Abstract: Systems and methods for executing queries on a bitmap index are disclosed. The system may receive a first data stream from a database and generate a bitmap index based on the first data stream. The system may receive an input selection of one or more data conditions from a user device and generate a Boolean expression based on the input selection. The system may query the bitmap index using the Boolean expression and generate a bitmap vector. The system may output a first data subset represented by the generated bitmap vector to a graphical user interface. The bitmap index may include probabilistic entries, and the system may validate the probabilistic entries by receiving a second data stream, identifying one or more entries correlated to the probabilistic entries, determining a divergence between the identified entries and the probabilistic entries, and updating parameters of a classifier model associated with the probabilistic entries.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: Systems and methods for automatically determining target populations for statistical experiments are disclosed. The system may receive a hypothesis associated with a statistical experiment and a target population, the hypothesis including one or more target metrics. The system may receive one or more target parameters associated with the target population. The system may determine whether the one or more target parameters match a stored query. In response to the target parameters matching the stored query, the system may query, using the stored query, a user database to determine the target population satisfying the target parameters. The system may predict a sample size for the statistical experiment based on the target population and the target metrics and transmit to the user device a graphical user interface including the predicted sample size.

Abstract: The present disclosure provides embodiments that include storing an alert database defining a plurality of alert events for a vehicle where the plurality of alert events indicating deviations from a desired operation of the vehicle, detecting an alert event of one of the plurality of alert events by monitoring an output of a sensor in the vehicle, searching the alert database to identify a crew response for the alert event, identifying a current operational phase of the vehicle, contextualizing, based on the current operational phase, the alert event to assign an alert level to the alert event, and outputting, for display, the alert event.

Abstract: The present disclosure provides detecting an alert event in a vehicle by monitoring an output of a sensor in the vehicle, identifying a first operational phase of the vehicle that is operationally impacted by the alert event, identifying a current operational phase of the vehicle, and in response to determining that the first operational phase is a future operational phase relative to the current operational phase of the vehicle, assigning a lower alert level to the alert event, and outputting, for display in a graphical user interface (GUI), the alert event with the lower alert level.

Abstract: The present disclosure describes identifying a normal mission of a vehicle based on descriptions of capabilities of the vehicle in a plurality of operational phases where the normal mission is divided into the plurality of operational phases, identifying violations of the descriptions of the capabilities that cause the vehicle to deviate from the normal mission in at least one of the plurality of operational phases, identifying operational impacts on the vehicle caused by the violations, assigning alert levels to the operational impacts, populating an alert database that stores alert events corresponding to the violations and the alert levels assigned to the operational impacts; and generating software code to monitor sensor data during operation of the vehicle to identify the violations.

Abstract: The present application relates generally to cancer treatment strategies using arenavirus particles. The treatment strategies described herein are for treating cancer, including head and neck squamous cell carcinoma, using tri-segmented arenavirus particles encoding a human papillomavirus (HPV) antigen. The treatment strategies described herein can include administration of an immune checkpoint inhibitor.

Abstract: The instant disclosure generally relates to a composition for treating or coloring keratin fibers, the composition comprising at least one bio-based polymer and optionally a crosslinker. The composition may also comprise pigment microparticles. The composition formed and set in situ as a solid linked coating has a substantially permanent pigment lastingness and minimally alters the keratin fibers.

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

Abstract: Provided herein are genetically modified arenaviruses suitable as vaccines against neoplastic diseases or cancer. The invention also relates to pharmaceutical compositions and methods for the prevention or treatment of certain infections causing neoplastic diseases or cancer, such as infections with oncogenic viruses. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing or treating diseases and conditions caused by and associated with infections with Human Papillomavirus (HPV), such as cervical cancer, anogenital cancer, head and neck cancer and skin cancers. Also provided herein are immunotherapies for the treatment of a neoplastic disease, such as a neoplastic disease caused by infection with oncogenic viruses.

Abstract: The present disclosure relates to methods, treatment regimens, uses, kits, compositions and medicaments for treating an inflammatory or obstructive airway disease, such as asthma, including severe asthma, or COPD, by employing an anti-TSLP antibody or anti-TSLP antibody fragment.

Abstract: A method for increasing fail-safe operation of an industrial input/output assembly, wherein an external mechanical load that acts on the input/output assembly is determined via an acceleration sensor, where a check is performed to determine whether the load exceeds a predeterminable limit value and, if this is the case, a value of a load sum is then accordingly increased corresponding to an extent to which the value is exceeded, where the load sum is continuously compared to a maximum load value that characterizes a service life of the input/output assembly, and a maintenance message is output when the maximum load value is reached.

Abstract: Systems and methods for executing queries on a bitmap index are disclosed. The system may receive a first data stream from a database and generate a bitmap index based on the first data stream. The system may receive an input selection of one or more data conditions from a user device and generate a Boolean expression based on the input selection. The system may query the bitmap index using the Boolean expression and generate a bitmap vector. The system may output a first data subset represented by the generated bitmap vector to a graphical user interface. The bitmap index may include probabilistic entries, and the system may validate the probabilistic entries by receiving a second data stream, identifying one or more entries correlated to the probabilistic entries, determining a divergence between the identified entries and the probabilistic entries, and updating parameters of a classifier model associated with the probabilistic entries.

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

Abstract: The present application relates generally to genetically modified arenaviruses that are suitable vaccines against neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable for vaccines and/or treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus in combination with an immune checkpoint inhibitor, wherein the arenavirus has been engineered to include a nucleotide sequence encoding a tumor antigen, tumor associated antigen or antigenic fragment thereof.

Abstract: Provided herein are genetically modified arenaviruses suitable as vaccines against neoplastic diseases or cancer. The invention also relates to pharmaceutical compositions and methods for the prevention or treatment of certain infections causing neoplastic diseases or cancer, such as infections with oncogenic viruses. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing or treating diseases and conditions caused by and associated with infections with Human Papillomavirus (HPV), such as cervical cancer, anogenital cancer, head and neck cancer and skin cancers. Also provided herein are immunotherapies for the treatment of a neoplastic disease, such as a neoplastic disease caused by infection with oncogenic viruses.

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.