, more precisely a composition comprising caveolin-1 as an active ingredient for the treatment and improvement of type II diabetes which is age-dependent but not showing obesity symptom and a method for treating diabetes using the same. The treatment method and composition of the present invention is very effective in improving and treating diabetes by regulating insulin sensitivity by increasing caveolin level in muscle tissues of type II diabetes patient which is age-dependent but not showing obesity symptom.

Abstract: The present invention relates to a composition for inhibiting cellular senescence, comprising N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methanesulfonamide. During the progression of cellular senescence, the expression of COX-2 was decreased, whereas the enzymatic activity of COX-2 was increased, and the cellular senescence regulatory effects of the three selective COX-2 inhibitors had no connection with the concentration of intracellular reactive oxygen species, the activity of NF-?B and the amounts of p53 and p21 proteins. Rather, it was found that the three selective COX-2 inhibitors regulated the expression of caveolin-1 at the transcriptional level and regulated the intracellular total cholesterol concentration, and these results were closely connected with the cellular senescence regulatory effects of the three selective COX-2 inhibitors.

Abstract: A clutch actuator assembly may include a motor provided with a rotatable worm shaft, a screw thread being formed at an exterior circumference of the worm shaft; a worm wheel having a disk shape, and provided with a worm gear engaged to the screw thread and first and second guiding holes; an operation unit mounted in the first and second guiding holes in order to move toward a radial direction of the worm wheel; and an upper body provided with a fork, and engaging or releasing a clutch by upward and downward movements of the fork corresponding to a movement of the operation unit.

Abstract: A clutch actuator is configured to change operational force applied to a clutch in cases that a worm wheel is rotated by a motor. The clutch actuator may include a motor provided with a rotatable worm shaft, a screw thread formed along an exterior circumference of the worm shaft, a worm wheel provided with a worm gear engaging the screw thread, and a cam recess, an operation rod mounted to the worm wheel, the operation rod configured to engage or release a clutch, and/or a rotatable operation unit disposed within the cam recess, and configured to apply elastic force to the worm wheel. Methods of using the clutch actuator are also described.

Abstract: The present application discloses a therapeutic antimicrobial composition comprising mucocidin antimicrobial peptides or analogue or fragments thereof having antimicrobial activity.

Abstract: The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an inhibitor of adenylyl cyclase or an inhibitor of protein kinase A.

Abstract: The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an inhibitor of adenylyl cyclase or an inhibitor of protein kinase A.

Abstract: The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.

Abstract: The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.

Abstract: A liquid crystal display device that uses in-plane switching is capable of eliminating a stain generated at an outer area of a thin film transistor array and minimizing a time delay of a common voltage applied to a thin film transistor array. In the device, a plurality of data lines apply data signals to a thin film transistor array. A plurality of gate lines apply gate signals to the thin film transistor array. A plurality of common voltage lines apply a common voltage to the thin film transistor array. The common voltage lines are provided at the outer area of the thin film transistor array and are spaced from the thin film transistor array by a distance of more than 1 to 1.5 mm. A plurality of dummy signal lines are arranged in parallel to the common voltage lines and adjacent to the common voltage lines provided at the outer area of the thin film transistor array to apply alternating current signals.

Abstract: The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different polynucleotide sequences in a sample.

Abstract: The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different polynucleotide sequences in a sample.

Abstract: A liquid crystal display device that uses in-plane switching is capable of eliminating a stain generated at an outer area of a thin film transistor array and minimizing a time delay of a common voltage applied to a thin film transistor array. In the device, a plurality of data lines apply data signals to a thin film transistor array. A plurality of gate lines apply gate signals to the thin film transistor array. A plurality of common voltage lines apply a common voltage to the thin film transistor array. The common voltage lines are provided at the outer area of the thin film transistor array and are spaced from the thin film transistor array by a distance of more than 1 to 1.5 mm. A plurality of dummy signal lines are arranged in parallel to the common voltage lines and adjacent to the common voltage lines provided at the outer area of the thin film transistor array to apply alternating current signals.

Abstract: The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different polynucleotide sequences in a sample.

Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.

Abstract: A multi-step process that yields a gas permeable contact lens that is more comfortable to wear due to an increased amount of moisture retention between the cornea and the lens and that also provides an increased amount of oxygen to the cornea to prevent the many potential problems occurring due to insufficient oxygen in the cornea area. The process entails exposure of the concave side of a gas permeable contact lens to far infrared light, thereby creating an electron deficiency on the concave side of the lens (the side which contacts the cornea). This electron deficiency drives a surface reaction upon the lens that produces water and oxygen as products, thereby providing the oxygen and moisture. Subsequent steps in the process are similar, although each subsequent exposure results in greater electron depletion of the concave side of the contact lens, thereby causing the contact lens to be increasingly effective in retaining moisture and oxygen with each additional exposure.

Abstract: The sequences of a pair of human proteins, trichohyalin and transglutaminase-3, in addition to the sequence of the mouse transglutaminase-3 protein, have been discovered. The enzyme transglutaminase-3 is used to cross-link the structural protein trichohyalin in order to form a gel.

Abstract: A process for preparing the interior surfaces of aquariums with debris-repellant properties, comprising the irradiation of a surface by far infrared light, thereby inducing an electron deficiency upon the surface. Dirt particles are repelled by the positively charged surface, since most dust particles have positively charged centers. The negatively charged periphery of said dust particles adhere to the positively charged surface, but the attractive forces between the surface and the dirt particles are too weak to overcome gravitational forces which cause the particles to fall off or float away from the surface. In addition, the electron deficiency on the inner surface of the aquarium drives a surface reaction which produces oxygen. This evolving of gas from the inner surface further repels the adherence of debris particles and provides a healthy atmosphere for fish dwelling in the aquarium.

Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.

Abstract: This invention relates to polymer sealant microencapsulated by polyurethane reaction and its binder solution, particularly employing threaded mechanical fasteners such as bolt-nuts, screws, pipe joints and threaded nails, etc. The microcapsules are prepared by interfacial polyurethane reaction of triisocyanate with poly-functional alcohol under the aqueous oil-droplets solution containing vinyl monomers, oligomers, redox initiators and organic solvents together as core materials of the microcapsules. The binder solution of the microcapsules is prepared by dissolving chloroprene, polyester acrylate, urethane acrylate, carboxyl- or hydroxy-modified vinylchloride-vinylacetate copolymer, coinitiators and fillers in a mixture of tetrachloroethylene and toluene.