Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

Abstract: Systems and methods for executing queries on a bitmap index are disclosed. The system may receive a first data stream from a database and generate a bitmap index based on the first data stream. The system may receive an input selection of one or more data conditions from a user device and generate a Boolean expression based on the input selection. The system may query the bitmap index using the Boolean expression and generate a bitmap vector. The system may output a first data subset represented by the generated bitmap vector to a graphical user interface. The bitmap index may include probabilistic entries, and the system may validate the probabilistic entries by receiving a second data stream, identifying one or more entries correlated to the probabilistic entries, determining a divergence between the identified entries and the probabilistic entries, and updating parameters of a classifier model associated with the probabilistic entries.

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

Abstract: The invention relates to genetically modified arenaviruses suitable for the treatment of neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable for treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus, wherein the arenavirus has been engineered to include a nucleotide sequence encoding one or more antigenic fragment(s) of mutant KRAS alone or to further include a nucleotide sequence encoding one or more antigenic fragment(s) of a mutated cancer driver gene (e.g., a mutant TP53) or a tumor-associated antigen.

Abstract: Provided herein are methods and compositions for the treatment of neoplastic and infectious diseases. Specifically, provided herein are combination treatments that combine arenavirus-vectored antigens, such as tumor antigens or antigens of pathogens, with various immune checkpoint modulators or cytokines, which may in turn themselves be expressed using the arenavirus-based expression system.

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

Abstract: The present application relates generally to genetically modified arenaviruses that are suitable vaccines against neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable as vaccines and/or for treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus in combination with a chemotherapeutic agent, wherein the arenavirus has been engineered to include a nucleotide sequence encoding a tumor antigen, tumor associated antigen or antigenic fragment thereof.

Abstract: The present disclosure describes identifying a normal mission of a vehicle based on descriptions of capabilities of the vehicle in a plurality of operational phases where the normal mission is divided into the plurality of operational phases, identifying violations of the descriptions of the capabilities that cause the vehicle to deviate from the normal mission in at least one of the plurality of operational phases, identifying operational impacts on the vehicle caused by the violations, assigning alert levels to the operational impacts, populating an alert database that stores alert events corresponding to the violations and the alert levels assigned to the operational impacts; and generating software code to monitor sensor data during operation of the vehicle to identify the violations.

Abstract: The present disclosure provides embodiments that include storing an alert database defining a plurality of alert events for a vehicle where the plurality of alert events indicating deviations from a desired operation of the vehicle, detecting an alert event of one of the plurality of alert events by monitoring an output of a sensor in the vehicle, searching the alert database to identify a crew response for the alert event, identifying a current operational phase of the vehicle, contextualizing, based on the current operational phase, the alert event to assign an alert level to the alert event, and outputting, for display, the alert event.

Abstract: The present application relates to arenavirus particles containing a genome engineered such that an arenaviral open reading frame (“ORF”) is sequestered into two or more functional fragments and these fragments are expressed from two or more viral mRNA transcripts. The arenavirus particles described herein are genetically stable and provide high-level transgene expression. In certain embodiments, the arenavirus particles are tri-segmented. In particular, described herein is a nucleotide sequence comprising one or more ORFs comprising a nucleotide sequence encoding a functional fragment of arenavirus GP, NP, L or Z. Also described herein is an arenavirus particle containing a genome engineered such that an arenaviral ORF is sequestered into two or more functional fragments and these fragments are expressed from two or more viral mRNA transcripts.

Abstract: Systems and methods for executing queries on a bitmap index are disclosed. The system may receive a first data stream from a database and generate a bitmap index based on the first data stream. The system may receive an input selection of one or more data conditions from a user device and generate a Boolean expression based on the input selection. The system may query the bitmap index using the Boolean expression and generate a bitmap vector. The system may output a first data subset represented by the generated bitmap vector to a graphical user interface. The bitmap index may include probabilistic entries, and the system may validate the probabilistic entries by receiving a second data stream, identifying one or more entries correlated to the probabilistic entries, determining a divergence between the identified entries and the probabilistic entries, and updating parameters of a classifier model associated with the probabilistic entries.

Abstract: The present disclosure provides embodiments that include storing an alert database defining a plurality of alert events for a vehicle where the plurality of alert events indicating deviations from a desired operation of the vehicle, detecting an alert event of one of the plurality of alert events by monitoring an output of a sensor in the vehicle, searching the alert database to identify a crew response for the alert event, identifying a current operational phase of the vehicle, contextualizing, based on the current operational phase, the alert event to assign an alert level to the alert event, and outputting, for display, the alert event.

Abstract: The present application relates to arenaviruses expressing prostate cancer-related antigens. In particular, described herein is a modified arenavirus particle which is engineered to carry a heterologous open reading frame (ORF) encoding a prostate cancer-related antigen or an antigenic fragment thereof, wherein the prostate cancer-related antigen is selected from the group consisting of: prostatic acid phosphatase (PAP), prostate specific antigen (PSA), and prostate-specific membrane antigen (PSMA). Also described herein are arenavius genome segments or S segments encoding the prostate cancer-related antigen or an antigenic fragment thereof, cDNA, DNA expression vector, a pharmaceutical composition comprising such an arenavirus particle, methods of generating such an arenavirus particle and treating prostate cancer using such an arenavirus particle, and a kit for such usage.

Abstract: Systems and methods for executing queries on a bitmap index are disclosed. The system may receive a first data stream from a database and generate a bitmap index based on the first data stream. The system may receive an input selection of one or more data conditions from a user device and generate a Boolean expression based on the input selection. The system may query the bitmap index using the Boolean expression and generate a bitmap vector. The system may output a first data subset represented by the generated bitmap vector to a graphical user interface. The bitmap index may include probabilistic entries, and the system may validate the probabilistic entries by receiving a second data stream, identifying one or more entries correlated to the probabilistic entries, determining a divergence between the identified entries and the probabilistic entries, and updating parameters of a classifier model associated with the probabilistic entries.

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: Systems and methods for automatically determining target populations for statistical experiments are disclosed. The system may receive a hypothesis associated with a statistical experiment and a target population, the hypothesis including one or more target metrics. The system may receive one or more target parameters associated with the target population. The system may determine whether the one or more target parameters match a stored query. In response to the target parameters matching the stored query, the system may query, using the stored query, a user database to determine the target population satisfying the target parameters. The system may predict a sample size for the statistical experiment based on the target population and the target metrics and transmit to the user device a graphical user interface including the predicted sample size.

Abstract: The present disclosure describes identifying a normal mission of a vehicle based on descriptions of capabilities of the vehicle in a plurality of operational phases where the normal mission is divided into the plurality of operational phases, identifying violations of the descriptions of the capabilities that cause the vehicle to deviate from the normal mission in at least one of the plurality of operational phases, identifying operational impacts on the vehicle caused by the violations, assigning alert levels to the operational impacts, populating an alert database that stores alert events corresponding to the violations and the alert levels assigned to the operational impacts; and generating software code to monitor sensor data during operation of the vehicle to identify the violations.

Abstract: The present disclosure provides detecting an alert event in a vehicle by monitoring an output of a sensor in the vehicle, identifying a first operational phase of the vehicle that is operationally impacted by the alert event, identifying a current operational phase of the vehicle, and in response to determining that the first operational phase is a future operational phase relative to the current operational phase of the vehicle, assigning a lower alert level to the alert event, and outputting, for display in a graphical user interface (GUI), the alert event with the lower alert level.

Abstract: The present disclosure provides embodiments that include storing an alert database defining a plurality of alert events for a vehicle where the plurality of alert events indicating deviations from a desired operation of the vehicle, detecting an alert event of one of the plurality of alert events by monitoring an output of a sensor in the vehicle, searching the alert database to identify a crew response for the alert event, identifying a current operational phase of the vehicle, contextualizing, based on the current operational phase, the alert event to assign an alert level to the alert event, and outputting, for display, the alert event.