Abstract: A method for image processing is provided. The method includes a step of collecting training data including a raw image, a two-dimensional (2D) image, and a depth image of the same object by using a data collection device, a step of learning the raw image and the 2D image to directly reconstruct a three-dimensional (3D) image from the raw image by using a diffusion network executed by a processor, based on a deep denoising learning method, and a step of updating a parameter of the diffusion network by using an update unit executed by the processor, based on a loss function representing a difference between the reconstructed 3D image and the depth image.

Abstract: A liver-targeted drug and therapeutic use thereof for diseases requiring drug action in the liver are disclosed. A method in which a substance having activity with respect to glucagon is used so as to induce delivery of the liver-targeted drug to liver tissues or an increase in distribution of the drug in liver tissues after in vivo administration.

Abstract: Provided is an apparatus for diagnosing a disease, which includes an acquisition module configured to acquire multi-modal data including at least two types of data among text data, speech data, and image data related to each depression patient, a preprocessing module configured to visualize data that is not the image data among the multi-modal data and output image datasets including the image data among the multi-modal data and the visualized data, and a classification module configured to classify whether each depression patient has depression based on the image datasets.

Abstract: A sustained release preparation of a human growth hormone conjugate is disclosed. The sustained release preparation contains a sustained release human growth hormone (hGH) conjugate resulting from conjugation between an immunoglobulin Fc region and a human growth hormone (hGH) as an active peptide; a buffer solution; a nonionic surfactant; and a sugar alcohol. A freeze dried preparation and a liquid preparation including the sustained release human growth hormone conjugate, a production method for the freeze dried preparation, a method of reconstituting the freeze dried preparation, and a kit containing the freeze dried preparation and a reconstituting solution are also disclosed.

Abstract: A liver-targeted drug and therapeutic use thereof for diseases requiring drug action in the liver are disclosed. Additionally, a method in which a substance having activity on glucagon is used so as to induce delivery of the drug to the liver tissue or an increase in distribution of the drug in the liver tissue after in vivo administration.

Abstract: The present invention relates to a lyophilized formulation including a fusion protein of ?-galactosidase A and a preparation method thereof, wherein the lyophilized formulation not only has storage stability by including a composition providing structural stability to a fusion protein of ?-galactosidase A, but also has excellent stability although the fusion protein is contained at a high concentration.

Abstract: A micro-lens array is provided. The micro-lens array includes a transparent substrate, a plurality of polarizers disposed on the transparent substrate, a passivation layer covering the plurality of polarizers, and a plurality of micro-lenses disposed on the passivation layer, wherein light reflected to an object passes through the transparent substrate, and then, is polarized based on a plurality of different polarization orientations formed by the plurality of polarizers and is incident on the plurality of micro-lenses.

Abstract: An electroluminescent display apparatus may include a pixel including a driving element having a gate electrode connected to a data line and a source electrode connected to a reference voltage line and a pixel driving circuit applying a sensing data voltage to the gate electrode of the driving element through the data line, detecting a source electrode voltage of the driving element, shifted from a sensing reference voltage based on the sensing data voltage, through the reference voltage line to obtain a detection voltage, calculating an offset voltage based on the detection voltage, and lowering a level of the sensing data voltage based on the offset voltage, in a plurality of vertical blank periods.

Abstract: An electroluminescent display apparatus may include a pixel including a driving element having a gate electrode connected to a data line and a source electrode connected to a reference voltage line and a pixel driving circuit applying a sensing data voltage to the gate electrode of the driving element through the data line, detecting a source electrode voltage of the driving element, shifted from a sensing reference voltage based on the sensing data voltage, through the reference voltage line to obtain a detection voltage, calculating an offset voltage based on the detection voltage, and lowering a level of the sensing data voltage based on the offset voltage, in a plurality of vertical blank periods.

Abstract: A semiconductor memory device includes a memory bank arranged into first through nth split regions containing at least one memory cell sub-array within each split region, and first through nth global input/output (GIO) split lines electrically coupled to the first through nth split regions. First through n-lth connection control transistors are provided, which have gate terminals responsive to respective connection control signals. The first connection control transistor is configured to electrically short the first and second GIO split lines together when enabled by a corresponding connection control signal, and the n-1th connection control transistor is configured to electrically short the n-1th and nth GIO split lines together when enabled by a corresponding connection control signal. A GIO sense amplifier is provided, which is electrically coupled to the memory bank.

Abstract: Provided are a plenoptic microscope system having a structure in which a microlens array (MLA) is installed between an object and a microscope optical system and a general microscope camera is used as an image sensor, and an image processing apparatus for performing plenoptic imaging with information acquired from the same. In the plenoptic microscope system, an MLA including at least one microlens having a number of apertures (NA) similar to that of an objective lens of a microscope optical system is positioned at the front end of an incidence part of the microscope optical system and the objective lens is positioned at a focal length of the MLA or on an image plane of the MLA. The plenoptic image processing apparatus generates Plenoptic 1.0 and/or 2.0 images.

Abstract: A semiconductor memory device is provided which is capable of adaptively controlling bias and a method of operating the same. The semiconductor memory device includes: a memory cell area including a plurality of first transistors to which a first bias voltage is applied; and a peripheral circuit area which overlaps the memory cell area in a first direction and includes a plurality of second transistors to which a second bias voltage controlled differently from the first bias voltage is applied.

Abstract: Provided are a liquid formulation of protein and a method of preparing the same. According to a liquid formulation containing a high concentrate of eflapegrastim and a method of preparing the same, the liquid formulation may have excellent solubility and stability, may have a high concentration of protein, and may be injected in a patient-friendly manner due to reduced irritation/pain at the administration site or patient discomfort.

Abstract: A semiconductor memory device includes: a memory cell array located in a first layer and including a word line, a cell bit line, and a memory cell located in a region where the word line and the cell bit line are crossed; and a bit line sense amplifier located in a second layer, different from the first layer. The bit line sense amplifier is connected to a bit line that is connected to the cell bit line and to a complementary bit line corresponding to the bit line. The bit line sense amplifier detects data stored in the at least one memory cell. Each of the at least one cell bit line is segmented into two or more portions, and the two or more portions are respectively connected to the bit line and the complementary bit line connected to the bit line sense amplifier.

Abstract: The present disclosure can effectively improve an angular image resolution and a spatial image resolution compared to the related art by solving a problem of a plenoptic image based on a microlens array according to the related art. In the case of the microlens array according to the related art, microlenses having different numerical apertures (NAs) and F # (F numbers) or focal lengths are positioned on one substrate. However, in the present disclosure, two or more microlens arrays having different NAs and F # are stacked in a layer form (all the microlenses of each microlens array are formed in the same F # and the same NA) to allow various F # and various NAs to be implemented, and thus an image of an object is formed on a sensor plane at different positions. Accordingly, a spatial resolution and a depth resolution increase.

Abstract: The present invention relates to a long-acting conjugate of an interleukin-2 analog with altered binding affinity for interleukin-2 receptors.

Abstract: A use of a fusion protein of a therapeutic enzyme and an immunoglobulin Fe region is disclosed. The fusion protein is represented by the following chemical formula 1. The fusion protein shows protective effects on peripheral sensory nerves and exhibits an extended duration in the body. Thus, the fusion protein or a composition containing the fusion protein can be used in the prevention or improvement of neuropathy.

Abstract: The present invention relates to use of a fusion protein of a therapeutic enzyme and an immunoglobulin Fc region in the prevention or improvement of renal diseases caused by or accompanied by Fabry disease.

Abstract: Modifications to interleukin-2 alpha receptors are disclosed. Interleukin-2 analogs with increased binding affinity for interleukin-2 beta receptors are disclosed.

Abstract: A liquid formulation of a long-acting conjugate of GLP-2 and a method for preparing the liquid formulation are disclosed. The liquid formulation contains 18 nmol/mL to 18,630 nmol/mL of a long-acting conjugate, a stabilizer, and a buffering agent in an amount for maintaining the pH of the liquid formulation in the range of 4.5 to 6.5.