Patents by Inventor Santiago Ini

Santiago Ini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal forms of 9-hydroxy-risperidone (paliperidone)
    Publication number: 20080177067
    Abstract: The present invention provides amorphous and crystalline forms of Paliperidone, and processes for preparing thereof.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 24, 2008
    Inventors: Ben-Zion Dolitzky, Santiago Ini, Naama Chasid, Yaron Shmuely, Kobi Chen, Eli Lancry
  • Polymorphic forms of rosiglitazone hydrobromide and processes for preparation thereof
    Publication number: 20080176905
    Abstract: The present invention presents crystal forms of Rosiglitazone hydrobromide, denominated Form I and Form II, methods of their preparation, as well as pharmaceutical compositions comprising these crystalline forms.
    Type: Application
    Filed: January 22, 2008
    Publication date: July 24, 2008
    Inventors: Santiago Ini, Kobi Chen, Michal Rafilovich
  • Pure paliperidone and processes for preparing thereof
    Publication number: 20080171876
    Abstract: The present invention provides pure paliperidone as well as purification processes to obtain thereof.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 17, 2008
    Inventors: Santiago Ini, Naama Chasid, Kobi Chen, Osnat Porter-Kleks
  • Process for the synthesis of 9-hydroxy risperidone (paliperidone)
    Publication number: 20080171875
    Abstract: The present invention relates to a process for preparing paliperidone from its intermediate 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 17, 2008
    Inventors: Santiago Ini, Naama Chasid, Yaron Shmuely, Kobi Chen
  • Crystal forms of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate and the preparation thereof
    Patent number: 7399871
    Abstract: DNT-Oxal crystalline forms and processes for making DNT-Oxal crystalline forms are provided.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: July 15, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Santiago Ini, Anita Liberman, Tamas Koltai
  • Carvedilol phosphate
    Publication number: 20080125476
    Abstract: The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical compositions comprising the novel amorphous and crystalline forms and uses thereof.
    Type: Application
    Filed: June 28, 2007
    Publication date: May 29, 2008
    Inventors: Santiago Ini, Sigalit Levi, Michal Rafilovich, Judith Aronhime, Mili Abramov, Ron Bar-Shavit, Eran Turgeman
  • Duloxetine HCL polymorphs
    Publication number: 20080027128
    Abstract: A crystalline form of duloxetine hydrochloride, pharmaceutical compositions of the crystalline form of duloxetine hydrochloride, and methods of preparing the crystalline form of duloxetine hydrochloride are provided.
    Type: Application
    Filed: May 23, 2007
    Publication date: January 31, 2008
    Inventors: Santiago Ini, Tamas Koltai, Shalom Shabat
  • Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate
    Publication number: 20080015363
    Abstract: A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided.
    Type: Application
    Filed: February 21, 2007
    Publication date: January 17, 2008
    Inventors: Santiago Ini, Yaron Shmuely, Mili Abramov
  • Process for the preparation of optically active (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
    Publication number: 20080015362
    Abstract: Duloxetine intermediates, processes for their preparation, and their conversion to pharmaceutically acceptable salts of duloxetine are described.
    Type: Application
    Filed: April 17, 2007
    Publication date: January 17, 2008
    Inventors: Santiago Ini, Yaron Shmuely
  • Process for preparing duloxetine and intermediates thereof
    Publication number: 20070281989
    Abstract: Processes for preparing chemically pure duloxetine and chemically pure duloxetine intermediates are provided.
    Type: Application
    Filed: May 31, 2007
    Publication date: December 6, 2007
    Inventors: Santiago Ini, Mili Abramov
  • Process for the preparation of(s)-(+)-N,N-dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)propanamine, A duloxetine intermediate
    Publication number: 20070238883
    Abstract: Provided is a process for preparing a duloxetine intermediate, (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine (DNT), and its conversion to duloxetine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 11, 2007
    Inventors: Santiago Ini, Yaron Shmuely, Mili Abramov
  • Process for preparing a crystalline form of Tegaserod maleate
    Publication number: 20070225507
    Abstract: Provided is a process for preparing tegaserod maleate.
    Type: Application
    Filed: January 18, 2007
    Publication date: September 27, 2007
    Inventors: Gustavo Frenkel, Santiago Ini
  • Maleate salt of tegaserod and crystalline forms thereof
    Publication number: 20070208072
    Abstract: Provided is sesqui-tegaserod maleate and processes for preparation thereof.
    Type: Application
    Filed: January 18, 2007
    Publication date: September 6, 2007
    Inventors: Gustavo Frenkel, Santiago Ini, Tamas Koltai
  • DNT-fumarate and methods of preparation thereof
    Publication number: 20070191471
    Abstract: (S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine fumarate (DNT-fumarate) and polymorphs of DNT-fumarate, compositions of DNT-fumarate and its polymorphs, processes for the preparation of DNT-fumarate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-fumarate are provided.
    Type: Application
    Filed: September 21, 2006
    Publication date: August 16, 2007
    Inventors: Santiago Ini, Anita Liberman, Mili Abramov, Tamas Koltai
  • 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride
    Publication number: 20070191472
    Abstract: The invention encompasses 2-N-methyl-propanamine)-3-(2-naphthol) thiophene, a duloxetine hydrochloride impurity, as well as its use as a reference marker and reference standard.
    Type: Application
    Filed: December 5, 2006
    Publication date: August 16, 2007
    Inventors: Santiago Ini, Alexei Ploutno, Anita Liberman, Mili Abramov, Osnat Porter-Kleks, Dina Berezovsky
  • DNT-maleate and methods of preparation thereof
    Publication number: 20070185192
    Abstract: (S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine maleate (DNT-maleate) and polymorphs of DNT-maleate, compositions of DNT-maleate and its polymorphs, processes for the preparation of DNT-maleate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-maleate are provided.
    Type: Application
    Filed: September 21, 2006
    Publication date: August 9, 2007
    Inventors: Santiago Ini, Anita Liberman, Mili Abramov, Tamas Koltai
  • DNT-benzenesulfonate and methods of preparation thereof
    Publication number: 20070173540
    Abstract: (S)—N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine benzenesulfonate (DNT-benzenesulfonate) and polymorphs of DNT-benzenesulfonate, compositions of DNT-benzenesulfonate and its polymorphs, processes for the preparation of DNT-benzenesulfonate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-benzenesulfonate are provided.
    Type: Application
    Filed: September 21, 2006
    Publication date: July 26, 2007
    Inventors: Santiago Ini, Mili Abramov, Tamas Koltai
  • DNT-succinate and methods of preparation thereof
    Publication number: 20070173541
    Abstract: (S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine succinate (DNT-succinate) and polymorphs of DNT-succinate, compositions of DNT-succinate and its polymorphs, processes for the preparation of DNT-succinate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-succinate are provided.
    Type: Application
    Filed: September 21, 2006
    Publication date: July 26, 2007
    Inventors: Santiago Ini, Mili Abramov, Tamas Koltai
  • Polymorphic forms of tegaserod maleate
    Publication number: 20070112057
    Abstract: Provided are crystalline forms of tegaserod maleate and processes for the preparation thereof.
    Type: Application
    Filed: June 22, 2006
    Publication date: May 17, 2007
    Inventors: Santiago Ini, Tamas Koltai, Michael Pinchasov, Sofia Gorohovsky, Gustavo Frenkel
  • Process for the purification of duloxetine hydrochloride
    Publication number: 20060276660
    Abstract: Process for the purification of duloxetine HCl is provided.
    Type: Application
    Filed: March 14, 2006
    Publication date: December 7, 2006
    Inventors: Santiago Ini, Mili Abramov, Anita Liberman