Abstract: The present invention explored PLGA NPs synthesis using plant extracts as surfactants by nanoprecipitation process. PLGA NPs synthesized using Camellia sinensis, Dendrocalamus hamiltonii, Ficus palmata and Rubus ellipticus leaf extracts were further explored for encapsulation, controlled and sustained release of well-known antioxidant molecule, curcumin. This plant extract based nanoprecipitation process for the synthesis of PLGA NPs can be further explored for encapsulation of many other antioxidant molecules of therapeutic importance.

Abstract: System and techniques for distributed telemetry platform are described herein. A telemetry pipeline comprising ordered executable blocks is obtained. Each of these executable blocks including a requirements data structure. A first executable block of the telemetry pipeline is sent to a first agent based on first requirements in the requirements data structure for that executable block. A second executable block of the telemetry pipeline to a second agent based on second requirements in the requirements data structure for the second executable block. The telemetry pipeline is then executed to obtain an indication that the first agent does not meet the first requirements after execution of the telemetry pipeline has begun. In response, the first executable block is moved from the first agent to a third agent.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that manage cryptographically secure exchanges of data using a permissioned distributed ledger. For example, an apparatus obtains parameter values characterizing an exchange of data and transmits the parameter values to a first computing system, which executed instructions included within a distributed ledger. The executed additional instructions cause the first computing system to access rules data recorded onto the distributed ledger and establish a consistency between the parameter values and at least a portion of the accessed rules data. The apparatus receives, from the first computing system, confirmation data indicative of the established consistency, and based on the confirmation data, transmit a request to execute the data exchange in accordance with at least the portion of the parameter values to a second computing system.

Abstract: A key-value pair comprising a key and a value associated with the key is stored in a current segment of a data container. The key comprises a segment identifier identifying the current segment. The data container comprises a plurality of segments residing on a non-volatile memory device. Responsive to determining that a size of the current segment exceeds a threshold, a new segment is added to the container. The plurality of key-value pairs having respective current segment identifiers referencing one or more least recently created segments of the data container is deleted.

Abstract: A method for creating an interpretable model for healthcare predictions includes training, by a deep learning processor, a neural network to predict health information by providing training data, including multiple combinations of measured or observed health metrics and corresponding medical results, to the neural network. The method also includes determining, by the deep learning processor and using the neural network, prediction data including predicted results for the measured or observed health metrics for each of the multiple combinations of the measured or observed health metrics based on the training data. The method also includes training, by the deep learning processor or a learning processor, an interpretable machine learning model to make similar predictions as the neural network by providing mimic data, including combinations of the measured or observed health metrics and corresponding predicted results of the prediction data, to the interpretable machine learning model.

Abstract: A device may receive a request to initiate an audio test and may generate, based on the request, one or more instructions to control a bone transducer device and a microphone device. The device may send the one or more instructions to a control device and may receive, after sending the one or more instructions, audio data from the control device. The device may process the audio data to determine whether the audio data includes an otoacoustic emission (OAE) and may cause at least one action to be performed based on determining whether the OAE is included in the audio data.

Abstract: A sensor comprising a light emitter and light detector directly covered and encapsulated by a layer of light transmissive compound. A gap in the light transmissive compound between the light emitter and the light detector filled with an infrared ink. In some embodiments, an infrared ink can cover at least a portion of a top surface of the sensor and define apertures above the light detector and/or light emitter.

Abstract: A method for deleting obsolete files from a file system is provided. The method includes receiving a request to delete a reference to a first target file of a plurality of target files stored in a file system, the first target file having a first target file name. A first reference file whose file name includes the first target file name is identified. The first reference file is deleted from the file system. The method further includes determining whether the file system includes at least one reference file, distinct from the first reference file, whose file name includes the first target file name. In accordance with a determination that the file system does not include the at least one reference file, the first target file is deleted from the file system.

Abstract: Low-latency autonomous-analysis includes obtaining data expressing a usage intent with respect to a low-latency database analysis system that intent omits data corresponding to user input expressly requesting low-latency autonomous-analysis, obtaining requested results data based on the data expressing the usage intent, outputting requested visualization data representing at least a portion of the requested results data for presentation to a user, and, in response to outputting the requested visualization data, obtaining low-latency autonomous-analysis data by performing low-latency autonomous-analysis based on the data expressing the usage intent by identifying an autonomous-analysis predicate based on the requested visualization data, obtaining a defined autonomous-analysis latency constraint, obtaining the low-latency autonomous-analysis data based on the autonomous-analysis predicate in accordance with the defined autonomous-analysis latency constraint, such that the low-latency autonomous-analysis data d

Abstract: The present disclosure provides novel methods for increasing ?-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition. Kits and compositions including RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, are also provided to increase ?-cell viability.

Abstract: Solid state forms of Ivosidenib, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.

Abstract: A computer-implemented method for the automatic generation of photorealistic 3D avatars. The method includes generating, using machine learning network, a plurality of 2D photorealistic facial images; generating, using a model agnostic meta-learner, a plurality of 2D photorealistic facial expression images based on the plurality of 2D photorealistic facial images; and generating a plurality of 3D photorealistic avatars based on the plurality of 2D photorealistic facial expression images.

Abstract: Described herein are methods and apparatuses for filling semiconductor substrate structures with conductive material. The methods involve depositing multi-layer bulk metal films in structures with one or more deposition conditions changed when transitioning from layer-to-layer. The methods result in high fill quality, high throughput, low precursor consumption, and low roughness. Multi-station chambers to perform the methods are also provided.

Abstract: Techniques for network routing border convergence are described. Backup paths for external connections for a network are established and provide for a temporary path for network traffic during network routing convergence, preventing traffic loss at network border nodes.

Abstract: A method, apparatus and computer program product are provided for extracting building footprints for buildings based on satellite imagery. In this regard, a segmentation map is generated by performing an image segmentation on satellite imagery depicting at least one building. A plurality of line segments that correspond to edges of the at least one building are also generated. Furthermore, a contour for each of the at least one building is generated by filtering line segments corresponding to the at least one building based on the respective principle direction. The geographic data for each of the at least one building is then extracted based on the respective contour.

Abstract: A transmitter includes a data stream encoder layer having an output and a pattern generator having a bit pattern output. The transmitter further includes a first multiplexer having first and second inputs and a first multiplexer output. The first input is coupled to the output of the data stream encoder layer, and the second input is coupled to the bit pattern output of the pattern generator. While at least a portion of the data stream encoder layer is powered down, the pattern generator is configured to provide bit patterns on its bit pattern output, a control signal to the first multiplexer is configured to select the second input of the first multiplexer, and the first multiplexer is configured to output the bit patterns on the output of the first multiplexer.

Abstract: Disclosed are systems and methods for personalized care management. The method includes collecting login credentials of a user. The login credentials are checked and the user is authenticated accordingly. Then, user profile of the user is accessed to determine a specific role of the user. Based on the specific role of the user, a user interface is presented on a user device of the user. The user interacts with the user interface by providing at least one voice input including a request. Further, a notification is generated based on the voice input of the user for at least one user. The at least one user provides at least one voice input including a response for the user via a user interface on at least one user device of the at least one user. The response is presented to the user through the user interface.

Abstract: A computer-implemented method for the automatic generation of photorealistic 3D avatars. The method includes generating, using machine learning network, a plurality of 2D photorealistic facial images; generating, using a model agnostic meta-learner, a plurality of 2D photorealistic facial expression images based on the plurality of 2D photorealistic facial images; and generating a plurality of 3D photorealistic avatars based on the plurality of 2D photorealistic facial expression images.

Abstract: Improving a security configuration may include receiving a request to assign a single sign-on configuration for a user profile, present a user interface comprising input fields for configuration characteristics, receiving an indication from the user interface that an administrator is requesting the assign the configuration characteristics, in response to receiving the indication, performing a test connection using the configuration profile, and in response to determining that the test connection succeeded, prompting the administrator to activate the single sign-on communication for the user profile.

Abstract: Described is a system, method, and computer program product to perform monitoring for process-based OS resource utilization by individual database instances in a multi-database environment. This approach may be used to resolve numerous resource allocation and monitoring problems, such as the noisy neighbor problem.