Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

Abstract: An implanted neurostimulator has a processor which controls stimulation parameter values to create stimulation signals which are applied to a patient's body to maintain relative proportional amplitudes of a set of linked stimulation signals during stimulation in accordance with a stimulation protocol. An external programmer receives user input data and can adjust the stimulation protocol. A set of independently operable electrode contacts are electrically coupled to the neurostimulator and the set of independently operated electrode contacts have at least two subset electrode contacts which are linked together to receive the set of linked stimulation signals. An information transmission system has telemetry circuitry to transmit to the neurostimulator the set of stimulation signal values in accordance with the stimulation protocol.

Abstract: A system to configure a neurostimulation signal to a patient's body has a neurostimulator to create a base stimulation signal which has a series of first pulses. A computer processor within the neurostimulator deconstructs the first series of pulses into a first and second partial pulse series which have respective first and second partial electrical pulses where the first and second partial electrical pulses substantially summate to the base stimulation signal. A programmable signal generator provides a constant amplitude of combined stimulation pulses by applying the first and second partial pulses to a number of contacts of an electrode positionally located to stimulate a target tissue in the patient's body.

Abstract: A method of treating a patient having overactive bladder symptoms by a combination of stimulation of the patient's saphenous nerve and the patient's posterior tibial nerve. The method uses a neurostimulator having a computer processor and a signal generator which generates a first stimulation signal which is used to target the patient's saphenous nerve and a second stimulation signal which is used to target the posterior tibial nerve of the patient in accordance with a treatment protocol. The neurostimulator sends the first and second electrical stimulation signals to respective stimulators which then transmit the respective electrical stimulation signals to the patient's saphenous nerve and the patient's posterior tibial nerve in accordance with the stimulation protocol. The first and second stimulators are positioned in locations on the body of the patient to effectively modulate the patient's saphenous nerve and posterior tibial nerve respectively.

Abstract: One or more processors receive a request for a secure digital asset and execute a validation protocol defined for validating the request. The validation protocol may define conditions for fulfilling the request that include one or more conditions related to information about an identified user requesting the request or information indicative of a routing-aspect of the request. The one or more processors attempt to validate the request based on assessment of the conditions specified in the validation protocol. If validation is unsuccessful, the one or more processors instruct the user to undertake one or more multi-factor authentication actions, which may include choices from a plurality of possible multi-factor authentication options and/or certain required multi-factor authentication options, defined by the protocol. The one or more processors validate and fulfil the request responsive to confirming successful undertaking of the one or more multi-factor authentication actions by the user.

Abstract: A patient management platform (PMP) system is provided for neurostimulation treatment of voiding disorders in clinical care settings. The system has a whiteboard device associated with a patient or a care provider, at least one processor coupled to the whiteboard device, and memory coupled to the at least one processor and storing instructions. When the at least one processor performs the instructions, the whiteboard device outputs a display of a first set of information about the patient which includes at least information related to providing treatment of a voiding disorder including at least the provision of neurostimulation treatment. The processor further calculates at least one condition of the patient related to treatment of the voiding disorder; and based on the calculations related to treatment of the voiding disorder, the whiteboard device performs at least one treatment operation that is provided to the patient for the treatment of the voiding disorder.

Abstract: Systems and methods provide stimulation of peripheral targets such as targets in the lower limbs. Electrode arrays realized in circumferential or longitudinal embodiments have pads with horizontal and/or vertical offsets. Electrode array geometries are customizable and adaptable to individual users and treatment of different disorders. Novel systems of customization include software and hardware implemented solutions. A single device can provide treatment of two or more disorders or unwanted states using selected electrode geometries and stimulation protocols. Systems and methods for assessment of candidate stimulation sites and protocols use subjective or objective measures or both to determine which meet stimulation success criteria. Simulation is provided using transcutaneous, percutaneous, or implantable stimulators. A main advantage is the improved treatment of pelvic floor disorders, and especially overactive bladder (OAB).

Abstract: One or more processors receive a request for a secure digital asset and execute a validation protocol defined for validating the request. The validation protocol may define conditions for fulfilling the request that include one or more conditions related to information about an identified user requesting the request or information indicative of a routing-aspect of the request. The one or more processors attempt to validate the request based on assessment of the conditions specified in the validation protocol. If validation is unsuccessful, the one or more processors instruct the user to undertake one or more multi-factor authentication actions, which may include choices from a plurality of possible multi-factor authentication options and/or certain required multi-factor authentication options, defined by the protocol. The one or more processors validate and fulfil the request responsive to confirming successful undertaking of the one or more multi-factor authentication actions by the user.

Abstract: A neurostimulation treatment method for decreasing an unwanted symptom of a person's headache. A set of transcutaneous electrodes are positioned to be in contact to the skin surface of the person's body. A computer processor controls an electrical signal generator based upon a stimulation protocol designed to treat the unwanted symptom of the headache and generates a modulated stimulation signal. The signal generator is controlled to generate a modulated stimulation signal as a high frequency carrier signal having a roving high in a first high frequency range between 80 Hz and 200 Hz. The high frequency is adjusted to rove between a first roving frequence and a second roving frequency according to the stimulation protocol to transmit the modulated stimulation signal to the transcutaneous electrodes which transmit the modulated stimulation signal for treatment of the person.

Abstract: Systems and methods for providing curated neurostimulation where users are enabled to provide improved therapy in a home environment. Stimulation protocols can be assessed to provide improved targeted stimulation of a nerve and less unwanted side effects. Sets of stimulation montages and associated weights are defined and are selected or adjusted in pre-defined using pre-defined operations that simplify adjustment of characteristics of the stimulation field such as the geometry and location of the provided stimulation. Stimulation matrix pads are arranged and activated to provide advantages. Strategies for adjusting the intensity of the stimulation field incorporate weighting values in non-primary channels and are disclosed. Curated neurostimulation can provide defined schedules for events and activities related to the therapy such as providing schedules for stimulation treatment, surveying a user, providing education and remote user support.

Abstract: A method to guide a targeted neurostimulation to the brain of a patient. Neuroimaging data is sensed from the brain of the patient. A processor is used to evaluate the neuroimaging data in order to calculate result data for a modeled functional measure of a particular brain network which defines a first brain region and a second brain region. A target location is determined in the first brain region based upon the result data and a functional connection measure between first and second brain region. A transcranial magnetic stimulator is adjusted to provide a magnetic stimulation signal for stimulation of the target location.

Abstract: Systems and methods for providing curated neurostimulation are disclosed such that users are enabled to provide improved therapy in a home environment. Stimulation protocols can be assessed to provide improved targeted stimulation of a nerve and less unwanted side effects. Sets of stimulation montages and associated weights are defined and are selected or adjusted in pre-defined using pre-defined operations that simplify adjustment of characteristics of the stimulation field such as the geometry and location of the provided stimulation. Stimulation matrix pads are arranged and activated to provide advantages. Strategies for adjusting the intensity of the stimulation field incorporate weighting values in non-primary channels and are disclosed. Curated neurostimulation can also include providing defined schedules for events and activities related to the therapy such as providing schedules for stimulation treatment, surveying a user, providing education and remote user support.

Abstract: An illustrative fraud deterrent method includes presenting an identity verification option for a first website displayed in a web-browser, the option including offering a login to a third-party website, unrelated to the first website. The method further includes receiving login information for a first user account on the third-party website and verifying the login information through a verification service associated with the third-party website, to verify that the login information is valid for the first user account, identified by the login information. The method additionally includes verifying an identity at the first website, responsive to the verification.

Abstract: One or more processors receive a request for a secure digital asset and execute a validation protocol defined for validating the request. The validation protocol may define conditions for fulfilling the request that include one or more conditions related to information about an identified user requesting the request or information indicative of a routing-aspect of the request. The one or more processors attempt to validate the request based on assessment of the conditions specified in the validation protocol. If validation is unsuccessful, the one or more processors instruct the user to undertake one or more multi-factor authentication actions, which may include choices from a plurality of possible multi-factor authentication options and/or certain required multi-factor authentication options, defined by the protocol. The one or more processors validate and fulfil the request responsive to confirming successful undertaking of the one or more multi-factor authentication actions by the user.

Abstract: A neuromodulation system includes a conductive element, a magnetic field generator, a power module and a computer processor. The conductive element located internal a patient's body. At least a portion of the conductive element is positioned adjacent to a target tissue. The magnetic field generator is positioned external to the patient's body. The magnetic field generator generates a time varying magnetic field for inducing stimulation of the target tissue in combination with the conductive element to produce stimulation that is larger than that which would occur in the absence of the conductive element. The power module supplies power to the magnetic field generator. The computer processor controls the time varying magnetic field provided by the magnetic field generator according to at least one set of stimulation parameters.

Abstract: Stimulation treatment of medical disorders use stimulation parameters that provide stimulation of a target site directly or create partial stimulation signals that combine into vector signals that stimulate a target site. Stimulation signals have characteristics such as frequency, timing, temporal content that is adjusted for the person being treated. Signals are designed with advantageous characteristics to influence target tissue in an intended manner and avoid producing unwanted side-effects. Stimulation signals are designed to match or avoid internal/endogenous activity (e.g., brain patterns and rhythms) of a patient. Methods for choosing, creating and partial signals are disclosed. Tissue modulation may be accomplished with electrical and/or magnetic stimulation, such as repetitive transcranial magnetic stimulation.

Abstract: Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Improvements for the treatment of pain are disclosed.

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

Abstract: An illustrative fraud deterrent method includes presenting an identity verification option for a first website displayed in a web-browser, the option including offering a login to a third-party website, unrelated to the first website. The method further includes receiving login information for a first user account on the third-party website and verifying the login information through a verification service associated with the third-party website, to verify that the login information is valid for the first user account, identified by the login information. The method additionally includes verifying an identity at the first website, responsive to the verification.

Abstract: One or more processors receive a request for a secure digital asset and execute a validation protocol defined for validating the request. The validation protocol may define conditions for fulfilling the request that include one or more conditions related to information about an identified user requesting the request or information indicative of a routing-aspect of the request. The one or more processors attempt to validate the request based on assessment of the conditions specified in the validation protocol. If validation is unsuccessful, the one or more processors instruct the user to undertake one or more multi-factor authentication actions, which may include choices from a plurality of possible multi-factor authentication options and/or certain required multi-factor authentication options, defined by the protocol. The one or more processors validate and fulfil the request responsive to confirming successful undertaking of the one or more multi-factor authentication actions by the user.