Abstract: In an embodiment, a voltage reference circuit is disclosed that includes a first transistor circuit that is configured to receive an external supply voltage as an input and to output a first voltage and a chopper circuit that is configured to receive a second voltage as an input and to output a voltage reference. The chopper circuit has a breakage threshold. The voltage reference circuit further includes a second transistor circuit that is configured to receive the first voltage as an input and to output the second voltage at a value that is less than or equal to the breakage threshold of the chopper circuit.

Abstract: A computer-implemented method for generating a cover set of biological sequences to detect a group of biological members. The method includes one or more computer processors receiving a request to generate a cover set of k-mers used to detect a first group of biological members that are related via a taxonomic lineage. The method further includes obtaining a plurality of biological sequence data corresponding to biological members of the first group. The method further includes determining a set of k-mers respectively associated with a biological member included within the first group of biological members. The method further includes determining the cover set of k-mers utilized to detect the biological members of the first group by selecting a subset of k-mers from a superset of k-mers associated with the first group of biological members based on preventing false-positive detections of biological members different from the first group of biological members.

Abstract: A computer-implemented method includes receiving genomic data associated with a plurality of genomes and identifying k-mer sets within the genomic data. The method includes constructing a k-mer subset tree according to the following process: performing iterative pairwise comparisons on the k-mer sets, wherein the iterative pairwise comparisons identify fragments with the most shared k-mers, merging the identified fragments into non-leaf nodes of the k-mer subset tree, and placing each remaining k-mer into a leaf node of the k-mer subset tree. The method includes storing the k-mer subset tree. A computer program product for data compression includes a computer readable storage medium having program instructions embodied therewith. The program instructions are executable by a computer to cause the compute to perform the foregoing method. A system includes a processor and logic. The logic is configured to perform the foregoing method.

Abstract: The invention notably relates to a computer-implemented method for designing a 3D modeled object by interaction of a user with a feature-based CAD system, the 3D modeled object representing a mechanical structure. The method comprises creating structural member features, each structural member feature representing a respective structural member of the mechanical structure, and displaying to the user a graphical representation of the mechanical structure based on the structural member features. The method further comprises creating corner features, each corner feature representing a respective corner of the mechanical structure, the creation of the corner features being performed automatically by the system, the corner features being editable by the user. This provides improved ergonomics for structural design.

Abstract: Provided are systems and methods for analyzing actions performed by users in using a cloud service, and adjusting the configuration of a security management and control system based on the analysis. In various examples, the analysis can include generating a weighted directed graph that reflects a user's use of the cloud service, and/or reflects the tenant's overall use of the cloud service. When the security monitoring and control system generates security alerts, the actions that resulted in the alerts can be compared to the graph to determine whether the actions are in accordance with prior behavior of the users. When the actions do correspond to the graph, the system can recommend that the security control or security policy that triggered the alert be modified. In various examples, the graphs can also be used to determine whether any user's actions are anomalous as compared to earlier behavior.

Abstract: Provided are systems and methods for analyzing actions performed by users in using a cloud service, and adjusting the configuration of a security management and control system based on the analysis. In various examples, the analysis can include generating a weighted directed graph that reflects a user's use of the cloud service, and/or reflects the tenant's overall use of the cloud service. When the security monitoring and control system generates security alerts, the actions that resulted in the alerts can be compared to the graph to determine whether the actions are in accordance with prior behavior of the users. When the actions do correspond to the graph, the system can recommend that the security control or security policy that triggered the alert be modified. In various examples, the graphs can also be used to determine whether any user's actions are anomalous as compared to earlier behavior.

Abstract: Described herein are methods for treating transthyretin (TTR) amyloidosis in a subject.

Abstract: Described herein are methods for treating transthyretin (TTR) amyloidosis in a subject. The methods include specific dosing regimens that have great efficacy in treating the subjects and that are well tolerated in subjects.

Abstract: A computer-implemented method includes receiving genomic data associated with a plurality of genomes and identifying k-mer sets within the genomic data. The method includes constructing a k-mer subset tree according to the following process: performing iterative pairwise comparisons on the k-mer sets, wherein the iterative pairwise comparisons identify fragments with the most shared k-mers, merging the identified fragments into non-leaf nodes of the k-mer subset tree, and placing each remaining k-mer into a leaf node of the k-mer subset tree. The method includes storing the k-mer subset tree. A computer program product for data compression includes a computer readable storage medium having program instructions embodied therewith. The program instructions are executable by a computer to cause the compute to perform the foregoing method. A system includes a processor and logic. The logic is configured to perform the foregoing method.

Abstract: Provided are systems and methods for analyzing actions performed by users in using a cloud service, and adjusting the configuration of a security management and control system based on the analysis. In various examples, the analysis can include generating a weighted directed graph that reflects a user's use of the cloud service, and/or reflects the tenant's overall use of the cloud service. When the security monitoring and control system generates security alerts, the actions that resulted in the alerts can be compared to the graph to determine whether the actions are in accordance with prior behavior of the users. When the actions do correspond to the graph, the system can recommend that the security control or security policy that triggered the alert be modified. In various examples, the graphs can also be used to determine whether any user's actions are anomalous as compared to earlier behavior.

Abstract: The invention notably relates to a computer-implemented method for designing a 3D modeled object by interaction of a user with a feature-based CAD system, the 3D modeled object representing a mechanical structure. The method comprises creating structural member features, each structural member feature representing a respective structural member of the mechanical structure, and displaying to the user a graphical representation of the mechanical structure based on the structural member features. The method further comprises creating corner features, each corner feature representing a respective corner of the mechanical structure, the creation of the corner features being performed automatically by the system, the corner features being editable by the user. This provides improved ergonomics for structural design.

Abstract: A computer-implemented method and system creates a multi-element feature in a three-dimensional (3D) computer-aided design (CAD) model. A first element and a second element are selected to include in the multi-element feature. A single sketch is created comprised of sketch entities, a subset of which defines the first element and another subset of which defines the second element. A connection entity is included in the single sketch. The connection entity joins the first and the second elements. A modeling operation applied to the single sketch creates the multi-element feature.

Abstract: A computer-implemented method and system creates a multi-element feature in a three-dimensional (3D) computer-aided design (CAD) model. A first element and a second element are selected to include in the multi-element feature. A single sketch is created comprised of sketch entities, a subset of which defines the first element and another subset of which defines the second element. A connection entity is included in the single sketch. The connection entity joins the first and the second elements. A modeling operation applied to the single sketch creates the multi-element feature.

Abstract: Described herein are methods for treating transthyretin (TTR) amyloidosis in a subject. The methods include specific dosing regimens that have great efficacy in treating the subjects and that are well tolerated in subjects.

Abstract: A system and methods of diagnosing and monitoring neurological disorders in a patient utilizing an artificial intelligence based system. The system may comprise a plurality of sensors, a collection of trained machine learning based diagnostic and monitoring tools, and an output device. The plurality of sensors may collect data relevant to neurological disorders. The trained diagnostic tool will learn to use the sensor data to assign risk assessments for various neurological disorders. The trained monitoring tool will track the development of a disorder over time and may be used to recommend or modify the administration of relevant treatments. The goal of the system is to render an accurate evaluation of the presence and severity of neurological disorders in a patient without requiring input from an expertly trained neurologist.

Abstract: A system, method, and computer program product are provided for automatic discard of corrupt memory segments. In use, one or more memory blocks are allocated to specific business related information. Additionally, the one or more memory blocks allocated to the specific business related information are assigned to one or more first memory regions, the one or more first memory regions being a portion of a memory that includes a plurality of memory regions in addition to the one or more first memory regions, the plurality of memory regions including a plurality of other business related information. Further, it is identified that the specific business related information is corrupt. Moreover, the specific business related information is discarded from the memory and a master memory, such that the plurality of other business related information is not discarded.

Abstract: A computer-implemented method and system creates a multi-element feature in a three-dimensional (3D) computer-aided design (CAD) model. A first element and a second element are selected to include in the multi-element feature. A single sketch is created comprised of sketch entities, a subset of which defines the first element and another subset of which defines the second element. A connection entity is included in the single sketch. The connection entity joins the first and the second elements. A modeling operation applied to the single sketch creates the multi-element feature.

Abstract: A content delivery network (CDN) edge server is provisioned to provide last mile acceleration of content to requesting end users. The CDN edge server fetches, compresses and caches content obtained from a content provider origin server, and serves that content in compressed form in response to receipt of an end user request for that content. It also provides “on-the-fly” compression of otherwise uncompressed content as such content is retrieved from cache and is delivered in response to receipt of an end user request for such content. A preferred compression routine is gzip, as most end user browsers support the capability to decompress files that are received in this format. The compression functionality preferably is enabled on the edge server using customer-specific metadata tags.

Abstract: A routing mechanism, service or system operable in a distributed networking environment. One preferred environment is a content delivery network (CDN) wherein the present invention provides improved connectivity back to an origin server, especially for HTTP traffic. In a CDN, edge servers are typically organized into regions, with each region comprising a set of content servers that preferably operate in a peer-to-peer manner and share data across a common backbone such as a local area network (LAN). The inventive routing technique enables an edge server operating within a given CDN region to retrieve content (cacheable, non-cacheable and the like) from an origin server more efficiently by selectively routing through the CDN's own nodes, thereby avoiding network congestion and hot spots.