Patents by Inventor Sang Yup Lee

Sang Yup Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220228177
    Abstract: The present invention relates to a recombinant microorganism having enhanced ability to produce lutein and a method of producing lutein using the same, and more specifically, to a recombinant microorganism having enhanced ability to produce lutein, which is obtained by modifying any one or more metabolic pathways, selected from the group consisting of a substrate tunnel, an electron tunnel, and a C5 heme production pathway, in a host cell having ability to produce lutein. Using the highly efficient lutein-producing recombinant microbial strain according to the present invention, it is possible to replace an existing lutein production method that relies on labor-intensive and inefficient plant extraction and to produce lutein in a more environmentally friendly and sustainable way.
    Type: Application
    Filed: January 13, 2022
    Publication date: July 21, 2022
    Inventors: Sang Yup LEE, Seon Young PARK
  • Publication number: 20220205000
    Abstract: The present invention relates to a recombinant microorganism imparted with increased ability to produce glutaric acid by further introducing a gene encoding a polypeptide having glutaric acid transporter activity into a microorganism having ability to produce glutaric acid, and to a method of preparing glutaric acid using the recombinant microorganism. According to the present invention, glutaric acid used for the preparation of various compounds such as polyamide, polyurethane, 1,5-pentanediol, and 5-hydroxyvaleric acid can be biosynthesized at high yield.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 30, 2022
    Inventors: Sang Yup LEE, Tae hee Han
  • Patent number: 11371068
    Abstract: The present invention relates to a microorganism variant having the ability to extracellularly produce heme, and more particularly to a metabolically engineered microorganism variant having the ability to extracellularly produce heme and a method of producing heme using the same. According to the present invention, heme, an organometallic compound which is increasingly used as a health food or food supplement for the treatment of porphyria, can be extracellularly secreted and produced in high yield using the microorganism variant, but not conventional chemical synthesis or enzymatic synthesis.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: June 28, 2022
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Yup Lee, Xin Rui Zhao, Kyeong Rok Choi
  • Publication number: 20220136028
    Abstract: Disclosed are a recombinant microorganism for producing a hydrophobic material, which is subjected to cell-membrane engineering in order to be imparted with at least one characteristic among an increase in a cell-membrane area, an increase in formation and secretion of an outer membrane vesicle, and an increase in formation of an inner membrane vesicle, and a cell-membrane engineering method for preparation thereof, whereby an insoluble hydrophobic material can be produced with high efficiency, the recombinant microorganism for high-efficiency production of carotenoids or violacein analogues is useful for producing natural pigments, antioxidants, antibiotics, cosmetic additives, anticancer agents, food additives, or nutritional supplements, and the natural pigment production technology developed herein achieves a great increase in production ability.
    Type: Application
    Filed: November 1, 2021
    Publication date: May 5, 2022
    Inventors: Sang Yup LEE, Dongsoo Yang, Seon Young Park
  • Publication number: 20220040261
    Abstract: The present invention relates to a composition for treating hair loss or promoting hair growth which contains a silk protein, and plasma or serum components. According to the present invention, due to the synergistic effect of a silk protein and plasma or serum components, the effect of promoting hair growth and the effect of treating hair loss can be expected to be more efficient.
    Type: Application
    Filed: November 21, 2019
    Publication date: February 10, 2022
    Inventors: Sang Yup LEE, Won Min YOO, Sooncheol KIM, Hannah CHUNG, Deok Hyun NA
  • Publication number: 20220017879
    Abstract: Disclosed is a recombinant microorganism capable of growing using only carbon dioxide and formic acid by introducing and improving a metabolic pathway for synthesizing pyruvic acid from carbon dioxide and formic acid to enhance pyruvic acid synthesis efficiency and performing additional genetic manipulation, and a method for producing useful substances using the same. Advantageously, the recombinant microorganism is capable of synthesizing pyruvic acid, a C3 organic compound, at a remarkably improved rate, and in particular, grows well even in a medium containing only carbon dioxide and formic acid as carbon sources without a glucose supply, and is thereby capable of synthesizing pyruvic acid and various high value-added compounds using the same as an intermediate product in an economically efficient manner.
    Type: Application
    Filed: July 2, 2021
    Publication date: January 20, 2022
    Inventors: Sang Yup LEE, Junho BANG, Chang Hun HWANG, Jung Ho AHN, Jong An LEE
  • Publication number: 20220008463
    Abstract: The present invention relates to a pharmaceutical composition for treating wounds, containing a silk protein and a plasma component as active ingredients. According to the present invention, wounds can be more effectively healed by using synergistic effects of a silk protein and a plasma component.
    Type: Application
    Filed: November 21, 2019
    Publication date: January 13, 2022
    Inventors: Sang Yup LEE, Won Min YOO, Sooncheol KIM, Hannah CHUNG, Jiyong KIM
  • Patent number: 11216115
    Abstract: According to an embodiment, a method for operating an electronic device may comprise operating touch circuitry configured to detect a touch or hovering according to a first driving signal in a first operation mode, detecting a first event related to mode switching, and operating the touch circuitry according to a second driving signal different from the first driving signal in a second operation mode based on detecting the first event. Other embodiments are also possible.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: January 4, 2022
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Sang-Yup Lee, Tae-Kyoung Kang, Yeon-Hwan Kim, Jun-Ho Ko, Young-Jun An, Won-Woo Yoo, Ji-Young Lim, Jang-Hoon Hong, Hyun-Suk Choi
  • Patent number: 11214816
    Abstract: The present invention relates to a recombinant microorganism having heterologous genes introduced thereto and a method for producing a useful material from formic acid and carbon dioxide using the microorganism. The present invention provides a novel microorganism having a cyclic metabolic pathway introduced thereto through which C3 or higher carbon organic compounds can be synthesized from formic acid and carbon dioxide, whereby carbon dioxide rich in nature and formic acid that is of low toxicity and suitable for anabolic reaction in view of reaction kinetics and which can be easily and rapidly synthesized from carbon dioxide can be used to effectively synthesize the C3 organic compound pyruvic acid from which various high-value added compound can be synthesized.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: January 4, 2022
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Yup Lee, Junho Bang
  • Publication number: 20210375400
    Abstract: The present invention relates to a method for predicting a drug-drug interaction and a drug-food interaction by using structural information of a drug and, more particularly, to a method for predicting the mechanism of action and activity of a drug interaction through interaction prediction results expressed by a standardized sentence. When using a method for predicting a drug interaction according to the present invention, a drug interaction can be predicted quickly and accurately, and in particular, activity information of an unknown compound can also be predicted by expressing a prediction result by means of a sentence, and thus the method is very useful for developing a drug exhibiting desired activity without causing adverse effects.
    Type: Application
    Filed: November 20, 2018
    Publication date: December 2, 2021
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Yup LEE, Jae Yong RYU, Hyun Uk KIM
  • Publication number: 20210332332
    Abstract: Disclosed are a mutant microorganism for producing succinic acid exhibiting improved activity of conversion of oxaloacetate to malate through the introduction of genes encoding a malate dehydrogenase, wherein an amino acid residue that interacts with a pyrophosphate moiety of NADH through an amide functional group of a main chain of malate dehydrogenase is glutamine (Gln), and a method of producing succinic acid using the same. The mutant microorganism producing succinic acid according to the present invention is capable of producing a high concentration of succinic acid at the highest productivity compared to other mutant microorganisms reported to date when the microorganism is cultured in a limited medium. In addition, the mutant microorganism is capable of producing succinic acid at higher productivity and product concentration through further advanced fermentation technology.
    Type: Application
    Filed: May 2, 2019
    Publication date: October 28, 2021
    Inventors: Sang Yup LEE, Kyung-Jin KIM, Jung Ho AHN, Hogyun SEO, Jong An LEE
  • Publication number: 20210317486
    Abstract: Disclosed is a method of preparing primary amines. More particularly, disclosed are a mutant microorganism transformed with a gene encoding a valine decarboxylase and a method of preparing primary amines from amino acids using the mutant microorganism. The method has an effect of synthesizing, in an environmentally friendly manner, primary amines as precursors for pharmaceuticals and agricultural chemicals using microorganisms, as an alternative to conventional chemical synthesis methods.
    Type: Application
    Filed: March 6, 2021
    Publication date: October 14, 2021
    Inventors: Sang Yup LEE, Dong In KIM, Tong Un CHAE
  • Publication number: 20210277428
    Abstract: The present invention relates to a recombinant microorganism for malonyl-CoA detection in which a type III polyketide synthase-encoding gene is inserted in the genome or in which a recombinant vector containing the gene is introduced; a method of screening a malonyl-CoA production-inducing substance using the recombinant microorganism; a method of screening a gene which is involved in increased malonyl-CoA production; and a method comprising knocking down the gene, screened by the method, in a microorganism, thus increasing the production of malonyl-CoA in the microorganism, and producing a useful substance in the microorganism using malonyl-CoA as a precursor. The use of the biosensor according to the present invention provides single-step signal generation, utilization in various microorganisms, utilization in self-fluorescent microorganisms, a simple construction method, and a simple screening method.
    Type: Application
    Filed: August 30, 2018
    Publication date: September 9, 2021
    Inventors: Sang Yup Lee, Dongsoo YANG
  • Patent number: 11097202
    Abstract: The present invention relates to a process for energy recovery in a process for the preparation of 1,3,5-trioxane.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: August 24, 2021
    Assignees: BASF SE, Kolon Plastics Inc.
    Inventors: Achim Stammer, Thomas Heitz, Marvin Kramp, JongMoon Kim, In-Gi Cho, Jin-Sang Choi, Sang-Yup Lee
  • Publication number: 20210217063
    Abstract: The present invention relates to a marketing system that supports sales of goods by interlocking a customer terminal and an administrator terminal, which comprises: a central server (100) which provides an event page production tool to the administrator terminal, receives information about an event page, and transmits the received event page to the customer terminal; an administrator terminal (200) for receiving the event page production tool from the central server to input corresponding variables to produce an event page; and a customer terminal for receiving the event page produced by the administrator terminal from the central server and inputting necessary information while performing a process provided by the event page.
    Type: Application
    Filed: April 25, 2019
    Publication date: July 15, 2021
    Inventor: Sang Yup LEE
  • Publication number: 20210214753
    Abstract: The present invention relates to recombinant Corynebacterium having 1,3-PDO productivity and reduced 3-HP productivity, and a method for producing 1,3-PDO by using same. When a Corynebacterium glutamicum variant according to the present invention is used, the productivity of 3-HP, which is a by-product, is inhibited by using low-cost glycerol as a carbon source, and thus 1,3-PDO can be produced with high efficiency.
    Type: Application
    Filed: April 24, 2019
    Publication date: July 15, 2021
    Applicants: Korea Advanced Institute of Science and Technology, Hanwha Solutions Corporation
    Inventors: Sang Yup LEE, Jae Sung CHO, Je Woong KIM, Cindy Pricilia Surya PRABOWO, Taehee HAN, Yoo Sung KO
  • Patent number: 11041105
    Abstract: The present invention provides a composition comprising branched polyglycerol for controlling freezing, more specifically, the composition has a number average molecular weight of 1,000 to 20,000 g/mol and a branching of 0.1 to 1, and may control enhancement or inhibition of ice recrystallization by adjusting a content of polyglycerol.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: June 22, 2021
    Assignees: KOREA UNIVERSITY RESEARCH AND, BUSINESS FOUNDATION, Please check the appropriate assignee category or categories (will not be printed on the pate, INDUSTRY-ACADEMIC COOPERATION, FOUNDATION, YONSEI UNIVERSITY
    Inventors: Dong June Ahn, Byeong Su Kim, Sang Yup Lee, Woo Hyuk Jung, Min Seong Kim, Young Joo Hong
  • Publication number: 20210163805
    Abstract: The present invention provides a composition comprising branched polyglycerol for controlling freezing, more specifically, the composition has a number average molecular weight of 1,000 to 20,000 g/mol and a branching of 0.1 to 1, and may control enhancement or inhibition of ice recrystallization by adjusting a content of polyglycerol.
    Type: Application
    Filed: December 3, 2019
    Publication date: June 3, 2021
    Applicants: Korea University Research and Business Foundation, INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    Inventors: Dong June AHN, Byeong Su KIM, Sang Yup LEE, Woo Hyuk JUNG, Min Seong KIM, Young Joo HONG
  • Publication number: 20210155495
    Abstract: The present invention provides a composition for antifreezing including a gold (Au) nanostructure in which at least a portion thereof is concave, thereby it is possible to increase a survival rate of cells due to having excellent effect of inhibiting ice recrystallization when cryopreservation of the cells, and maintain a texture of food even when using in the freezing of food.
    Type: Application
    Filed: December 3, 2019
    Publication date: May 27, 2021
    Applicant: Korea University Research and Business Foundation
    Inventors: Dong June AHN, Sang Yup Lee, Yong Ho Cho
  • Patent number: D917347
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: April 27, 2021
    Assignees: Hyundai Motor Company, Kia Motors Corporation
    Inventors: Sang Yup Lee, Soo Yul Bae, Samir Sadikhov, Donckerwolke Luc, Sergej Bruhler, Arseny Kostromin