Abstract: Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content. Improvements for the treatment of pain are disclosed.

Abstract: A neurostimulation system is disclosed for providing treatment to a patient during a therapy session. The neurostimulation system includes a neurostimulator for transmitting magnetic or electrical signals based upon a treatment program. A programmer is connected to the neurostimulator to set a treatment session parameter value to calculate a therapy compliance value. A compliance module is connected to the neurostimulator and the programmer to calculate and store a therapy compliance value. A control module is connected to the compliance module, the programmer and the neurostimulator and determines whether the therapy compliance value is within a range of the treatment program. The neurostimulator transmits electrical or magnetic signals to the patient in a treatment session only if the therapy compliance value meets a compliance criteria.

Abstract: Methods and systems for improving nerve stimulation are disclosed which relate to shaping characteristics of the stimulation field such as by using different geometries and locations of stimulation. In embodiments, systems and methods are provided to improve selective modulation of specific targeted neural substrate, while minimizing the activation of adjacent non-targeted nervous tissue.

Abstract: A drug delivery system provides for controlled mixing of drugs, using at least one mixing chamber. Flow controllers guide drugs into single or multiple catheters, enabling a single lumen catheter to dispense multiple drugs, diluting a concentrated drug to provide varying drug concentration. A buffer fluid can deliver precise drug amounts or can separate drugs within a catheter. A patient's bodily fluid can serve as a diluent or buffer fluid. A drug testing/filler apparatus may be used to facilitate filling of multiple reservoirs. Bolus or continuous delivery of drug to selected distal locations can occur at independent rates. New catheter systems, hub assemblies, and uses therefore are also described. New methods for promotion of healthy pregnancy and treatment of a developing fetus are disclosed.

Abstract: Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content. Improvements for the treatment of pain are disclosed.

Abstract: Nerve stimulation systems and methods are disclosed for providing modulation of nerve targets in the lower limbs typically at or below the knee. For example, transcutaneous electrical nerve stimulation (TENS), percutaneous nerve stimulation, and implantable stimulation systems and methods are disclosed for providing stimulation to the saphenous nerve (SAFN). Additionally, systems and methods are provided for co-stimulating the posterior tibial nerve (PTN) and SAFN in combination with unique stimulation, and with control and display of OAB therapy protocols for multiple sites. Systems and methods of treatment can provide for management of usage and compliance monitoring, obtain and operating upon patient input responses to queries and management of payments and permissions related to provision of therapies for various disorders. Monitoring of usage and compliance can be managed both locally and remotely from a user. Stimulation provided in combination with a passive implantable component is also disclosed.

Abstract: Stimulation treatment of medical disorders use stimulation parameters that provide stimulation of a target site directly or create partial stimulation signals that combine into vector signals that stimulate a target site. Stimulation signals have characteristics such as frequency, timing, temporal content that is adjusted for the person being treated. Signals are designed with advantageous characteristics to influence target tissue in an intended manner and avoid producing unwanted side-effects. Stimulation signals are designed to match or avoid internal/endogenous activity (e.g., brain patterns and rhythms) of a patient. Methods for choosing, creating and partial signals are disclosed. Tissue modulation may be accomplished with electrical and/or magnetic stimulation, such as repetitive transcranial magnetic stimulation.

Abstract: Methods and systems for improving nerve stimulation are disclosed and are termed enhanced transcutaneous electrical stimulation (eTENS). One embodiment can be used for enhancing the excitation properties of neural tissue. In one embodiment, systems and methods are provided to enable the selective modulation of specific (targeted) neural substrate, while minimizing the activation of adjacent (non-targeted) nervous tissue, or differentially providing different modulation signals to tissue targeted by different implants. In one embodiment, the system consists of an implant that is used to modify the extracellular potential (i.e. activating function) generated by an independent electrical stimulus generator. Certain aspects of this technology can be applied to any part of the central and peripheral nervous systems. Particular embodiments of this technology provide for therapy related to urological disorders.

Abstract: Stimulation treatment of medical disorders use stimulation parameters that provide stimulation of a target site directly or create partial stimulation signals that combine into vector signals that stimulate a target site. Stimulation signals have characteristics such as frequency, timing, temporal content that is adjusted for the person being treated. Signals are designed with advantageous characteristics to influence target tissue in an intended manner and avoid producing unwanted side-effects. Stimulation signals are designed to match or avoid internal/endogenous activity (e.g., brain patterns and rhythms) of a patient. Methods for choosing, creating and partial signals are disclosed. Tissue modulation may be accomplished with electrical and/or magnetic stimulation, such as repetitive transcranial magnetic stimulation.

Abstract: This application includes systems and techniques relating to wirelessly rechargeable medical apparatus, such as a wirelessly powered medical device including: a wireless energy harvesting module configured to receive at least one type of wireless power; a power management module configured to manage and monitor power harvested by the wireless energy harvesting module; a sensing or stimulation module configured to provide sensing data or a treatment operation; and a control module configured to communicate with the power management module and with the sensing or stimulation module; wherein the power management module and the control module are configured to communicate with each other to modify an interrelation of operations of the wireless energy harvesting module and the sensing or stimulation module, including to compensate for influences of wireless power harvesting on operation of the sensing module or on the treatment operation provided by the stimulation module.

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

Abstract: A neuromodulation system includes a conductive element, a magnetic field generator, a power module and a computer processor. The conductive element located internal a patient's body. At least a portion of the conductive element is positioned adjacent to a target tissue. The magnetic field generator is positioned external to the patient's body. The magnetic field generator generates a time varying magnetic field for inducing stimulation of the target tissue in combination with the conductive element to produce stimulation that is larger than that which would occur in the absence of the conductive element. The power module supplies power to the magnetic field generator. The computer processor controls the time varying magnetic field provided by the magnetic field generator according to at least one set of stimulation parameters.

Abstract: A transmitter, according to some implementations, includes: at least two antennas configured to transmit at least two radio frequency power signals; a power transmission module connected to the at least two antennas, the power transmission module configured to generate the at least two radio frequency power signals; and a power transmitter control module connected to the power transmission module, the power transmitter control module configured to control a first phase and a first amplitude of a first of the at least two radio frequency power signals and a second phase and a second amplitude of a second of the at least two radio frequency power signals to concurrently provide respective summations of the first and second radio frequency power signals at a first wireless power receiver of a first electronic device and at a second wireless power receiver of a second electronic device via constructive interference.

Abstract: Stimulation treatments for medical disorders comprise providing stimulation parameters that create partial stimulation signals which combine into vector signals. The individual partial signals may have frequency or temporal content that is unique rather than all being identical. Vector signals may thus be designed with certain advantageous characteristics such as to influence target tissue in an intended manner while partial signals may be designed with other advantageous characteristics such as to avoid producing side effects in adjacent tissue. Roving of stimulation parameters can be designed to influence partial signals, vectors signals, or both. Partial and vector signals may be designed to match or avoid internal/endogenous activity patterns and rhythms of a patient. Methods for choosing, creating and using partial signals are disclosed. Tissue modulation may be accomplished with electrical and/or magnetic stimulation.

Abstract: Improved systems are disclosed for providing advantages during stimulation of peripheral nerves using transcutaneous, percutaneous, and implantable stimulators. Percutaneous stimulation is improved by accessories that guide the angel and depth of injection to allow for easy and controlled needle injection. Transcutaneous stimulation is improved using pressure to improve nerve recruitment. Systems and methods are disclosed for providing nerve stimulation of a patient to treat medical disorders and conditions within a single user or multiple user environments such as assisted living centers.

Abstract: Methods for providing therapy related to urological disorders. Particular embodiments of this technology relate to stimulation of lumbar spinal targets either alone or in combination with a sacral target or targets. In embodiments spinal roots are stimulated by partially or fully implanted stimulators to treat symptoms by producing bladder inhibition relative to that which occurs prior to stimulation. Embodiments also disclose improving nerve stimulation, including lumbar nerve root stimulation, using methods termed enhanced transcutaneous electrical stimulation (eTENS) since these enhance the inhibition or excitation of neural tissue.

Abstract: Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content. Improvements for the treatment of pain are disclosed.

Abstract: Nerve stimulation systems and methods are disclosed for providing improved compliance of a patient to a therapy regimen. Patient compliance is assessed and notification or treatment events can be scheduled, rescheduled or otherwise adjusted based upon patient compliance or non-compliance according to compliance rules and parameters of a treatment compliance module. Both compliance and non-compliance may lead to adjustment of the treatment regimen, scheduled treatment events, and notifications. Gamification of the treatment regimen allows users to obtain points that may be used to receive virtual awards, status awards, or monetary compensation of various forms. Monitoring of usage and compliance can be managed both locally and remotely from the user. Stimulation treatment, compliance monitoring, and gamification is disclosed for treatments using external or implanted stimulators, or the combination.

Abstract: Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content.

Abstract: A resonator connector for a wireless power transfer system includes: one or more conducting materials to carry electricity between two or more electromagnetic resonators; a first plug coupled with the one or more conducting materials; a second plug coupled with the one or more conducting materials; and an impedance module coupled with the one or more conducting materials, the impedance module including an impedance matching network; wherein the impedance module is configurable to adjust electrical properties of the one or more conducting materials, using the impedance matching network, when the resonator connector electrically couples together the two or more electromagnetic resonators of the wireless power transfer system including at least three electromagnetic resonators, so as to improve power transfer efficiency among the at least three electromagnetic resonators of the wireless power transfer system, the at least three electromagnetic resonators including the two or more electromagnetic resonators.